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Matthew Shulman, co-creator of Intellisense, died 2019 March 22

https://www.capenews.net/falmouth/obituaries/matthew-a-shulman/article_33af6330-4f52-5f69-a9ff-58...
1•canucker2016•23s ago•1 comments

Show HN: SuperLocalMemory – AI memory that stays on your machine, forever free

https://github.com/varun369/SuperLocalMemoryV2
1•varunpratap369•1m ago•0 comments

Show HN: Pyrig – One command to set up a production-ready Python project

https://github.com/Winipedia/pyrig
1•Winipedia•3m ago•0 comments

Fast Response or Silence: Conversation Persistence in an AI-Agent Social Network [pdf]

https://github.com/AysajanE/moltbook-persistence/blob/main/paper/main.pdf
1•EagleEdge•3m ago•0 comments

C and C++ dependencies: don't dream it, be it

https://nibblestew.blogspot.com/2026/02/c-and-c-dependencies-dont-dream-it-be-it.html
1•ingve•4m ago•0 comments

Show HN: Vbuckets – Infinite virtual S3 buckets

https://github.com/danthegoodman1/vbuckets
1•dangoodmanUT•4m ago•0 comments

Open Molten Claw: Post-Eval as a Service

https://idiallo.com/blog/open-molten-claw
1•watchful_moose•4m ago•0 comments

New York Budget Bill Mandates File Scans for 3D Printers

https://reclaimthenet.org/new-york-3d-printer-law-mandates-firearm-file-blocking
1•bilsbie•5m ago•0 comments

The End of Software as a Business?

https://www.thatwastheweek.com/p/ai-is-growing-up-its-ceos-arent
1•kteare•6m ago•0 comments

Exploring 1,400 reusable skills for AI coding tools

https://ai-devkit.com/skills/
1•hoangnnguyen•7m ago•0 comments

Show HN: A unique twist on Tetris and block puzzle

https://playdropstack.com/
1•lastodyssey•10m ago•0 comments

The logs I never read

https://pydantic.dev/articles/the-logs-i-never-read
1•nojito•12m ago•0 comments

How to use AI with expressive writing without generating AI slop

https://idratherbewriting.com/blog/bakhtin-collapse-ai-expressive-writing
1•cnunciato•13m ago•0 comments

Show HN: LinkScope – Real-Time UART Analyzer Using ESP32-S3 and PC GUI

https://github.com/choihimchan/linkscope-bpu-uart-analyzer
1•octablock•13m ago•0 comments

Cppsp v1.4.5–custom pattern-driven, nested, namespace-scoped templates

https://github.com/user19870/cppsp
1•user19870•14m ago•1 comments

The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
2•bookofjoe•17m ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•20m ago•3 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
2•sara_builds•20m ago•1 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•21m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•25m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•26m ago•0 comments

Hello

2•otrebladih•27m ago•1 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
3•blacktulip•30m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
1•lasgawe•32m ago•0 comments

Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•33m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
3•gnufx•36m ago•0 comments

Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
1•nielstron•39m ago•0 comments

.72% Variance Lance

1•mav5431•40m ago•0 comments

ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
1•JSLegendDev•42m ago•0 comments

Encrypt It

https://encryptitalready.org/
1•u1hcw9nx•42m ago•1 comments
Open in hackernews

Covid-19 leaves a lasting mark on the human brain

https://news.griffith.edu.au/2025/12/16/covid-19-leaves-a-lasting-mark-on-the-human-brain/
42•amichail•1mo ago

Comments

rippeltippel•1mo ago
The article doesn't say what those lasting marks are, nor their possible effects. Does anyone have any details on that?
napkinartist•1mo ago
They link to the paper in the article: https://www.sciencedirect.com/science/article/pii/S266635462...
vizzier•1mo ago
Still fairly non specific, as science probably should be (the question was if there visible MRI detectable changes, not what specific downstream changes were apparent)

Interesting that if we can detect some of these changes with covid what other viruses might be doing to us up there.

euroderf•1mo ago
This sounds a bit like the opening scene of something science fiction-ey dreadful. Like, even Pluribus.
kazinator•1mo ago
> The NCNED brings together a critical mass of talented researchers and clinicians committed to improving the lives of the patients.

Of course, improving the lives of patients for $$$!

First you have to convince people that they have a problem, and their insurers that it's covered.

It's the perfect disease. Scare people into suspecting they have it. All the hypochondriacs will believe it. It's difficult to measure and impossible to confirm recovery; you can milk that cow to kingdom come.

defrost•1mo ago
It's not US Pharma here, it's an Australian University (a country that actively works to keep health costs low and outcomes high) doing work funded by two outcomes orientated charities:

* https://qbi.uq.edu.au/stafford-fox-medical-research-foundati...

* https://www.meresearch.org.uk/

It's difficult to see a Martin Shkreli exploiting warped U.S. regulatory incentives parallel.

Frieren•1mo ago
> Our study identified altered signal intensity, abnormal tissue microstructure, and imbalanced neurochemicals in long COVID and COVID-19 recovered healthy controls.

So, it seems that it has long lasting effects on everybody. The main difference is how severe are that effects.

> Structural MRI studies have also identified alterations in brain morphology among COVID-RHC, including reductions in grey matter volume, thickness and global brain volume when compared with healthy controls

That is scary.

> Furthermore, long-term follow-up studies are crucial to determine whether the identified brain changes are progressive, stable or dynamic over time.

This is interesting, thou. Is it permanent, it gets worse or better? That makes a big difference and it may also justify further studies and actions.

krackers•1mo ago
>Importantly, cognitive impairments are not limited to those with ongoing systemic symptoms; they are also evident in COVID-19 recovered individuals (COVID-RHC) who no longer report active symptoms, compared to healthy controls without SARS-CoV-2 infection (Non-COVID-HC) (Hampshire et al., 2021)

The finding was done in 2021, it's not clear to me if it's an issue years out or it's just a manifestation of post-viral syndrome. Also today there are unlikely to be any people who haven't been infected by sars-cov2

fractallyte•1mo ago
> Also today there are unlikely to be any people who haven't been infected by sars-cov2

We do exist... ;-)

throwaway290•1mo ago
Most covid19 infections are asymptomatic so unless you treat every day you can't know;)
AstralStorm•1mo ago
Well, even the antibody titre isn't foolproof (some people do not react or have their immune system later wiped). However having no antibody titre is pretty good sign you never had it. Not sure if there's a portable cheap blood test for it yet. Should be one, like for the active disease.
throwaway290•4w ago
I heard antibodies are not permanent? not sure
swed420•1mo ago
Yep. Anybody who wears a well-fitting N95 wherever they go is in a rather safe place.

Breakthrough infections are still technically possible, but quite unlikely.

swed420•1mo ago
> Is it permanent, it gets worse or better? That makes a big difference and it may also justify further studies and actions.

Some symptoms of long COVID do lessen over time. The problem is that anybody who doesn't take adequate preventative measures (vast majority) are constantly re-infecting themselves every 6-12 months, so their body never has a chance to recover.

Even vaccinated individuals are not safe. The only real protection is regular use of a well fitting N95 in public spaces, and making sure everyone in your household does the same.

DustinEchoes•1mo ago
Brain matter losses don’t usually get better.
readthenotes1•1mo ago
Similar changes from taking the vaccine?