Abstract: "This study included 27,670 participants (mean baseline age 58.1 years, SD 7.6; 61% female). During a median of 25 years of follow-up, 3,208 incident dementia cases were recorded. Consumption of ≥50 g/d of high-fat cheese (>20% fat) was associated with a reduced risk of all-cause dementia (HR 0.87; 95% CI, 0.78–0.97) and VaD (HR 0.71, 95% CI 0.52–0.96) compared with lower intake (<15 g/d). An inverse association between high-fat cheese and AD was found among APOE ε4 noncarriers (HR 0.87, 95% CI 0.76–0.99, p-interaction = 0.014). Compared with no consumption, individuals consuming ≥20 g/d of high-fat cream (>30% fat) had a 16% lower risk of all-cause dementia (HR 0.84, 95% CI 0.72–0.98). High-fat cream consumption was inversely associated with the risk of AD and VaD. Consumption of low-fat cheese, low-fat cream, milk (high-fat and low-fat), fermented milk (high-fat and low-fat), and butter showed no association with all-cause dementia."
apothegm•1mo ago
A hundred bucks says the correlation goes away if you control for factors that are likely a shared root cause for dementia and avoiding high fat dairy. Such as trying to control pre-existing obesity or high cholesterol.
mfworks•1mo ago
They did in fact control for these factors.
> Body mass index (BMI) was calculated from measured weight and height and categorized into 4 groups (<18.5, 18.5–24.9, 25–29.9, and ≥30 kg/m2). Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg, or the use of antihypertensive medication. Diabetes was identified through self-reported diagnosis, medication usage, and registry records. The intake of lipid-lowering drugs was self-reported. Baseline blood lipoproteins were only available in 4,549 participants and, therefore, not included as covariates. The APOE genotype was determined based on 2 single-nucleotide variants, rs429358 and rs7412, which define the ε2, ε3, and ε4 alleles. Participants carrying at least 1 ε4 allele were classified as APOE ε4 carriers.
brokensegue•1mo ago
Depression correlates with dementia. As do many drugs to treat various psychiatric conditions
naveen99•1mo ago
What’s your favorite school of mental gymnastics?
adrian_b•1mo ago
The study clearly demonstrates that what one eats can greatly influence the risk of dementia, like also for many other old-age diseases, but its scope was far too limited to allow the identification of the food components that determine the risk of dementia.
Others have said that perhaps not dairy fat per se was beneficial, but some fat-soluble vitamins and essential nutrients.
It is also possible that those with higher dementia risk did not eat enough fatty essential nutrients, but this deficiency could have equally been covered by other healthier sources of fat, e.g. by a suitable combination of vegetable oils, but the study has not investigated at all this possibility.
Anecdotally, due to my personal experience, I believe that dairy fat is harmful for cardiovascular health.
About 5 years ago, I became scared when a medical checkup had concluded that I have symptoms of incipient atherosclerosis.
I examined what I was eating, to find what I could improve. I was already eating mostly healthy food and in an amount small enough to maintain constant an optimum weight. A couple of decades earlier, I had been obese for many years, but then, after some failed attempts, I had eventually learned to control my weight and I had reduced my weight to 2/3 of the previous weight, and then I have maintained that weight until today.
The only wrong thing that I could identify in my diet was that I was eating very large amounts of dairy, thus a high amount of saturated fat. I stopped immediately eating any dairy. Since then until now, more than 90% of my daily intake of fat is provided by a mixture of oils that I use in cooking my food, which has an optimum profile of fatty acids, according to the current knowledge, i.e. the most abundant fatty acid is oleic acid (provided by olive oil, avocado oil or high-oleic sunflower oil), there is an adequate amount of linoleic acid and vitamin E (provided by cold-pressed sunflower oil) and an adequate amount of omega-3 DHA & EPA (provided by cod liver oil), to which a drop of an oil with vitamins D3 & K2 is added.
After a year since the switching from dairy consumption to consuming a good mixture of oils, not only the symptoms of incipient atherosclerosis had completely disappeared, but also other signs of bad peripheral circulation that had affected me for many years, e.g. cold feet, had also completely disappeared.
Therefore, based on the success of this change in my diet, I believe that my initial assumption, that the fat from dairy was harmful for me, has been correct. Today, the only products derived from milk that I continue to eat are whey protein concentrate or, more rarely, milk protein concentrate, which have negligible fat.
Also in the medical literature, there have been a great number of studies where replacing dairy with better sources of fat has lead to improvements in cardiovascular diseases or in some other diseases, e.g. multiple sclerosis.
