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Brute Force Colors (2022)

https://arnaud-carre.github.io/2022-12-30-amiga-ham/
1•erickhill•1m ago•0 comments

Google Translate apparently vulnerable to prompt injection

https://www.lesswrong.com/posts/tAh2keDNEEHMXvLvz/prompt-injection-in-google-translate-reveals-ba...
1•julkali•1m ago•0 comments

(Bsky thread) "This turns the maintainer into an unwitting vibe coder"

https://bsky.app/profile/fullmoon.id/post/3meadfaulhk2s
1•todsacerdoti•2m ago•0 comments

Software development is undergoing a Renaissance in front of our eyes

https://twitter.com/gdb/status/2019566641491963946
1•tosh•2m ago•0 comments

Can you beat ensloppification? I made a quiz for Wikipedia's Signs of AI Writing

https://tryward.app/aiquiz
1•bennydog224•3m ago•1 comments

Spec-Driven Design with Kiro: Lessons from Seddle

https://medium.com/@dustin_44710/spec-driven-design-with-kiro-lessons-from-seddle-9320ef18a61f
1•nslog•4m ago•0 comments

Agents need good developer experience too

https://modal.com/blog/agents-devex
1•birdculture•5m ago•0 comments

The Dark Factory

https://twitter.com/i/status/2020161285376082326
1•Ozzie_osman•5m ago•0 comments

Free data transfer out to internet when moving out of AWS (2024)

https://aws.amazon.com/blogs/aws/free-data-transfer-out-to-internet-when-moving-out-of-aws/
1•tosh•6m ago•0 comments

Interop 2025: A Year of Convergence

https://webkit.org/blog/17808/interop-2025-review/
1•alwillis•7m ago•0 comments

Prejudice Against Leprosy

https://text.npr.org/g-s1-108321
1•hi41•8m ago•0 comments

Slint: Cross Platform UI Library

https://slint.dev/
1•Palmik•12m ago•0 comments

AI and Education: Generative AI and the Future of Critical Thinking

https://www.youtube.com/watch?v=k7PvscqGD24
1•nyc111•12m ago•0 comments

Maple Mono: Smooth your coding flow

https://font.subf.dev/en/
1•signa11•13m ago•0 comments

Moltbook isn't real but it can still hurt you

https://12gramsofcarbon.com/p/tech-things-moltbook-isnt-real-but
1•theahura•17m ago•0 comments

Take Back the Em Dash–and Your Voice

https://spin.atomicobject.com/take-back-em-dash/
1•ingve•17m ago•0 comments

Show HN: 289x speedup over MLP using Spectral Graphs

https://zenodo.org/login/?next=%2Fme%2Fuploads%3Fq%3D%26f%3Dshared_with_me%25253Afalse%26l%3Dlist...
1•andrespi•18m ago•0 comments

Teaching Mathematics

https://www.karlin.mff.cuni.cz/~spurny/doc/articles/arnold.htm
2•samuel246•21m ago•0 comments

3D Printed Microfluidic Multiplexing [video]

https://www.youtube.com/watch?v=VZ2ZcOzLnGg
2•downboots•21m ago•0 comments

Abstractions Are in the Eye of the Beholder

https://software.rajivprab.com/2019/08/29/abstractions-are-in-the-eye-of-the-beholder/
2•whack•22m ago•0 comments

Show HN: Routed Attention – 75-99% savings by routing between O(N) and O(N²)

https://zenodo.org/records/18518956
1•MikeBee•22m ago•0 comments

We didn't ask for this internet – Ezra Klein show [video]

https://www.youtube.com/shorts/ve02F0gyfjY
1•softwaredoug•23m ago•0 comments

The Real AI Talent War Is for Plumbers and Electricians

https://www.wired.com/story/why-there-arent-enough-electricians-and-plumbers-to-build-ai-data-cen...
2•geox•25m ago•0 comments

