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Looking for 4 Autistic Co-Founders for AI Startup (Equity-Based)

1•au-ai-aisl•1m ago•0 comments

AI-native capabilities, a new API Catalog, and updated plans and pricing

https://blog.postman.com/new-capabilities-march-2026/
1•thunderbong•2m ago•0 comments

What changed in tech from 2010 to 2020?

https://www.tedsanders.com/what-changed-in-tech-from-2010-to-2020/
2•endorphine•7m ago•0 comments

From Human Ergonomics to Agent Ergonomics

https://wesmckinney.com/blog/agent-ergonomics/
1•Anon84•10m ago•0 comments

Advanced Inertial Reference Sphere

https://en.wikipedia.org/wiki/Advanced_Inertial_Reference_Sphere
1•cyanf•12m ago•0 comments

Toyota Developing a Console-Grade, Open-Source Game Engine with Flutter and Dart

https://www.phoronix.com/news/Fluorite-Toyota-Game-Engine
1•computer23•14m ago•0 comments

Typing for Love or Money: The Hidden Labor Behind Modern Literary Masterpieces

https://publicdomainreview.org/essay/typing-for-love-or-money/
1•prismatic•15m ago•0 comments

Show HN: A longitudinal health record built from fragmented medical data

https://myaether.live
1•takmak007•17m ago•0 comments

CoreWeave's $30B Bet on GPU Market Infrastructure

https://davefriedman.substack.com/p/coreweaves-30-billion-bet-on-gpu
1•gmays•29m ago•0 comments

Creating and Hosting a Static Website on Cloudflare for Free

https://benjaminsmallwood.com/blog/creating-and-hosting-a-static-website-on-cloudflare-for-free/
1•bensmallwood•34m ago•1 comments

"The Stanford scam proves America is becoming a nation of grifters"

https://www.thetimes.com/us/news-today/article/students-stanford-grifters-ivy-league-w2g5z768z
1•cwwc•39m ago•0 comments

Elon Musk on Space GPUs, AI, Optimus, and His Manufacturing Method

https://cheekypint.substack.com/p/elon-musk-on-space-gpus-ai-optimus
2•simonebrunozzi•47m ago•0 comments

X (Twitter) is back with a new X API Pay-Per-Use model

https://developer.x.com/
3•eeko_systems•54m ago•0 comments

Zlob.h 100% POSIX and glibc compatible globbing lib that is faste and better

https://github.com/dmtrKovalenko/zlob
3•neogoose•57m ago•1 comments

Show HN: Deterministic signal triangulation using a fixed .72% variance constant

https://github.com/mabrucker85-prog/Project_Lance_Core
2•mav5431•58m ago•1 comments

Scientists Discover Levitating Time Crystals You Can Hold, Defy Newton’s 3rd Law

https://phys.org/news/2026-02-scientists-levitating-crystals.html
3•sizzle•58m ago•0 comments

When Michelangelo Met Titian

https://www.wsj.com/arts-culture/books/michelangelo-titian-review-the-renaissances-odd-couple-e34...
1•keiferski•59m ago•0 comments

Solving NYT Pips with DLX

https://github.com/DonoG/NYTPips4Processing
1•impossiblecode•1h ago•1 comments

Baldur's Gate to be turned into TV series – without the game's developers

https://www.bbc.com/news/articles/c24g457y534o
2•vunderba•1h ago•0 comments

Interview with 'Just use a VPS' bro (OpenClaw version) [video]

https://www.youtube.com/watch?v=40SnEd1RWUU
2•dangtony98•1h ago•0 comments

EchoJEPA: Latent Predictive Foundation Model for Echocardiography

https://github.com/bowang-lab/EchoJEPA
1•euvin•1h ago•0 comments

Disablling Go Telemetry

https://go.dev/doc/telemetry
1•1vuio0pswjnm7•1h ago•0 comments

Effective Nihilism

https://www.effectivenihilism.org/
1•abetusk•1h ago•1 comments

The UK government didn't want you to see this report on ecosystem collapse

https://www.theguardian.com/commentisfree/2026/jan/27/uk-government-report-ecosystem-collapse-foi...
5•pabs3•1h ago•0 comments

No 10 blocks report on impact of rainforest collapse on food prices

https://www.thetimes.com/uk/environment/article/no-10-blocks-report-on-impact-of-rainforest-colla...
3•pabs3•1h ago•0 comments

Seedance 2.0 Is Coming

https://seedance-2.app/
1•Jenny249•1h ago•0 comments

Show HN: Fitspire – a simple 5-minute workout app for busy people (iOS)

https://apps.apple.com/us/app/fitspire-5-minute-workout/id6758784938
2•devavinoth12•1h ago•0 comments