In conclusion, I believe that this study is correct in the sense that an adequate intake of fatty nutrients is important for the health of the brain and of the nervous system, but it has not demonstrated at all that dairy fat is the correct solution, because dairy fat has not been compared with other sources of fat.
bikenaga•1mo ago
Abstract: "This study included 27,670 participants (mean baseline age 58.1 years, SD 7.6; 61% female). During a median of 25 years of follow-up, 3,208 incident dementia cases were recorded. Consumption of ≥50 g/d of high-fat cheese (>20% fat) was associated with a reduced risk of all-cause dementia (HR 0.87; 95% CI, 0.78–0.97) and VaD (HR 0.71, 95% CI 0.52–0.96) compared with lower intake (<15 g/d). An inverse association between high-fat cheese and AD was found among APOE ε4 noncarriers (HR 0.87, 95% CI 0.76–0.99, p-interaction = 0.014). Compared with no consumption, individuals consuming ≥20 g/d of high-fat cream (>30% fat) had a 16% lower risk of all-cause dementia (HR 0.84, 95% CI 0.72–0.98). High-fat cream consumption was inversely associated with the risk of AD and VaD. Consumption of low-fat cheese, low-fat cream, milk (high-fat and low-fat), fermented milk (high-fat and low-fat), and butter showed no association with all-cause dementia."
apothegm•1mo ago
mfworks•1mo ago
> Body mass index (BMI) was calculated from measured weight and height and categorized into 4 groups (<18.5, 18.5–24.9, 25–29.9, and ≥30 kg/m2). Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg, or the use of antihypertensive medication. Diabetes was identified through self-reported diagnosis, medication usage, and registry records. The intake of lipid-lowering drugs was self-reported. Baseline blood lipoproteins were only available in 4,549 participants and, therefore, not included as covariates. The APOE genotype was determined based on 2 single-nucleotide variants, rs429358 and rs7412, which define the ε2, ε3, and ε4 alleles. Participants carrying at least 1 ε4 allele were classified as APOE ε4 carriers.
brokensegue•1mo ago
naveen99•1mo ago
adrian_b•1mo ago
Others have said that perhaps not dairy fat per se was beneficial, but some fat-soluble vitamins and essential nutrients.
It is also possible that those with higher dementia risk did not eat enough fatty essential nutrients, but this deficiency could have equally been covered by other healthier sources of fat, e.g. by a suitable combination of vegetable oils, but the study has not investigated at all this possibility.
Anecdotally, due to my personal experience, I believe that dairy fat is harmful for cardiovascular health.
About 5 years ago, I became scared when a medical checkup had concluded that I have symptoms of incipient atherosclerosis.
I examined what I was eating, to find what I could improve. I was already eating mostly healthy food and in an amount small enough to maintain constant an optimum weight. A couple of decades earlier, I had been obese for many years, but then, after some failed attempts, I had eventually learned to control my weight and I had reduced my weight to 2/3 of the previous weight, and then I have maintained that weight until today.
The only wrong thing that I could identify in my diet was that I was eating very large amounts of dairy, thus a high amount of saturated fat. I stopped immediately eating any dairy. Since then until now, more than 90% of my daily intake of fat is provided by a mixture of oils that I use in cooking my food, which has an optimum profile of fatty acids, according to the current knowledge, i.e. the most abundant fatty acid is oleic acid (provided by olive oil, avocado oil or high-oleic sunflower oil), there is an adequate amount of linoleic acid and vitamin E (provided by cold-pressed sunflower oil) and an adequate amount of omega-3 DHA & EPA (provided by cod liver oil), to which a drop of an oil with vitamins D3 & K2 is added.
After a year since the switching from dairy consumption to consuming a good mixture of oils, not only the symptoms of incipient atherosclerosis had completely disappeared, but also other signs of bad peripheral circulation that had affected me for many years, e.g. cold feet, had also completely disappeared.
Therefore, based on the success of this change in my diet, I believe that my initial assumption, that the fat from dairy was harmful for me, has been correct. Today, the only products derived from milk that I continue to eat are whey protein concentrate or, more rarely, milk protein concentrate, which have negligible fat.
Also in the medical literature, there have been a great number of studies where replacing dairy with better sources of fat has lead to improvements in cardiovascular diseases or in some other diseases, e.g. multiple sclerosis.
In conclusion, I believe that this study is correct in the sense that an adequate intake of fatty nutrients is important for the health of the brain and of the nervous system, but it has not demonstrated at all that dairy fat is the correct solution, because dairy fat has not been compared with other sources of fat.