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1•hiddenarchitect•1m ago•0 comments

Pitchfork: A devilishly good process manager for developers

https://pitchfork.jdx.dev/
1•ahamez•1m ago•0 comments

You Are Here

https://brooker.co.za/blog/2026/02/07/you-are-here.html
1•mltvc•5m ago•0 comments

Why social apps need to become proactive, not reactive

https://www.heyflare.app/blog/from-reactive-to-proactive-how-ai-agents-will-reshape-social-apps
1•JoanMDuarte•6m ago•1 comments

How patient are AI scrapers, anyway? – Random Thoughts

https://lars.ingebrigtsen.no/2026/02/07/how-patient-are-ai-scrapers-anyway/
1•samtrack2019•6m ago•0 comments

Vouch: A contributor trust management system

https://github.com/mitchellh/vouch
1•SchwKatze•6m ago•0 comments

I built a terminal monitoring app and custom firmware for a clock with Claude

https://duggan.ie/posts/i-built-a-terminal-monitoring-app-and-custom-firmware-for-a-desktop-clock...
1•duggan•7m ago•0 comments

Tiny C Compiler

https://bellard.org/tcc/
1•guerrilla•9m ago•0 comments

Y Combinator Founder Organizes 'March for Billionaires'

https://mlq.ai/news/ai-startup-founder-organizes-march-for-billionaires-protest-against-californi...
1•hidden80•9m ago•1 comments

Ask HN: Need feedback on the idea I'm working on

1•Yogender78•10m ago•0 comments

OpenClaw Addresses Security Risks

https://thebiggish.com/news/openclaw-s-security-flaws-expose-enterprise-risk-22-of-deployments-un...
1•vedantnair•10m ago•0 comments

Apple finalizes Gemini / Siri deal

https://www.engadget.com/ai/apple-reportedly-plans-to-reveal-its-gemini-powered-siri-in-february-...
1•vedantnair•11m ago•0 comments

Italy Railways Sabotaged

https://www.bbc.co.uk/news/articles/czr4rx04xjpo
3•vedantnair•11m ago•0 comments

Emacs-tramp-RPC: high-performance TRAMP back end using MsgPack-RPC

https://github.com/ArthurHeymans/emacs-tramp-rpc
1•fanf2•13m ago•0 comments

Nintendo Wii Themed Portfolio

https://akiraux.vercel.app/
1•s4074433•17m ago•1 comments

"There must be something like the opposite of suicide "

https://post.substack.com/p/there-must-be-something-like-the
1•rbanffy•19m ago•0 comments

Ask HN: Why doesn't Netflix add a “Theater Mode” that recreates the worst parts?

2•amichail•20m ago•0 comments

Show HN: Engineering Perception with Combinatorial Memetics

1•alan_sass•26m ago•2 comments

Show HN: Steam Daily – A Wordle-like daily puzzle game for Steam fans

https://steamdaily.xyz
1•itshellboy•28m ago•0 comments

The Anthropic Hive Mind

https://steve-yegge.medium.com/the-anthropic-hive-mind-d01f768f3d7b
1•spenvo•28m ago•0 comments

Just Started Using AmpCode

https://intelligenttools.co/blog/ampcode-multi-agent-production
1•BojanTomic•29m ago•0 comments

LLM as an Engineer vs. a Founder?

1•dm03514•30m ago•0 comments

Crosstalk inside cells helps pathogens evade drugs, study finds

https://phys.org/news/2026-01-crosstalk-cells-pathogens-evade-drugs.html
2•PaulHoule•31m ago•0 comments

Show HN: Design system generator (mood to CSS in <1 second)

https://huesly.app
1•egeuysall•31m ago•1 comments

Show HN: 26/02/26 – 5 songs in a day

https://playingwith.variousbits.net/saturday
1•dmje•32m ago•0 comments

Toroidal Logit Bias – Reduce LLM hallucinations 40% with no fine-tuning

https://github.com/Paraxiom/topological-coherence
1•slye514•34m ago•1 comments

Top AI models fail at >96% of tasks

https://www.zdnet.com/article/ai-failed-test-on-remote-freelance-jobs/
5•codexon•35m ago•2 comments

The Science of the Perfect Second (2023)

https://harpers.org/archive/2023/04/the-science-of-the-perfect-second/
1•NaOH•36m ago•0 comments

Bob Beck (OpenBSD) on why vi should stay vi (2006)

https://marc.info/?l=openbsd-misc&m=115820462402673&w=2
2•birdculture•39m ago•0 comments

Show HN: a glimpse into the future of eye tracking for multi-agent use

https://github.com/dchrty/glimpsh
1•dochrty•40m ago•0 comments
Open in hackernews

A 'Holy Grail' Sleep Apnea Pill Could Be on the Market Next Year

https://www.forbes.com/sites/amyfeldman/2026/01/12/a-holy-grail-sleep-apnea-pill-could-be-on-the-market-next-year/
15•cebert•3w ago

Comments

A_D_E_P_T•3w ago
A weirdly low-information article.

If anybody's curious, the drug is called AD109. It combines "an antimuscarinic, aroxybutynin (2.5 mg), with a selective norepinephrine reuptake inhibitor, atomoxetine (75 mg)." https://www.sciencedirect.com/science/article/pii/S245186542...

Atomoxetine is an old generic.

Aroxybutynin is (R)-Oxybutynin. Oxybutynin is an ancient (>50 year old) generic. Wikipedia notes that "the (R)-enantiomer is a more potent anticholinergic than either the racemate or the (S)-enantiomer, which is essentially without anticholinergic activity at doses used in clinical practice. However, (R)-oxybutynin administered alone offers little or no clinical benefit above and beyond the racemic mixture."

If you have sleep apnea and live in a country where you can buy most drugs OTC, this "Holy Grail" is something you can put together for yourself by tomorrow! Simply combine oxybutynin 5mg with atomoxetine 75mg, and done.

PPoreddy•3w ago
This is a huge value add to the above article, thanks for the breakdown. I'm gonna ask my doc to review this literature and evaluate whether it's worth being prescribed ahead of time for a off label trial of my own.
al_borland•3w ago
> In very simplified terms, the medication works by waking up the brain stem, preventing full muscle relaxation in the throat, while allowing the brain itself to rest during sleep.

I wonder if this is the same level of restorative rest one would get without keeping the brain stem awake?

z3ugma•3w ago
This has been one of the things their latest clinical trials are pursuing, which is to see if the side effect of insomnia ends up outweighing the benefits of preventing the apnea
nubinetwork•3w ago
> (CPAP machines) it’s hated by most everyone who has to use it. Many people with sleep apnea refuse to try it or won’t even get diagnosed for fear they may have to.

After knowing I've had sleep apnea for the past 10 years, I actually want the damn machine... I'm sick of having to sleep 3-4 times a day and still feeling like trash.

onedognight•3w ago
The machine (AirSense 11) has been a god send for me. I can’t believe I waited so long. I haven’t slept a night without it since my first. I haven’t had to tweak any settings. It’s just worked. Sure it’s annoying to travel with, and you look odd while wearing it, but deep sleep is so worth it.
smackeyacky•3w ago
What happens when it’s impromptu sexy time? I can’t imagine the Darth Vader mask is conducive to marital relations
Doxin•3w ago
So take it off? You need it for sleeping, not for other activities.
thisislife2•3w ago
If your spouse thinks that a CPAP mask is an ornamentation that you wear to look good, you may have bigger problems in the relation ...
b3ing•3w ago
The purple sleep pills at Walmart work pretty good, but you might have to take 2+.

I’ve tried melatonin and magnesium and they never helped