Dexterous robotic hands: 2009 – 2014 – 2025

https://old.reddit.com/r/robotics/comments/1qp7z15/dexterous_robotic_hands_2009_2014_2025/
1•gmays•1h ago•0 comments

Interop 2025: A Year of Convergence

https://webkit.org/blog/17808/interop-2025-review/
1•ksec•1h ago•1 comments

JobArena – Human Intuition vs. Artificial Intelligence

https://www.jobarena.ai/
1•84634E1A607A•1h ago•0 comments
Open in hackernews

Not for human consumption

https://vectorculture.substack.com/p/not-for-human-consumption
53•ashergill•1mo ago

Comments

vintagedave•1mo ago
Dupe? https://news.ycombinator.com/item?id=46465871
terribleperson•1mo ago
I'm glad there are alternative to DNP. There was always someone re-'discovering' DNP in the bodybuilding community (and probably other communities), and it's really best left buried.
Fiveplus•1mo ago
People reading two abstracts on PubMed and deciding they can manage their own hormonal pathways is terrifying. The regulatory state is slow and bureaucratic, yes, and its got its own problems, but it was built on a graveyard of people who took unverified compounds. When (not if) a bad batch kills a few dozen people in a telegram buying group, the crackdown will be draconian.
SecondHandTofu•1mo ago
An alternate way to view the same situation is that the regulatory state being slow and bureaucratic is the cause of those ills. The more you over-regulate and make the official pathways too expensive by adding a million tiny costs, the less unreasonable it seems to abandon the official channel entirely.
rubyfan•1mo ago
Yes and the fact that you have people looking for a cure to their ills will always draw unscrupulous parties to their money. The entire supplements industry is sort of a prototype for this with outrageous marketing often targeting vulnerable groups. I’d argue the professional marketing of unregulated substances makes the supplements industry a lot larger than it might organically be.
adrianN•1mo ago
PCPs don’t have the capacity to follow all medical research either. They depend on a network of institutions and regulation to do their work. How do you propose to scale that without the bureaucracy?
SecondHandTofu•1mo ago
I'm not in favour of getting rid of the bureaucracy, some of it is necessary, but we're way past the benefit.

I think most regulation is a concave quadratic function of regulations vs benefit. At zero regulation it can be very bad, but there also must be a point at which something is so smothered in regulation that doing anything is impossible. So there must be a maxima somewhere between the two points.

All I think is that the current state of drug regulation quite a long way to the right of that maxima, that doesn't mean I think we should remove it all to zero, or that some other things aren't to the left of it and need more regulation!

Probably most disagreements over this sort of thing are just people who disagree about which side of the maxima we're on.

vibrio•1mo ago
I agreee with the caution. I am not endocrinologist enough to guess what may happen and when. Because of the level of variably in all that is being experimented with, my guess is there may be a slower burn rather than explosion of odd toxicities. It does feel like stuff will happen.
jrm4•1mo ago
I'm partial to the idea that we should think of these people as heroic. No way in hell I'd ever do anything like this, but people choosing to do this to their own bodies and essentially absorbing all of the risk is arguably valuable.

Certainly more important than other definitely dangerous activities like wingsuits and motorcycles.

readthenotes1•1mo ago
A family member was poisoned for life by taking tryptophan sold at GNC.

Was hen heroic? No, just gullible.

m_a_g•1mo ago
I’m glad there are this many early adopters. Thanks to them, in 3 to 5 years, all the side effects will be known, including the long-term effects, so I’ll be able to make an informed decision with the support of doctors rather than Claude. I’ll have access to regulated official compounds rather than underground lab compounds that can kill many people with one faulty batch. Please, continue doing what you’re doing, folks!
vibrio•1mo ago
Will side effects for hormonal and gene therapy approaches be shaken out in just 3-5 years? For gene therapy, the rare blood cancers associated with car-t or bluebirdbio suggest maybe not. Maybe they remain rare, but as scale and flexibility of use increases, how that may evolve. Hormones are a whole different calculation. With the creative and dosing, combinations, and applications I’m not sure how many from conclusions will be available. I’m not judging good/bad here, I’m just thinking that this “democratization” of medicines (maybe otherwise not available to some) will increase access, with both risks and benefits.
cogman10•1mo ago
> all the side effects will be known

I wish there were some good that came out of this. But these are completely unusable results. It's uncontrolled and not being studied.

