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RFCs vs. READMEs: The Evolution of Protocols

https://h3manth.com/scribe/rfcs-vs-readmes/
1•init0•4m ago•1 comments

Kanchipuram Saris and Thinking Machines

https://altermag.com/articles/kanchipuram-saris-and-thinking-machines
1•trojanalert•4m ago•0 comments

Chinese chemical supplier causes global baby formula recall

https://www.reuters.com/business/healthcare-pharmaceuticals/nestle-widens-french-infant-formula-r...
1•fkdk•7m ago•0 comments

I've used AI to write 100% of my code for a year as an engineer

https://old.reddit.com/r/ClaudeCode/comments/1qxvobt/ive_used_ai_to_write_100_of_my_code_for_1_ye...
1•ukuina•9m ago•1 comments

Looking for 4 Autistic Co-Founders for AI Startup (Equity-Based)

1•au-ai-aisl•20m ago•1 comments

AI-native capabilities, a new API Catalog, and updated plans and pricing

https://blog.postman.com/new-capabilities-march-2026/
1•thunderbong•20m ago•0 comments

What changed in tech from 2010 to 2020?

https://www.tedsanders.com/what-changed-in-tech-from-2010-to-2020/
2•endorphine•25m ago•0 comments

From Human Ergonomics to Agent Ergonomics

https://wesmckinney.com/blog/agent-ergonomics/
1•Anon84•29m ago•0 comments

Advanced Inertial Reference Sphere

https://en.wikipedia.org/wiki/Advanced_Inertial_Reference_Sphere
1•cyanf•30m ago•0 comments

Toyota Developing a Console-Grade, Open-Source Game Engine with Flutter and Dart

https://www.phoronix.com/news/Fluorite-Toyota-Game-Engine
1•computer23•32m ago•0 comments

Typing for Love or Money: The Hidden Labor Behind Modern Literary Masterpieces

https://publicdomainreview.org/essay/typing-for-love-or-money/
1•prismatic•33m ago•0 comments

Show HN: A longitudinal health record built from fragmented medical data

https://myaether.live
1•takmak007•36m ago•0 comments

CoreWeave's $30B Bet on GPU Market Infrastructure

https://davefriedman.substack.com/p/coreweaves-30-billion-bet-on-gpu
1•gmays•47m ago•0 comments

Creating and Hosting a Static Website on Cloudflare for Free

https://benjaminsmallwood.com/blog/creating-and-hosting-a-static-website-on-cloudflare-for-free/
1•bensmallwood•53m ago•1 comments

"The Stanford scam proves America is becoming a nation of grifters"

https://www.thetimes.com/us/news-today/article/students-stanford-grifters-ivy-league-w2g5z768z
2•cwwc•57m ago•0 comments

Elon Musk on Space GPUs, AI, Optimus, and His Manufacturing Method

https://cheekypint.substack.com/p/elon-musk-on-space-gpus-ai-optimus
2•simonebrunozzi•1h ago•0 comments

X (Twitter) is back with a new X API Pay-Per-Use model

https://developer.x.com/
3•eeko_systems•1h ago•0 comments

Zlob.h 100% POSIX and glibc compatible globbing lib that is faste and better

https://github.com/dmtrKovalenko/zlob
3•neogoose•1h ago•1 comments

Show HN: Deterministic signal triangulation using a fixed .72% variance constant

https://github.com/mabrucker85-prog/Project_Lance_Core
2•mav5431•1h ago•1 comments

Scientists Discover Levitating Time Crystals You Can Hold, Defy Newton’s 3rd Law

https://phys.org/news/2026-02-scientists-levitating-crystals.html
3•sizzle•1h ago•0 comments

When Michelangelo Met Titian

https://www.wsj.com/arts-culture/books/michelangelo-titian-review-the-renaissances-odd-couple-e34...
1•keiferski•1h ago•0 comments

Solving NYT Pips with DLX

https://github.com/DonoG/NYTPips4Processing
1•impossiblecode•1h ago•1 comments

Baldur's Gate to be turned into TV series – without the game's developers

https://www.bbc.com/news/articles/c24g457y534o
3•vunderba•1h ago•0 comments

Interview with 'Just use a VPS' bro (OpenClaw version) [video]

https://www.youtube.com/watch?v=40SnEd1RWUU
2•dangtony98•1h ago•0 comments

EchoJEPA: Latent Predictive Foundation Model for Echocardiography

https://github.com/bowang-lab/EchoJEPA
1•euvin•1h ago•0 comments

Disablling Go Telemetry

https://go.dev/doc/telemetry
1•1vuio0pswjnm7•1h ago•0 comments

Effective Nihilism

https://www.effectivenihilism.org/
1•abetusk•1h ago•1 comments

The UK government didn't want you to see this report on ecosystem collapse

https://www.theguardian.com/commentisfree/2026/jan/27/uk-government-report-ecosystem-collapse-foi...
5•pabs3•1h ago•0 comments

No 10 blocks report on impact of rainforest collapse on food prices

https://www.thetimes.com/uk/environment/article/no-10-blocks-report-on-impact-of-rainforest-colla...
3•pabs3•1h ago•0 comments

Seedance 2.0 Is Coming

https://seedance-2.app/
1•Jenny249•1h ago•0 comments
Open in hackernews

I Genetically Engineered *Myself* to Fix Lactose Intolerance [video]

https://www.youtube.com/watch?v=J3FcbFqSoQY
31•pinkmuffinere•1mo ago

Comments

rzmmm•1mo ago
I remember reading about this. A key piece of information which should perhaps be in the title of the video is that the "fix" is transient.
pinkmuffinere•1mo ago
There's an update video here: https://www.youtube.com/watch?v=aoczYXJeMY4

Apparently the fix lasted ~18 months

amelius•1mo ago
Could the same fix be applied again?
pinkmuffinere•1mo ago
I know almost nothing about bio, hopefully someone more knowledgeable can answer. But I had the same thought -- one treatment for 18 months of relief sounds great! even people that _are_ lactose tolerant often lose tolerance as they age, so it seems like this could have wide appeal. Do it ~30 times and you could be lactose-tolerant your whole life.
amelius•1mo ago
But wait, if you lose tolerance then there must be some other mechanism involved because your genes stay the same as you age.
pinkmuffinere•1mo ago
He covers it in the video -- the cells lining your intestine are replaced as you age. Unless you get the lactose-tolerant gene into your stem cells, the newly-generated intestine lining will have your 'original' genetics, lacking the lactose tolerant gene. That said, it does sound like it's fading gradually for him, not a sudden drop off.
amelius•1mo ago
I was replying to this part of your comment:

"even people that _are_ lactose tolerant often lose tolerance as they age, so it seems like this could have wide appeal."

My point is that people who are lactose tolerant as a child will have the same genes when they are older. So gene editing should have no effect, unless the mechanism is more complicated somehow.

pinkmuffinere•1mo ago
Oh I see, that makes sense. Ya, I'm not sure how it works, maybe it has something to do with changing gene expression as we age? Ie, not the genes themselves changing, but the way that they are used / neglected? And then if that's the case, what would that mean for people that had taken this treatment? Perhaps they would see the age-related drop off, or perhaps it's different for some reason.
user070223•1mo ago
Thought Emporium entire channel is a goldmine

Here's another youtuber journey to fix the lactose intolerance by just eating lactose(powdered milk)("prebiotic") which had strains of a bacteria("probiotic" which feasts on the prebiotic) that breaks down lactose survives in the microbiome https://www.youtube.com/watch?v=h90rEkbx95w