A small molecule inhibitor of 15-hydroxy prostaglandin dehydrogenase causes cartilage regeneration. I hope they fast-track it to human trials.
So this is one of those standard poor estrogen signaling downstream things and simply improving the estrogen signaling and you get improved cartilage. Anyone can do this today along with getting all of the other positive effects. Those with EDS who have say variants on their TNXA/B have poor production ability to start and so we do everything we can to improve their cartilage production as they can only make so much which include doing stuff like this.
Please explain
It is being trialed to prevent muscle weakness and some of those patients will have arthritis and they can be assessed for statistical improvement.
Same thing happened with GLP1
Getting vibes like a compsci paper that describes all about what an algo does but hides the sourcecode itself.
So they are using hyaluronic acid injections for patella tendonitis. Taking hyaluronic acid orally would probably take longer for effects compared to injections. Most people would prefer the injections because they feel safer for a doctor to do all the work. I prefer the tablets. If you have the money, I guess go for the injections. I would use the H.A. tablets. (With a tall glass of water, and do not take at the same time as blood-thinning medication, like pain killers or drugs.)
Cartilage Regrowth
Room Temperature Semiconductors
Quantum Computing
def generate(topic, year):
return f"Scientists have made a major breakthrough in {topic}"
Bingo!
:-D
Heard.
But if even one of their interests panned out it would be paradigm changing for millions and they’re doing it to save your lives not get a updoot on hacker news. They’re all pretty anonymous and understated Imo but i am a great fan and i would love for it to be the “year of” anything they’re studying. I listed a few and I’m sure there’s dozens I’m unaware of.
I’ve been thinking that this stuff is all more closely related than we think and that as they go down one of these paths they’re finding all this other stuff along the way, it’s genuinely fascinating.
Heart disease and failure is one of the biggest ways we meet our ends right now. There’s so much interplay between aging processes, ceasing t-cell production, shortening telomeres , that ties in together with this and im glad they see a bigger picture than me having another 20 years , too winded to stand up and piss or strapped to a bed hooked to tubes and groaning!
After Win11 Microsoft really did all they could to get us there this year.
I've had Windows as my main personal computer for practically forever, because of games. Before that it was DOS. That changed a couple months ago.
Literally just now--in preparation for this comment--I decided to try something I never tried before: I mounted my Win10 drive, picked an arbitrary old Windows game EXE (2006 "Prey" game demo), and launched it as a "non-Steam game" with just one little drop-down menu tweak... and it launched! I may get 10 FPS instead of 200, but that's more than I expected off the bat.
In the the "years of the Linux desktop" of my youth, I wasn't nearly as optimistic. In terms of more-recent games, I have little reason to keep my old drive for dual-boot purposes except for specific games that go out of their way to interfere with clumsy anti-cheat rootkits.
Notably absent:
The fat pill HIV fix Cystic fibrosis
We make fun of the stuff that hasn't been solved yet ("It's always ten years away!") while ignoring the things that were previously always ten years away until scientists cracked it.
It involved removing the poor mouses existing eye, so there was no net gain (still had a mouse with only 1 working eye), but I was hopeful progress would be made so I could get myself a working optic nerve.
Nope. No progress in 20+ years. Someone got a paper published and went on and did something else.
It is a relatively uncommon problem, for ~98% of children with a problem with their optic nerve, patching the opposite eye works to force the optic nerve to grow. I'm in the (un)lucky 2%!
Admittedly not the worst rare health problem to have.
That would be quiet something to feel that again.
Sometimes in a dream, I'll start running. I'll notice how magically effortless it feels. How wonderful to be able to run again. Then a little voice in the back of my head reminds me that this can't be real. It wakes me up every time.
It was a rough day when I opened Strava to log one of my physical therapy walks and realized that if I scroll down a bit, I can find a record of the longest run I will ever do.
I'm mostly at peace with it now. I'm grateful that at least I was into running for a while before I lost it, so at least I don't regret never having done it. And I never really enjoyed it then anyway. I just did it for health reasons and the sense of accomplishment.
I'm sorry for your suffering. I know what this longing feels like.
