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Using eBPF to load-balance traffic across UDP sockets with Go

https://vincent.bernat.ch/en/blog/2026-reuseport-ebpf-go
1•todsacerdoti•48s ago•0 comments

Sanctioned Oil Tankers Flee Venezuela in Defiance of U.S. Blockade

https://www.nytimes.com/2026/01/05/world/americas/oil-tankers-venezuela-blockade.html
1•thinkingemote•1m ago•0 comments

AWS Trainium vs. Nvidia CUDA for Medical Image Classification

https://www.medrxiv.org/content/10.64898/2025.12.23.25342933v1
1•salty_frog•3m ago•0 comments

Tenure//Track: An Academic Career Roguelike

https://tenuretrack.vercel.app/
1•goranmoomin•4m ago•0 comments

Show HN: The bedtime – Another little bedside clock I made

https://www.stavros.io/posts/i-made-another-little-bedside-clock/
5•stavros•5m ago•0 comments

Diving into Qualcomm's Upcoming Adreno X2 GPU with Eric Demers

https://chipsandcheese.com/p/diving-into-qualcomms-upcoming-adreno
1•rbanffy•7m ago•0 comments

Footprints in the Sand

https://twitter.com/iruletheworldmo/status/2007538247401124177
1•cpr•9m ago•0 comments

15 Years at XING – Reflections and a Farewell

https://www.stefanimhoff.de/15-years-xing/
1•Aldipower•10m ago•0 comments

Gramsci's Warning (2025)

https://www.insidehighered.com/opinion/columns/higher-ed-gamma/2025/03/17/old-world-dying-and-new...
1•robtherobber•13m ago•0 comments

Tell HN: EU soliciting feedback on law that could affect Open Access

3•Quanttek•18m ago•0 comments

Connecting portfolios, ATS, AI to simplify startup hiring

1•kathir05•19m ago•1 comments

Clawdbot Personal AI Assistant

https://clawdbot.com/
1•tobi_bsf•19m ago•0 comments

How to Do Great Work

https://paulgraham.com/greatwork.html
1•Anon84•19m ago•0 comments

AI Systems Engineering Patterns

https://blog.alexewerlof.com/p/ai-systems-engineering-patterns
1•weltview•23m ago•0 comments

List of Web Archiving Initiatives

https://en.wikipedia.org/wiki/List_of_web_archiving_initiatives
1•frozenseven•23m ago•0 comments

Either micromanage your people or lean on them

https://betterthanrandom.substack.com/p/either-micromanage-your-people-or
1•weltview•24m ago•0 comments

The Internet Was Built for Humans. Now It's for Agents

https://chiefting.substack.com/p/the-internet-was-built-for-humans
2•mpraz•31m ago•0 comments

Ghost Archive

https://ghostarchive.org/
1•frozenseven•35m ago•0 comments

Paris court finds 10 guilty of cyberbullying France's first lady Brigitte Macron

https://apnews.com/article/brigitte-macron-ruling-cyberbullying-france-5f78de63dc14f765e509a00400...
2•perihelions•35m ago•0 comments

Delta Electronics: Taiwan's Power Supply Giant [video]

https://www.youtube.com/watch?v=nRKxKz2eiOo
1•mgh2•38m ago•0 comments

Who Owns the Memory? Part 1: What Is an Object?

https://lukefleed.xyz/posts/who-owns-the-memory-pt1/
1•lalitmaganti•39m ago•0 comments

Perfect and Imperfect Shuffles

https://www.johndcook.com/blog/2026/01/01/perfect-shuffles/
1•ibobev•39m ago•0 comments

In-Shuffles and Out-Shuffles

https://www.johndcook.com/blog/2026/01/01/in-shuffle-out-shuffle/
1•ibobev•39m ago•0 comments

Freestyle Linked Lists Tricks

https://nullprogram.com/blog/2025/12/31/
1•ibobev•40m ago•0 comments

Ask HN: What kind of side projects are you working on?