Show HN: MimiClaw, OpenClaw(Clawdbot)on $5 Chips

https://github.com/memovai/mimiclaw
1•ssslvky1•25m ago•0 comments

I Maintain My Blog in the Age of Agents

https://www.jerpint.io/blog/2026-02-07-how-i-maintain-my-blog-in-the-age-of-agents/
3•jerpint•26m ago•0 comments

The Fall of the Nerds

https://www.noahpinion.blog/p/the-fall-of-the-nerds
1•otoolep•28m ago•0 comments

Show HN: I'm 15 and built a free tool for reading ancient texts.

https://the-lexicon-project.netlify.app/
5•breadwithjam•30m ago•1 comments

How close is AI to taking my job?

https://epoch.ai/gradient-updates/how-close-is-ai-to-taking-my-job
1•cjbarber•31m ago•0 comments

You are the reason I am not reviewing this PR

https://github.com/NixOS/nixpkgs/pull/479442
2•midzer•32m ago•1 comments

Show HN: FamilyMemories.video – Turn static old photos into 5s AI videos

https://familymemories.video
1•tareq_•34m ago•0 comments
Open in hackernews

A 'Holy Grail' Sleep Apnea Pill Could Be on the Market Next Year

https://www.forbes.com/sites/amyfeldman/2026/01/12/a-holy-grail-sleep-apnea-pill-could-be-on-the-market-next-year/
15•cebert•3w ago

Comments

A_D_E_P_T•3w ago
A weirdly low-information article.

If anybody's curious, the drug is called AD109. It combines "an antimuscarinic, aroxybutynin (2.5 mg), with a selective norepinephrine reuptake inhibitor, atomoxetine (75 mg)." https://www.sciencedirect.com/science/article/pii/S245186542...

Atomoxetine is an old generic.

Aroxybutynin is (R)-Oxybutynin. Oxybutynin is an ancient (>50 year old) generic. Wikipedia notes that "the (R)-enantiomer is a more potent anticholinergic than either the racemate or the (S)-enantiomer, which is essentially without anticholinergic activity at doses used in clinical practice. However, (R)-oxybutynin administered alone offers little or no clinical benefit above and beyond the racemic mixture."

If you have sleep apnea and live in a country where you can buy most drugs OTC, this "Holy Grail" is something you can put together for yourself by tomorrow! Simply combine oxybutynin 5mg with atomoxetine 75mg, and done.

PPoreddy•3w ago
This is a huge value add to the above article, thanks for the breakdown. I'm gonna ask my doc to review this literature and evaluate whether it's worth being prescribed ahead of time for a off label trial of my own.
al_borland•3w ago
> In very simplified terms, the medication works by waking up the brain stem, preventing full muscle relaxation in the throat, while allowing the brain itself to rest during sleep.

I wonder if this is the same level of restorative rest one would get without keeping the brain stem awake?

z3ugma•3w ago
This has been one of the things their latest clinical trials are pursuing, which is to see if the side effect of insomnia ends up outweighing the benefits of preventing the apnea
nubinetwork•3w ago
> (CPAP machines) it’s hated by most everyone who has to use it. Many people with sleep apnea refuse to try it or won’t even get diagnosed for fear they may have to.

After knowing I've had sleep apnea for the past 10 years, I actually want the damn machine... I'm sick of having to sleep 3-4 times a day and still feeling like trash.

onedognight•3w ago
The machine (AirSense 11) has been a god send for me. I can’t believe I waited so long. I haven’t slept a night without it since my first. I haven’t had to tweak any settings. It’s just worked. Sure it’s annoying to travel with, and you look odd while wearing it, but deep sleep is so worth it.
smackeyacky•3w ago
What happens when it’s impromptu sexy time? I can’t imagine the Darth Vader mask is conducive to marital relations
Doxin•3w ago
So take it off? You need it for sleeping, not for other activities.
thisislife2•3w ago
If your spouse thinks that a CPAP mask is an ornamentation that you wear to look good, you may have bigger problems in the relation ...
b3ing•3w ago
The purple sleep pills at Walmart work pretty good, but you might have to take 2+.

I’ve tried melatonin and magnesium and they never helped