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Achieving Lasting Remission for HIV

https://knowablemagazine.org/content/article/health-disease/2025/lasting-remission-hiv-with-broadly-neutralizing-antibodies
4•PaulHoule•2h ago

Show HN: I created a tool to generate handwritten signatures

https://signcraft.pro/
1•nedoto•1m ago•0 comments

Roots of milk drinking revealed by South Asian genomes

https://www.science.org/content/article/roots-milk-drinking-revealed-south-asian-genomes
1•bikenaga•1m ago•0 comments

What you eat could decide the planet's future

https://www.sciencedaily.com/releases/2025/12/251224032356.htm
1•rhollos•2m ago•0 comments

Disprove or agree with my take on the future (comment or post)

https://twitter.com/jimsbr/status/2004236990716186856
1•usernameisjim•3m ago•1 comments

The Owl, the Scientific Method, and Claude Code

https://vsevolod.net/claude-debug/
1•murkt•4m ago•0 comments

Christmas – But I Wanted to Program

https://number-garden-alive.netlify.app/?9333037093851
1•cpuXguy•8m ago•1 comments

Sierra Christmas Card 1986: A Computer Christmas

https://archive.org/details/sierra-christmas-card-1986
1•jdkee•9m ago•0 comments

Building your own RAM is as 'easy' as sourcing memory modules and soldering them

https://www.tomshardware.com/pc-components/ddr5/russian-enthusiasts-are-building-their-own-ddr5-r...
1•thisislife2•10m ago•0 comments

Lessons from 120 DevTools Interviews

https://scalingdevtools.com/newsletter/18085111
1•mooreds•10m ago•0 comments

Select2 – The jQuery replacement for select boxes

https://select2.org/
1•thunderbong•13m ago•0 comments

RustToolsGDB

https://codeberg.org/laladrik/RustToolsGDB
1•laladrik•16m ago•1 comments

Show HN: nunchux – A handy tmux launcher buddy thing

https://github.com/datamadsen/nunchux
1•tmadsen_•18m ago•0 comments

The first web browser was released on this day in 1990

https://en.wikipedia.org/wiki/WorldWideWeb
1•firefax•20m ago•0 comments

The vibe and the verifier: breaking through scientific barriers with AI

https://renormalize.substack.com/p/the-vibe-and-the-verifier-breaking
2•getnormality•21m ago•0 comments

Facebook Museum-Bringing the End Closer Together

https://networkcultures.org/blog/2025/12/24/facebook-museum/
1•glovink•22m ago•0 comments

Show HN: Gift for Kids – Live Santa AI Video Call

https://callsantatonight.com/christmas-gift-for-kids-santa-ai-video-call
2•s-stude•26m ago•0 comments

Donald Knuth's 2025 Christmas lecture: the Knight's Tours

https://thenewstack.io/donald-knuths-2025-christmas-lecture-the-knights-tours/
4•MilnerRoute•28m ago•0 comments

The Mammoth Pirates – In Russia's Arctic north, a new kind of gold rush

https://www.rferl.org/a/the-mammoth-pirates/27939865.html
2•ece20•29m ago•0 comments

DIY E-Reader Folds Open Like a Book

https://hackaday.com/2025/12/24/diy-e-reader-folds-open-like-a-book/
1•elashri•31m ago•0 comments

Free Speech in Tucson

https://yousaytoday.com/story/3ab31ff0-d955-408a-851d-ac77a9d7c23d
2•mvcalder•32m ago•2 comments

From shoreline to skyscraper: Seashells offer a path to low-carbon concrete

https://techxplore.com/news/2025-12-shoreline-skyscraper-seashells-path-carbon.html
1•PaulHoule•33m ago•0 comments

Available domain names for your next project

https://sneakydomains.com/freebies/pn1y89xgpnmvwdd
4•starf1sh•37m ago•0 comments

Why do we hear the same Christmas songs year after year?

https://text.npr.org/nx-s1-5637477
2•mooreds•37m ago•1 comments

Observability dashboard for an arbitrary LLM langgraph

https://github.com/xbt-a4224j/langgraph-observer
1•mooreds•38m ago•0 comments

AI #148: Christmas Break

https://thezvi.substack.com/p/ai-148-christmas-break
1•paulpauper•39m ago•0 comments

All over the rich world, fewer people are hooking up and shacking up

https://www.economist.com/briefing/2025/11/06/all-over-the-rich-world-fewer-people-are-hooking-up...
2•paulpauper•40m ago•0 comments

Show HN: I treated my brain like a buggy server and wrote a patch (Shi-Mo Model)

https://github.com/317317317apple-a11y/shi-mo-protocol/blob/main/README.md
6•ShiMo_Protocol•42m ago•1 comments

Meta Ads Minimum Daily Budget Calculator

https://fiz-fb-calculator.netlify.app/
1•hafizdhanani•42m ago•1 comments

How I Make These ASCII Pictures and Links to Other Tutorials (2000)

https://web.archive.org/web/20000520115049/http://www.ludd.luth.se/~vk/pics/ascii/junkyard/techst...
1•susam•47m ago•0 comments

Agentic Coding Course

https://agenticoding.ai/
1•ofriw•48m ago•0 comments