2•chistev•41m ago•0 comments

We Come to Know Earth

https://www.quantamagazine.org/how-we-came-to-know-earth-20250915/
2•nsoonhui•42m ago•0 comments

A Woman Who Predicted Tech Fascism – Paulina Borsook Was Right

https://www.youtube.com/watch?v=DL-kwZdkiOA
3•rasengan0•45m ago•0 comments

Show HN: A tiny tool that creates short business snapshots

https://frabjous-sundae-f249f4.netlify.app/
1•RafalPilla•45m ago•0 comments

Everything You Need to Know About Email Encryption in 2026

https://soatok.blog/2026/01/04/everything-you-need-to-know-about-email-encryption-in-2026/
2•tempodox•46m ago•0 comments

8bitDo Reveals Flip-Style iPhone Controller for Portrait Mode Gaming

https://www.macrumors.com/2026/01/05/8bitdo-iphone-controller-portrait-gaming/
1•tosh•46m ago•0 comments
Open in hackernews

Not for human consumption

https://vectorculture.substack.com/p/not-for-human-consumption
53•ashergill•1d ago

Comments

vintagedave•1d ago
Dupe? https://news.ycombinator.com/item?id=46465871
terribleperson•1d ago
I'm glad there are alternative to DNP. There was always someone re-'discovering' DNP in the bodybuilding community (and probably other communities), and it's really best left buried.
Fiveplus•1d ago
People reading two abstracts on PubMed and deciding they can manage their own hormonal pathways is terrifying. The regulatory state is slow and bureaucratic, yes, and its got its own problems, but it was built on a graveyard of people who took unverified compounds. When (not if) a bad batch kills a few dozen people in a telegram buying group, the crackdown will be draconian.
SecondHandTofu•1d ago
An alternate way to view the same situation is that the regulatory state being slow and bureaucratic is the cause of those ills. The more you over-regulate and make the official pathways too expensive by adding a million tiny costs, the less unreasonable it seems to abandon the official channel entirely.
rubyfan•1d ago
Yes and the fact that you have people looking for a cure to their ills will always draw unscrupulous parties to their money. The entire supplements industry is sort of a prototype for this with outrageous marketing often targeting vulnerable groups. I’d argue the professional marketing of unregulated substances makes the supplements industry a lot larger than it might organically be.
adrianN•1d ago
PCPs don’t have the capacity to follow all medical research either. They depend on a network of institutions and regulation to do their work. How do you propose to scale that without the bureaucracy?
vibrio•1d ago
I agreee with the caution. I am not endocrinologist enough to guess what may happen and when. Because of the level of variably in all that is being experimented with, my guess is there may be a slower burn rather than explosion of odd toxicities. It does feel like stuff will happen.
jrm4•1d ago
I'm partial to the idea that we should think of these people as heroic. No way in hell I'd ever do anything like this, but people choosing to do this to their own bodies and essentially absorbing all of the risk is arguably valuable.

Certainly more important than other definitely dangerous activities like wingsuits and motorcycles.

readthenotes1•1d ago
A family member was poisoned for life by taking tryptophan sold at GNC.

Was hen heroic? No, just gullible.

m_a_g•1d ago
I’m glad there are this many early adopters. Thanks to them, in 3 to 5 years, all the side effects will be known, including the long-term effects, so I’ll be able to make an informed decision with the support of doctors rather than Claude. I’ll have access to regulated official compounds rather than underground lab compounds that can kill many people with one faulty batch. Please, continue doing what you’re doing, folks!
vibrio•1d ago
Will side effects for hormonal and gene therapy approaches be shaken out in just 3-5 years? For gene therapy, the rare blood cancers associated with car-t or bluebirdbio suggest maybe not. Maybe they remain rare, but as scale and flexibility of use increases, how that may evolve. Hormones are a whole different calculation. With the creative and dosing, combinations, and applications I’m not sure how many from conclusions will be available. I’m not judging good/bad here, I’m just thinking that this “democratization” of medicines (maybe otherwise not available to some) will increase access, with both risks and benefits.
cogman10•1d ago
> all the side effects will be known

I wish there were some good that came out of this. But these are completely unusable results. It's uncontrolled and not being studied.

Did their testicles fall off because of LLM drug 32, drug 34, drug 2, or a combination of all the drugs they took at the same time? Or maybe it's a combination of their genetic makeup and drug 4.

It'd be like trying to glean any useful medical information from any drug addict. Was the heart attack caused by meth, huffing paint, or one too many cheese burgers? Who knows.

