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The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
1•bookofjoe•1m ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•3m ago•2 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
1•sara_builds•4m ago•0 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•5m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•8m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•9m ago•0 comments

Hello

1•otrebladih•11m ago•0 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
2•blacktulip•13m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
1•lasgawe•15m ago•0 comments

Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•17m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
2•gnufx•19m ago•0 comments

Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•23m ago•0 comments

.72% Variance Lance

1•mav5431•24m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•26m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•26m ago•1 comments

NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
1•Halinani8•27m ago•1 comments

Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
1•PaulHoule•28m ago•0 comments

SpaceKit.xyz – a browser‑native VM for decentralized compute

https://spacekit.xyz
1•astorrivera•29m ago•0 comments

NotebookLM: The AI that only learns from you

https://byandrev.dev/en/blog/what-is-notebooklm
2•byandrev•29m ago•1 comments

Show HN: An open-source starter kit for developing with Postgres and ClickHouse

https://github.com/ClickHouse/postgres-clickhouse-stack
1•saisrirampur•30m ago•0 comments

Game Boy Advance d-pad capacitor measurements

https://gekkio.fi/blog/2026/game-boy-advance-d-pad-capacitor-measurements/
1•todsacerdoti•30m ago•0 comments

South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
2•layer8•31m ago•0 comments

Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
1•atomic128•33m ago•2 comments

Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
1•sabujp•33m ago•2 comments

Google in Your Terminal

https://gogcli.sh/
1•johlo•34m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
1•hendler•35m ago•0 comments

Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•39m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
1•geox•39m ago•0 comments

Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•41m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•41m ago•0 comments
Open in hackernews

American Heart Association Revives Theory Light Drinking May Be Good for You

https://www.nytimes.com/2025/12/16/health/alcohol-heart-disease-cancer.html
13•bookofjoe•1mo ago

Comments

bookofjoe•1mo ago
https://archive.ph/viuKG
DetectDefect•1mo ago
The western diet has become so horrible and disease-inducing, that alcohol displacing some those calories has a net positive effect - truly an impressive "accomplishment".
jerlam•1mo ago
There was a questionable claim going around that beer was healthier than soda.

I don't really believe it especially when you take into account results like car crashes, but there is a figment of truth in it.

amanaplanacanal•1mo ago
If you remove automobiles, I wouldn't be totally surprised if sugary soft drinks turned out to be worse than beer. Probably neither one is going to be good for you.
thisislife2•1mo ago
Beer may indeed be "healthier" than soda as the fermentation process used to make it does create microbial cells that may be beneficial for your gut health (https://fermentation.wsu.edu/alcohol-fermentation-products/b...). It's the alcohol content in it that makes it "unhealthy" for us, just as it is the excessive sugar in the soda that's really bad for us. (And, ofcourse, it also depends on how much of both you actually consume).
legitster•1mo ago
My takeaway is that whatever effect there is must be so small as to be meaningless. The issue has been so thoroughly studied for so many decades. Even the cancer risks associated with moderate alcohol barely exceed the confidence interval - we're just collecting noise along the way.
darubedarob•1mo ago
Worrying about foodsins and sacred purity rituals with superfoods, air- and waterfilters are just existentialism anti anxiety religions. This field of science could have been several millions fatherOurs..
khelavastr•1mo ago
What they mean is that light dual GABA agonism/glutamate(nmda) antagonism is helpful.

Wait for a study to compare alcohol with ethyl ether (pure gaba agonist/nmda antagonist).

quickthrowman•1mo ago
If that’s the case, 0.25mg of alprazolam seems like a safer way to induce that than ethanol.
wildrhythms•1mo ago
Coincidence?

August 13, 2025 U.S. Drinking Rate at New Low as Alcohol Concerns Surge

>WASHINGTON, D.C. — The percentage of U.S. adults who say they consume alcohol has fallen to 54%, the lowest by one percentage point in Gallup’s nearly 90-year trend. This coincides with a growing belief among Americans that moderate alcohol consumption is bad for one’s health, now the majority view for the first time.

https://news.gallup.com/poll/693362/drinking-rate-new-low-al...

subjectsigma•1mo ago
I have witnessed this phenomenon happening in my own life and it is so utterly bizarre and wild to me that, while having zero evidence for this, I have to believe it’s some kind of astroturfing campaign by companies selling legal marijuana.

Many of my friends barely drink anymore or have reduced drinking significantly, all while saying things like: “Alcohol is so bad for you, it is expensive, it makes you lazy and sick, I prefer to just smoke weed now.” None of them will tolerate even the slightest criticism of weed, even though smoking it is also bad for you, also expensive, and (can) also make you lazy and sick.

This coincides with dozens of articles I’ve seen over the past year on various sites, including HN, claiming that alcohol is not safe in any amount, or some other nonsense.

The transformation happened so fast and so out-of-the-blue that I just don’t understand how it could possibly be genuine.

I stick by the age-old adages: what you put in your body is your business, and everything that isn’t green vegetables and meat should be consumed in moderation.

metadope•1mo ago
AHA! Medical approval in the nick of time!

Thank you @bookofjoe for bringing this to my attention. I have a bottle in my fridge that needs uncorking, and as Neil Young sings, Tonight's the night!

Sláinte and Happy New Year to all at HN!

jrm4•1mo ago
For any activity that humans have been doing for thousands of years, every "recent study" you've seen, good or bad, may be safely ignored.

I am unlikely to stop consuming milk, eggs, coffee or alcohol anytime soon, and certainly not based on recent "studies or theories."