It really sucks when you break something and realise it might not ever go back to how it was before you break it (whether in how it feels or functions). I always had broken bones in my head as this thing that heal after a couple months and you're back to 100% :/ (also broke my ankle)
Then I slipped on a puddle and landed really wrong on my left ankle. :(
I don't know if I stuck my foot out and foot planted or the bike landed on it or what, but the end result was a tri-malleolar fracture with dislocation. Basically I tried to twist my foot off and broken the tips off my tibia and fibula in the process. I had a bunch of other complications after that: severe fracture blisters, nerve block rebound pain, infection, problems with wound healing, and then finally the cartilage crapped out and I got post-traumatic osteoarthritis.
> I always had broken bones in my head as this thing that heal after a couple months and you're back to 100% :/ (also broke my ankle)
Me too! This was my first broken bone. I thought I'd just go to the hospital, they'd patch me up, and I'd go on with my life. But then every appointment with the surgeon, the prognosis got worse and worse.
With the replacement, if everything goes well, then I should at least be able to walk, and hike, and dance without pain. But nothing high impact or putting a lot of torque on the ankle. No running, no intense sports. The door to that part of my life has closed.
I feel like it's worse with an ankle because if you don't break it they basically don't get arthritis, unlike a knee or hip; so you've lost more when you get ankle PTOA :'(.
I hope your TAR serves you well - they definitely sound like they've been getting better, so hopefully you get a good long while out of it.
Coincidentally, right around a same time, a friend of mine wiped out on his OneWheel and had a compound ankle fracture with dislocation. I don't recall how many malleoluses he broke, but it was pretty gnarly. But he's been healing well and it seems like his cartilage might survive OK. I'm happy for him but also envious.
> I feel like it's worse with an ankle because if you don't break it they basically don't get arthritis
It's crazy how well an ankle performs when you think about it. It is so much smaller than your hip or knee, and it takes even more impact force than those joints do when you run, and often while at weird angles. It's a miracle they work at all.
> they definitely sound like they've been getting better,
That's what I hear. If this had happened a decade ago, I'd probably getting a fusion now. Good luck on your recovery too.
Are there areas of medicine where mouse models have a much higher or lower success rate in human trials?
This is not being a contrarian, but a realist.
Not if pharma execs and shareholders have anything to say about that
It's discouraging to see these on HN and then realize that most never go anywhere, or are so far out you may not see it in your lifetime.
Maybe we should flag anything not already in a phase 3 trial :)
The researchers also tested cartilage taken from patients undergoing total knee replacement for osteoarthritis. After one week of treatment with the 15-PGDH inhibitor, the tissue showed fewer 15-PGDH-producing chondrocytes, reduced expression of cartilage degradation and fibrocartilage genes, and early signs of articular cartilage regeneration.
Once again, not in humans, in mice. We don't know if the same result happens in humans. At all. We need to proceed to clinical trials to determine if a result is indeed positive.
Reduce arthritis, get cancer?
We have decades of superb mouse health optimization research, it should be applied.
“ The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice. Investigators at any university, institute, company, or other organization are invited to recommend interventions for testing by submitting an application before the February deadline each year. Testing is carried out in the genetically heterogeneous UM-HET3 mouse stock at three sites — the Jackson Laboratory, the University of Michigan, and the University of Texas Health Science Center at San Antonio.”
https://www.nia.nih.gov/research/dab/interventions-testing-p...
blakesterz•2w ago
agumonkey•2w ago
random3•2w ago
IAmBroom•2w ago
rgun•2w ago
LoveMortuus•1w ago
seydor•2w ago
IAmBroom•2w ago
By analogy, "A drug is something that cures cancer in lab mice."
trebligdivad•2w ago
irishcoffee•2w ago
abdullahkhalids•2w ago
spwa4•2w ago
Especially when it comes to pregnancies we know more about a lot of animals than about humans. Why? Well pregnancies is how you multiply meat in animals, which is what farmers are interested in (and pay for). Which ironically also means animal pregnancies can be treated in case of trouble much more effectively.
Why pregnancies? Pregnancy changes a LOT of chemical processes in the body and so quite a bit of "normal" medical knowledge doesn't apply to pregnant women. Which has caused the medical establishment to declare anything that isn't explicitly tested on pregnant women as a no-go zone. So even problems and medications that we do know about, doctors won't apply them to pregnant women.
tominous•2w ago
AnimalMuppet•2w ago
laughing_man•2w ago
On a serious note, it seems like a whole lot of drugs work great on mice and not so much on people.
worthless-trash•2w ago