Roark66•1d ago
You know there are regulated labs you can send samples to and serious sellers (like the one I use) attach a testing certificate you can authenticate with the lab. So you know for sure what is it you're getting and what purity etc.

On the actual efficacy and safety fair point. But we're all adults here (I hope). And as for "society's consequences" other people mention most of these compounds are taken is such tiny amounts it is very unlikely they are harmful once they have been out for a couple of years and people have been taking them(for example 250ug every second day for bpc-157 my favourite compound that is proven by research to improve necrotic wound healing in mice and significantly improve injury recovery in my personal experience).

As for modification of hormonal pathways. Retatrutide is in a middle of human trials. There is no indication so far it is harmful. Personally I've not taken it (despite my doc literally pitching ozempic to me a month ago, my bmi is 31 and I never seriously tried to diet in my life - I decided to try "the natural way" first - to be fair the doc was also interested in the improvement in the glucose metabolism not just weight loss in my case). But I might in next 6 months if I don't get the results I want.

skywhopper•1d ago
I’m concerned you are overestimating the value of the certificate of authenticity you’re getting from your supplier. While you may be right that the compounds you intend to take can’t possibly be all that harmful, there’s a good chance what you’re getting may not be what you think, may not be entirely what you think, and likely contains other things that may be harmful, particularly over a longer period of time.
codeflo•1d ago
Am I misreading this, or is this person actually implying somewhere in the middle of this unreadable mess of an article that they feed their DIY blood test results into an LLM and then order whatever drugs the machine hallucinates in response? If so, I hope sane society doesn't have to pay for the consequences of this willful self-destruction.
anovikov•1d ago
Weirdly enough, i know a guy who's worth half a billion bucks and he's doing exactly that.
yapyap•1d ago
So..? wealth ≠ intelligence
jama211•1d ago
I believe that’s their point
anovikov•1d ago
Not sure about intelligence precisely, but i have a conviction that richest people are those who in general do things right. Which doesn't necessarily mean "in the smartest way", sometimes (effective) solutions they employ are quite dumb.
smilespray•1d ago
Seemed they were ingesting more than just weight loss drugs.
TZubiri•1d ago
I propose to delete this article from hackernews
rootsudo•1d ago
The community in question is https://x.com/frontiertower/status/1938258376913195251.

This is nothing new. Numerous “scenes” do the same. There’s the longevity scene connected to this one.

There’s the psychonaut scene. That’s a bit from the erowid/and misc scene of the early 2010s.

There’s the bodybuilding / gym scene which probably is the longest and oldest subset of members.

I’m not sure which niche communities I’m missing.

coffeebeqn•1d ago
Maybe I’ve been gone from SF for too long but this just sounds like a cult. With a LLM generated pitch
rootsudo•1d ago
It’s natural for these type of communities. It’s not really a cult in the traditional sense, there is enough evidence that some medication/chemicals are gatekeeped they are effective while there’s just enough evidence to prove how dangerous it can be.

It can be understood as hobby group that focuses on drugs instead of another topic. It’s a fine line between reckless and leading edge that most don’t follow imo but it’s a community with its own rules.

tokioyoyo•1d ago
Wild, because 2010s tech-hype scene was just people trying to one up each other to see who has the lightest carbon fiber bike.
Filligree•1d ago
Oh don’t get me started. I have a friend who jumped on that scene…

Well, six years after he bought it the bike’s frame cracked in half as he was parking it. Somehow he avoided that happening in traffic.

cadamsdotcom•1d ago
Side-stepping regulatory process forgoes the benefit of a highly refined system for determining safety and efficacy, that is obvious - but it also forgoes seller liability. Which means you have no one to sue.

Also why risk permanently destroying yourself. We each only get one human mind and one human body - it’s irrational to do something with so much downside risk.

xnx•1d ago
Related:

‘Chinese Peptides’ Are the Latest Biohacking Trend in the Tech World

https://archive.is/Pu1y3

instagib•1d ago
Maybe worth its own post since this one got flagged. It’s well written albeit scary.

[one day, she accidentally doubled her dose. “My hair started falling out after a month because I was malnourished,” Ms. Bowman said. “It made my heart rate go up 10 beats per minute at night.” Still, she plans to keep going.]

xnx•1d ago
https://news.ycombinator.com/item?id=46474456