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When to treat (or not treat) a high cholesterol

https://www.sensible-med.com/p/when-to-treat-or-not-treat-a-high
2•brandonb•1h ago

Comments

pfdietz•1h ago
The cost of atorvastatin is about $100/year. The value of avoiding a cardiac event might be in the millions of dollars, so 25% reduction of a 3% risk sounds like a good deal.

This analysis ignores the issue of negative side effects. The most serious, rhabdomyolysis, occurs in about 0.1% of those taking statins. Liver issues are more common, and the cost of monitoring that might affect the cost/benefit ratio.

It would be nice to have a next generation statin that didn't have the muscle side effect (which appears to be independent of the primary mode of action of statins.)

Vibe Coding Safely: The Ultimate Guide to AI Dev with OpenCode and NixOS

https://grigio.org/vibe-coding-safely-the-ultimate-guide-to-ai-development-with-opencode-and-nixo...
1•grigio•3m ago•0 comments

Backseat Software

https://blog.mikeswanson.com/backseat-software/
1•ingve•4m ago•0 comments

Repair Advocates Name CES 2026's Most Anticonsumer Tech

https://thenewstack.io/repair-advocates-name-ces-2026s-most-anticonsumer-tech/
1•MilnerRoute•6m ago•0 comments

Chinese Fishing Boats Form Sea Barriers

https://www.nytimes.com/interactive/2026/01/16/world/asia/china-ships-fishing-militia-blockade.html
4•Alupis•7m ago•0 comments

A new Protocol Buffers generator for Golang

https://vitess.io/blog/2021-06-03-a-new-protobuf-generator-for-go/
1•fanf2•8m ago•0 comments

European Starlink competitor Eutelsat to launch more sattelites

https://www.reuters.com/business/media-telecom/starlink-rival-eutelsat-signs-deal-with-europes-ma...
1•Flundstrom2•9m ago•0 comments

60% of Legal Searches Now End Without a Click

https://talk24.ai/blog/ai-killing-legal-search
1•atreeleaf•10m ago•0 comments

Show HN: Built my portfolio in one Claude Code session – 145 repos, AI chat

https://tasteful-vibes.pages.dev
1•bmedwar•10m ago•0 comments

OpenCuff – Safe, capability-based execution for AI coding agents

http://opencuff.ai
1•kfirg•10m ago•1 comments

Everyone Will Be a Programmer

https://www.whileforloop.com/en/blog/2026/01/18/everyone-will-be-a-programmer/
1•lukas346•11m ago•1 comments

EU readies €93B tariffs in retaliation to Trump's Greenland threat

https://www.ft.com/content/b2872a49-3d43-4a55-a483-de7b19e8e436
1•mraniki•13m ago•1 comments

Interactive game/captcha/quest for web developers

https://ramys.ru/
1•ramaska•14m ago•0 comments

Deriving the Proton Radius Discrepancy from Vacuum Elasticity (0.02% Precision)

https://zenodo.org/records/18285286
1•Mr_Hoder•14m ago•1 comments

Emu8910: A tiny, fully featured AY-3-8910 emulator (TypeScript)

https://github.com/lunar-rf/emu8910
1•lunarjournal•18m ago•0 comments

Actuarial Notation

https://en.wikipedia.org/wiki/Actuarial_notation
1•srl•20m ago•0 comments

Show HN: I built Cyberpunk interface for my habits because Notion was too boring

https://playlife2.com
1•prabalsaxena•21m ago•0 comments

What comes after 'seeing is believing'

https://www.washingtonpost.com/opinions/interactive/2026/ai-photo-art-misinformation-conspiracy-t...
1•geox•21m ago•0 comments

The Lost Art of Structure Packing

http://www.catb.org/esr/structure-packing/
2•tosh•23m ago•0 comments

Show HN: Terravision – Generate Cloud architecture diagrams from Terraform code

https://github.com/patrickchugh/terravision
2•neogeno•26m ago•1 comments

A pandemic rescue became a 30-year debt trap

https://thehill.com/opinion/finance/5692543-small-business-loan-debt-trap/
9•iancmceachern•27m ago•0 comments

Help – GitHub Terminated Without Notice, No Broken Rules

https://github.com/nicoandmee/
1•todsacerdoti•29m ago•0 comments

America is slow-walking into a Polymarket disaster

https://www.msn.com/en-us/money/markets/america-is-slow-walking-into-a-polymarket-disaster/ar-AA1...
24•krustyburger•30m ago•9 comments

Show HN: LinuxMate generates reproducible Linux setup script

https://github.com/Henkster72/LinuxMate
2•henkster•31m ago•0 comments

Mystery of the Head Activator

https://www.asimov.press/p/head-activator
1•mailyk•32m ago•0 comments

Authorization API 1.0

https://openid.net/specs/authorization-api-1_0.html
2•mooreds•40m ago•0 comments

Megadroughts, Pt. 3: The Future (2021) (audio)

https://radiowest.kuer.org/agriculture-and-the-environment/2021-09-02/megadroughts-pt-3-the-future
2•mooreds•41m ago•0 comments

The Four Phases of Institutional Collapse in the Age of AI

https://kyla.substack.com/p/the-four-phases-of-institutional
2•mooreds•42m ago•0 comments

At This Office Park, Scamming the World Was the Business

https://www.nytimes.com/2026/01/13/world/asia/myanmar-scam-center.html
3•NN88•43m ago•0 comments

Show HN: HTTP:COLON – A quick HTTP header/directive inspector and reference

https://httpcolon.dev/
4•ultimoo•47m ago•2 comments

Flux 2 Klein pure C inference

https://github.com/antirez/flux2.c
11•antirez•48m ago•0 comments