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LicGen – Offline License Generator (CLI and Web UI)

1•tejavvo•43s ago•0 comments

Service Degradation in West US Region

https://azure.status.microsoft/en-gb/status?gsid=5616bb85-f380-4a04-85ed-95674eec3d87&utm_source=...
1•_____k•57s ago•0 comments

The Janitor on Mars

https://www.newyorker.com/magazine/1998/10/26/the-janitor-on-mars
1•evo_9•2m ago•0 comments

Bringing Polars to .NET

https://github.com/ErrorLSC/Polars.NET
2•CurtHagenlocher•4m ago•0 comments

Adventures in Guix Packaging

https://nemin.hu/guix-packaging.html
1•todsacerdoti•5m ago•0 comments

Show HN: We had 20 Claude terminals open, so we built Orcha

1•buildingwdavid•5m ago•0 comments

Your Best Thinking Is Wasted on the Wrong Decisions

https://www.iankduncan.com/engineering/2026-02-07-your-best-thinking-is-wasted-on-the-wrong-decis...
1•iand675•5m ago•0 comments

Warcraftcn/UI – UI component library inspired by classic Warcraft III aesthetics

https://www.warcraftcn.com/
1•vyrotek•7m ago•0 comments

Trump Vodka Becomes Available for Pre-Orders

https://www.forbes.com/sites/kirkogunrinde/2025/12/01/trump-vodka-becomes-available-for-pre-order...
1•stopbulying•8m ago•0 comments

Velocity of Money

https://en.wikipedia.org/wiki/Velocity_of_money
1•gurjeet•11m ago•0 comments

Stop building automations. Start running your business

https://www.fluxtopus.com/automate-your-business
1•valboa•15m ago•1 comments

You can't QA your way to the frontier

https://www.scorecard.io/blog/you-cant-qa-your-way-to-the-frontier
1•gk1•16m ago•0 comments

Show HN: PalettePoint – AI color palette generator from text or images

https://palettepoint.com
1•latentio•17m ago•0 comments

Robust and Interactable World Models in Computer Vision [video]

https://www.youtube.com/watch?v=9B4kkaGOozA
2•Anon84•20m ago•0 comments

Nestlé couldn't crack Japan's coffee market.Then they hired a child psychologist

https://twitter.com/BigBrainMkting/status/2019792335509541220
1•rmason•22m ago•0 comments

Notes for February 2-7

https://taoofmac.com/space/notes/2026/02/07/2000
2•rcarmo•23m ago•0 comments

Study confirms experience beats youthful enthusiasm

https://www.theregister.com/2026/02/07/boomers_vs_zoomers_workplace/
2•Willingham•30m ago•0 comments

The Big Hunger by Walter J Miller, Jr. (1952)

https://lauriepenny.substack.com/p/the-big-hunger
2•shervinafshar•31m ago•0 comments

The Genus Amanita

https://www.mushroomexpert.com/amanita.html
1•rolph•36m ago•0 comments

We have broken SHA-1 in practice

https://shattered.io/
10•mooreds•37m ago•3 comments

Ask HN: Was my first management job bad, or is this what management is like?

1•Buttons840•38m ago•0 comments

Ask HN: How to Reduce Time Spent Crimping?

2•pinkmuffinere•39m ago•0 comments

KV Cache Transform Coding for Compact Storage in LLM Inference

https://arxiv.org/abs/2511.01815
1•walterbell•44m ago•0 comments

A quantitative, multimodal wearable bioelectronic device for stress assessment

https://www.nature.com/articles/s41467-025-67747-9
1•PaulHoule•46m ago•0 comments

Why Big Tech Is Throwing Cash into India in Quest for AI Supremacy

https://www.wsj.com/world/india/why-big-tech-is-throwing-cash-into-india-in-quest-for-ai-supremac...
2•saikatsg•46m ago•0 comments

How to shoot yourself in the foot – 2026 edition

https://github.com/aweussom/HowToShootYourselfInTheFoot
2•aweussom•46m ago•0 comments

Eight More Months of Agents

https://crawshaw.io/blog/eight-more-months-of-agents
4•archb•48m ago•0 comments

From Human Thought to Machine Coordination

https://www.psychologytoday.com/us/blog/the-digital-self/202602/from-human-thought-to-machine-coo...
1•walterbell•49m ago•0 comments

The new X API pricing must be a joke

https://developer.x.com/
1•danver0•49m ago•0 comments

Show HN: RMA Dashboard fast SAST results for monorepos (SARIF and triage)

https://rma-dashboard.bukhari-kibuka7.workers.dev/
1•bumahkib7•50m ago•0 comments
Open in hackernews

When to treat (or not treat) a high cholesterol

https://www.sensible-med.com/p/when-to-treat-or-not-treat-a-high
2•brandonb•2w ago

Comments

pfdietz•2w ago
The cost of atorvastatin is about $100/year. The value of avoiding a cardiac event might be in the millions of dollars, so 25% reduction of a 3% risk sounds like a good deal.

This analysis ignores the issue of negative side effects. The most serious, rhabdomyolysis, occurs in about 0.1% of those taking statins. Liver issues are more common, and the cost of monitoring that might affect the cost/benefit ratio.

It would be nice to have a next generation statin that didn't have the muscle side effect (which appears to be independent of the primary mode of action of statins.)

reify•2w ago
No evidence that High cholesterol causes Cardiovascular Disease

1. Dietary Cholesterol and the Lack of Evidence in Cardiovascular Disease

  https://pmc.ncbi.nlm.nih.gov/articles/PMC6024687/
Cardiovascular disease (CVD) is the leading cause of death in the United States. For years, dietary cholesterol was implicated in increasing blood cholesterol levels leading to the elevated risk of CVD. To date, extensive research did not show evidence to support a role of dietary cholesterol in the development of CVD.

2, Doubt cast on wisdom of targeting ‘bad’ cholesterol to curb heart disease risk

British Medical journal

  https://bmjgroup.com/doubt-cast-on-wisdom-of-targeting-bad-cholesterol-to-curb-heart-disease-risk/
Decades of research have failed to show consistent benefit for this approach, say researchers

Setting targets for ‘bad’ (LDL) cholesterol levels to ward off heart disease and death in those at risk might seem intuitive, but decades of research have failed to show any consistent benefit for this approach, reveals an analysis of the available data, published online in BMJ Evidence Based Medicine.

The cholesterol panic is great for big pharma and the millions they make prescibing Statins.

For 20 + years I have lived on a high fat diet with 70% of my calories from fats.

My cholesterol has been quite normal

windowpains•2w ago
The non-sequiter conclusion you make will hopefully make others dismiss your post, as they should. You have normal cholesterol, the atherogenic hypothesis applies to those with high ldl, or more precisely high apo b. The bmj editorial you link hints that ldl alone may not be a good reason to prescribe statins, but the alternative is not to ignore cholesterol but to consider other factors like CAC. You also seem to not grasp the limited value of anecdotal information, and don’t say how much of your diet is saturated fat. A high fat diet from olive oil is different than a high fat diet from butter.