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Semaglutide improves knee osteoarthritis independant of weight loss

https://www.cell.com/cell-metabolism/abstract/S1550-4131(26)00008-2
71•randycupertino•1h ago

Comments

randycupertino•1h ago
Independent of weight loss, semaglutide (Ozempic) improves knee osteoarthritis by cartilage restoration, in both the mouse model and a small randomized clinical trial.

Old thinking was the benefit of GLP-1 drugs (like Ozempic) was solely from weight loss, however studies are showing there are other unique benefits. It's probably that semaglutide reduces inflammation allowing the body to repair and improves mitochondrial function in cartilage cells.

lysace•46m ago
Seems like a wonder drug to me. The benefits just keep piling up.

Where I live (Sweden), there's a perhaps surprisingly large portion of overweight/obesese people, especially in the countryside. Semaglutide could really do wonders here for quality of life and health.

Meanwhile, the newspapers keep pushing exceptional scare stories. The one that stuck with me from a few weeks ago went like 'I puked up my own poop.'

It is not yet generally subsidized, unless you have a diabetes type 2 diagnose.

mhurron•27m ago
> Seems like a wonder drug to me

Not really, it's that hormones don't do just one thing in the body. GLP-1 isn't just some weight management hormone.

> The one that stuck with me from a few weeks ago went like 'I puked up my own poop.'

That happens if you let constipation go on far too long, and is not something unique to GLP-1 meds.

gib444•25m ago
The constipation is REAL though. Like 10 plus days real. That scare story might be extreme but severe constipation is pretty common (and fecal vomiting can be a result of extreme constipation/impaction I believe)
lvspiff•19m ago
I've been taking the pill form of magnesium citrate and it helped SOO much im back to every day to every other day
gib444•3m ago
Nice. I added quite a lot of powder magnesium to my morning shake, did nothing.
lysace•16m ago
I'm on Wegovy (semaglutide for weight loss) since 2025-12-01. Zero side-effects besides losing 9 kg.

You need to stop eating just for the sake of eating. Eat when you're hungry, and slower than you're used to. For me, that is pretty much it.

Fogest•16m ago
Ultimately you get these extreme issues if you ignore a problem for too long. If you are becoming constipated and let it continue for many days on end without seeking some kind of treatment I feel that you are kinda to blame. I had some constipations at one point while on it and used some over the counter style fiber products and stool softeners to deal with the problem. If I ignored the problem of course I could potentially end up in these more extreme situations.

I think if people are choosing to use such medications they should make sure they are aware of the potential complications and are vigilant with their health to ensure these extreme side effects are avoided.

gib444•6m ago
Fibre and stool softeners did nothing for me. Nor increasing water. Nor exercise. Nor massaging my stomach. Nor senna

Only a magnesium drink ("Milk of Magnesia") or bisocodyl, neither of which are pleasant to take regularly as they result only in diarrhoea

It's hard to balance trying to let your body do its thing with less extreme method and resorting to the nuclear option. You also have to write off a day and not go anywhere after taking those

It's very much related to the drug and not just "ignoring" something

stavros•13m ago
For me, it really is a wonder drug. My blood test results were stellar when the drug worked for me. Unfortunately, with me, it either works and I get side effects, or it doesn't work at all. I feel minimal effects (and almost no weight loss) even on a 10mg dose.
RobotToaster•12m ago
I keep expecting for them to discover some horrible side effect. I wonder if people thought the same when they discovered antibiotics though.
foxyv•7m ago
To be fair, we have seen some long term effects from antibiotic use. Especially with regards to gut biomes. However, the long term effect of not using them is oftentimes death or permanent disability. Don't see nearly as many amputations from infected scratches these days thankfully.
sReinwald•13m ago
One thing I have noticed on Mounjaro is a (at least subjectively) significant decrease in impulse spending / buying random crap off Amazon. I have ADHD and that has been a real problem for quite a while - even with ADHD medication (Elvanse/Vyvanse in my case).

The part of Mounjaro that regulates the craving side of the weight loss equation (like reducing 'food noise' and the desire for sugary and fatty foods) seems to also affect other behaviors due to Mounjaro's effect on the brain's reward circuitry. I believe there are also early preliminary studies that indicate it can help with addictions like alcoholism.

Those drugs really are quite something. Shame they're so damn expensive. Insurance here in Germany is unfortunately legally prohibited from covering GLP-1 class drugs for weight loss unless you have a diabetes diagnosis.

thinkingtoilet•11m ago
That would go in line with what I've read of it helping people with mild addictions.
deinonychus•6m ago
That’s really neat.

I’m ashamed that I have this wish that I were overweight and had an excuse to try a GLP1 just to see how it would affect my impulse control with non-food habits.

I guess there’s not much stopping me from buying some unregulated drugs from the internet and self-experimenting, but I haven’t heard experiences from people deliberately using them for anything but weight.

CoastalCoder•46m ago
If it can somehow restore spinal disc function, I'm gonna start snorting the stuff.
nwienert•13m ago
It's a miracle drug for reducing immune overreach, like better than anything we know of. This is also completely outside of the weight loss effects. My lower back is improved by it.

It'll come to be known that these drugs are far better for people in a broad way than even thought today. They seem to have at least 4 effects that individually should be considered a "miracle."

JMKH42•10m ago
I have a bad disc, and while its still bad, a couple weeks of freestyle swimming workouts makes it not hurt for a year or two and lets me mountain bike comfortably again. Something to try if the usual stuff doesn't work, as it tends not to!

This was the disc between lumbar and sacrum. 1,000 ways to have a bad disc so results will vary a lot!

schnebbau•8m ago
I had a bulging lumbar disc - pure agony for 18 months. I had become used to carrying a lumbar pillow around with me everywhere I went. I couldn't lean forward for more than about 30 seconds without it being unbearable.

Then someone suggested I try dead hangs, stretching my hamstrings, and really cranking the McKenzie stretch. I'm not sure which one made the difference (all 3?), but pain was gone in 2 weeks.

Maybe it will help, maybe it won't. But since someone took a flyer telling me, I always share this with others in the small chance it helps them.

waffletower•37m ago
There are other clinical trials, such as one for Orforglipron, which are also studying this specifically.
lvspiff•15m ago
My psychiatrist is really interested in how it affects anxiety and depression as he has now seena number of improvements from a bunch of patients (including myself) who use the drug. Im on meds for both and only after i started on monjourno did i feel a signifigant change. The food cravings gone due to the nuerological effects but the stress levels lower as it seems to be impacting seratonin levels in ways as you increase dose.
ck2•11m ago
is Big Pharma going to invest in any of the other peptides or is it just one and done?

because the underground grey market seems to be snowballing for all kinds of diseases and symptoms

just very dangerous without any regulation

monkpit•6m ago
Typo in the title - “independant”
renewiltord•1m ago
One thing we have to remember is that we don’t know the long term effects of these things. Just like we don’t know the long term effects of the MMR 2. The first infants vaccinated with that are only in their fifties or early sixties. For all we know, the measles vaccine insta-kills people at 70.

We don’t know anything. We are complete ignorant floating through the void. If I drop a rock and it falls I cannot tell if the next rock I drop will fall. We can’t know. We are unknowing. Anything could happen.

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