Did their testicles fall off because of LLM drug 32, drug 34, drug 2, or a combination of all the drugs they took at the same time? Or maybe it's a combination of their genetic makeup and drug 4.

It'd be like trying to glean any useful medical information from any drug addict. Was the heart attack caused by meth, huffing paint, or one too many cheese burgers? Who knows.

Roark66•1mo ago
You know there are regulated labs you can send samples to and serious sellers (like the one I use) attach a testing certificate you can authenticate with the lab. So you know for sure what is it you're getting and what purity etc.

On the actual efficacy and safety fair point. But we're all adults here (I hope). And as for "society's consequences" other people mention most of these compounds are taken is such tiny amounts it is very unlikely they are harmful once they have been out for a couple of years and people have been taking them(for example 250ug every second day for bpc-157 my favourite compound that is proven by research to improve necrotic wound healing in mice and significantly improve injury recovery in my personal experience).

As for modification of hormonal pathways. Retatrutide is in a middle of human trials. There is no indication so far it is harmful. Personally I've not taken it (despite my doc literally pitching ozempic to me a month ago, my bmi is 31 and I never seriously tried to diet in my life - I decided to try "the natural way" first - to be fair the doc was also interested in the improvement in the glucose metabolism not just weight loss in my case). But I might in next 6 months if I don't get the results I want.

skywhopper•1mo ago
I’m concerned you are overestimating the value of the certificate of authenticity you’re getting from your supplier. While you may be right that the compounds you intend to take can’t possibly be all that harmful, there’s a good chance what you’re getting may not be what you think, may not be entirely what you think, and likely contains other things that may be harmful, particularly over a longer period of time.
codeflo•1mo ago
Am I misreading this, or is this person actually implying somewhere in the middle of this unreadable mess of an article that they feed their DIY blood test results into an LLM and then order whatever drugs the machine hallucinates in response? If so, I hope sane society doesn't have to pay for the consequences of this willful self-destruction.
anovikov•1mo ago
Weirdly enough, i know a guy who's worth half a billion bucks and he's doing exactly that.
yapyap•1mo ago
So..? wealth ≠ intelligence
jama211•1mo ago
I believe that’s their point
anovikov•1mo ago
Not sure about intelligence precisely, but i have a conviction that richest people are those who in general do things right. Which doesn't necessarily mean "in the smartest way", sometimes (effective) solutions they employ are quite dumb.
smilespray•1mo ago
Seemed they were ingesting more than just weight loss drugs.
TZubiri•1mo ago
I propose to delete this article from hackernews
rootsudo•1mo ago
The community in question is https://x.com/frontiertower/status/1938258376913195251.

This is nothing new. Numerous “scenes” do the same. There’s the longevity scene connected to this one.

There’s the psychonaut scene. That’s a bit from the erowid/and misc scene of the early 2010s.

There’s the bodybuilding / gym scene which probably is the longest and oldest subset of members.

I’m not sure which niche communities I’m missing.

coffeebeqn•1mo ago
Maybe I’ve been gone from SF for too long but this just sounds like a cult. With a LLM generated pitch
rootsudo•1mo ago
It’s natural for these type of communities. It’s not really a cult in the traditional sense, there is enough evidence that some medication/chemicals are gatekeeped they are effective while there’s just enough evidence to prove how dangerous it can be.

It can be understood as hobby group that focuses on drugs instead of another topic. It’s a fine line between reckless and leading edge that most don’t follow imo but it’s a community with its own rules.

tokioyoyo•1mo ago
Wild, because 2010s tech-hype scene was just people trying to one up each other to see who has the lightest carbon fiber bike.
Filligree•1mo ago
Oh don’t get me started. I have a friend who jumped on that scene…

Well, six years after he bought it the bike’s frame cracked in half as he was parking it. Somehow he avoided that happening in traffic.

cadamsdotcom•1mo ago
Side-stepping regulatory process forgoes the benefit of a highly refined system for determining safety and efficacy, that is obvious - but it also forgoes seller liability. Which means you have no one to sue.

Also why risk permanently destroying yourself. We each only get one human mind and one human body - it’s irrational to do something with so much downside risk.

xnx•1mo ago
Related:

‘Chinese Peptides’ Are the Latest Biohacking Trend in the Tech World

https://archive.is/Pu1y3

instagib•1mo ago
Maybe worth its own post since this one got flagged. It’s well written albeit scary.

[one day, she accidentally doubled her dose. “My hair started falling out after a month because I was malnourished,” Ms. Bowman said. “It made my heart rate go up 10 beats per minute at night.” Still, she plans to keep going.]

xnx•1mo ago
https://news.ycombinator.com/item?id=46474456