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Methanol biotransformation for production of plastic monomer L-lactate in yeast

https://www.nature.com/articles/s41467-025-65793-x
2•PaulHoule•2h ago

Tell HN: I switched my iPhone to black and white and it's nice

1•apples_oranges•2m ago•0 comments

One Formula That Demystifies 3D Graphics

https://www.youtube.com/watch?v=qjWkNZ0SXfo
1•mthomas•3m ago•0 comments

Snow-capped Mount Etna erupts as skiers glide down slopes

https://www.bbc.com/news/videos/cz7n4px7e41o
1•tosh•4m ago•0 comments

You are probably not at inbox 0 (but should be) [2013]

https://ploum.net/why-you-are-not-at-inbox-0/index.html
2•maartin0•6m ago•1 comments

The hidden way the big, bad wolf protects us

https://www.washingtonpost.com/climate-environment/interactive/2025/gray-wolfs-safer-roads-delist...
2•pseudolus•6m ago•1 comments

How we achieved 30% Faster Queries by overcoming ClickHouse's native JSON limits

https://newsletter.signoz.io/p/overcoming-clickhouses-json-constraints
1•pranay01•7m ago•0 comments

Brazil's first arid zone is a stark warning for the whole country

https://www.theguardian.com/global-development/2025/dec/28/brazil-first-arid-zone-stark-warning-f...
2•pera•8m ago•1 comments

Show HN: Writing USB Device Firmware with Raspberry Pi Pico and TinyUSB

https://www.youtube.com/playlist?list=PL4C3a7zUGIuYu48KsA3krgm7rtLJwse03
1•madrajib•9m ago•0 comments

Wall Street is stealing from volunteer fire departments [video]

https://www.youtube.com/watch?v=t7GXVscHPfQ
1•xbmcuser•13m ago•0 comments

Success

https://snook.ca/archives/other/success
1•vishnuharidas•14m ago•0 comments

AI upheaval shows little sign of lessening

https://www.ft.com/content/728b03a4-cef3-4ee9-a421-d681998ef7d8
1•1vuio0pswjnm7•16m ago•0 comments

Kubernetes Garbage Collection

https://github.com/kube-zen/zen-gc
1•kubezen•17m ago•0 comments

I got tired of buying bad US B2B leads, so I built my own

https://rangelead.com/
1•RangeLead•17m ago•0 comments

'Year in review: AI's cultural surprises – and failures'

https://thenewstack.io/year-in-review-ais-cultural-surprises-and-spectacular-failures/
1•MilnerRoute•17m ago•0 comments

Why your AI companion is not your friend

https://www.ft.com/content/f3658db4-0bd5-4a0e-af9f-8f7a14f05603
2•1vuio0pswjnm7•17m ago•0 comments

A visual essay on octopi and falcons

https://joshfonseca.com/blogs/favorite-animals
1•vuciv•19m ago•0 comments

Thalassophobia

https://en.wikipedia.org/wiki/Thalassophobia
1•sowbug•23m ago•1 comments

Show HN: Brain Browser with Agent IDE

https://github.com/notforyou23/COSMO_BrainStudio
1•notforyou23•26m ago•0 comments

Show HN: AI 3D Model Generator

https://3d-generator.com
2•jokera•29m ago•0 comments

PEP 761 – Deprecating PGP signatures for CPython artifacts (2024)

https://peps.python.org/pep-0761/
2•marksomnian•39m ago•2 comments

World's largest functioning musical instrument: Wanamaker Organ in Philadelphia

https://en.wikipedia.org/wiki/Wanamaker_Organ
2•bookofjoe•39m ago•0 comments

Fail Faster on Your Ideas

https://martianlantern.github.io/2025/12/fail-faster-on-your-ideas/
1•martianlantern•40m ago•0 comments

Show HN: I built a replit game where you need to kill debuggers[Glitch Survival]

https://glitch-survival.replit.app
2•altras•41m ago•1 comments

Chemistry Experiments: working virtual lab

https://chemistry-en.nobook.com/console/templates/resource
2•danboarder•44m ago•0 comments

Haskelling My Typst

https://unnamed.website/posts/haskelling-my-typst/
3•todsacerdoti•44m ago•0 comments

OpenVINO – open-source toolkit for optimizing and deploying AI inference

https://github.com/openvinotoolkit/openvino
3•peter_d_sherman•45m ago•0 comments

Automating Deception: Scalable Multi-Turn LLM Jailbreaks

https://arxiv.org/abs/2511.19517
2•PaulHoule•45m ago•0 comments

A reason to know more facts

https://blog.ninapanickssery.com/p/a-reason-to-know-more-facts
1•jger15•45m ago•0 comments

Show HN: Offline tiles and routing and geocoding in one Docker Compose stack

https://github.com/corviont/monaco-demo
2•packet_mover•45m ago•1 comments

Rust macro to generate AI code at compile-time

https://github.com/germangb/ai-bindgen
2•michidk•47m ago•0 comments