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Genetic Targets, Financial Creativity: BridgeBio's Model for Drug Development
https://www.sciencedirect.com/science/article/pii/S135964462500296X
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randycupertino
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1h ago
Comments
randycupertino
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1h ago
Interesting look at BridgeBio's spoke and hub drug development model, using genetically validated targets, rNPV (risk-adjusted value) and PoTS (probability of success) to set go/no-go decisions.
X's new pure black dark mode hurts readability compared to the old dim theme
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danver0
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1m ago
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0 comments
MW-Class High-Altitude Wind Power System Completed Maiden Flight
https://www.eea.tsinghua.edu.cn/en/info/1038/3497.htm
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gnabgib
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6m ago
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0 comments
From 34% to 96%: The Porting Initiative Delivers – Hologram v0.7.0
https://hologram.page/blog/porting-initiative-delivers-hologram-v0-7-0
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bartblast
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8m ago
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1 comments
Rust: Program management update (January 2026)
https://blog.rust-lang.org/inside-rust/2026/02/11/program-management-update-2026-01/
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andrewstetsenko
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9m ago
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0 comments
Cees Nooteboom, Dutch author, dies aged 92
https://www.theguardian.com/books/2026/feb/11/cees-nooteboom-dutch-author-dies-aged-92
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Archelaos
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15m ago
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0 comments
Ask HN: Do you used a cloud based dev environment?
1
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asdev
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16m ago
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0 comments
Instagram Chief Says Social Media Is Not 'Clinically Addictive'
https://www.nytimes.com/2026/02/11/technology/adam-mosseri-instagram-addiction-trial.html
1
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greenburger
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16m ago
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0 comments
New AI Sensor 'Sniffs' Out Spectral Targets
https://newscenter.lbl.gov/2026/02/11/new-ai-sensor-sniffs-out-spectral-targets/
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gnabgib
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17m ago
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0 comments
We Forked Supabase to Fix Self-Hosted Postgres Experience
https://twitter.com/noctarius2k/status/2020754351396946284
1
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panrobo
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18m ago
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1 comments
A containment barrier that destroys the AI's reasoning if it tries to escape
https://www.researchgate.net/publication/400670258_Self-Referential_Quantum_Barriers_for_AGI_Cont...
1
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JakubCwi
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19m ago
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1 comments
Build Your Own Bankrbot-Style AI Agent (DIY) Using NeuyRouter and OpenClaw
https://finance.neuy.io/swap/docs/neuyrouter_bankrbot.aspx
1
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neuy
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19m ago
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0 comments
Frequent Diet Soda Intake Linked to Fourfold Increased Dementia Risk
https://www.medscape.com/viewarticle/frequent-diet-soda-intake-linked-fourfold-increased-dementia...
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wjb3
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25m ago
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1 comments
GPT-5 outperforms federal judges 100% to 52% in legal reasoning experiment
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6155012
4
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droidjj
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25m ago
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1 comments
LLM "reasoning" continues to be deeply flawed
https://garymarcus.substack.com/p/breaking-llm-reasoning-continues
3
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petethomas
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26m ago
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0 comments
Show HN: Undertale Text Box Generator
https://undertaletextboxgenerator.online
1
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ethanYIAI
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26m ago
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0 comments
Rare, dangerous side effects of some Covid-19 vaccines explained
https://www.science.org/content/article/rare-dangerous-side-effects-some-covid-19-vaccines-explained
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epistasis
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28m ago
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0 comments
But What to Do About It?
https://andys.blog/what-to-do/
1
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andytratt
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29m ago
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0 comments
One with the Environment
https://andys.blog/environment/
1
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andytratt
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30m ago
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0 comments
7 Days in the NICU
https://www.sonyasupposedly.com/nicu-diary/
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exolymph
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30m ago
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0 comments
Claude Code Skill That Shares Noteworthy Moments to Slack
https://quickchat.ai/post/claude-code-skill-watches-coding-sessions-shares-to-slack
2
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piotrgrudzien
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30m ago
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0 comments
Few people inevitably rise to the top
https://andytrattner.com/
1
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andytratt
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30m ago
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0 comments
Memory Layer for AI Agent
https://github.com/obicho/mem
1
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obicho
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33m ago
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1 comments
Algorithmic Liability: How Social Media Platforms Disclaim Responsibility
https://tostracker.app/analysis/algorithmic-liability
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tldrthelaw
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33m ago
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0 comments
How The New York Times uses a custom AI tool to track the "manosphere"
https://www.niemanlab.org/2026/02/how-the-new-york-times-uses-a-custom-ai-tool-to-track-the-manos...
3
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thetrustworthy
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35m ago
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0 comments
We built Vortex to fix team activation in PLG products
https://www.vortexsoftware.com/
1
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santiaparicio
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35m ago
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1 comments
Death of Software. Nah
https://hardcoresoftware.learningbyshipping.com/p/238-death-of-software-nah
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whobre
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36m ago
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0 comments
Show HN: Ignlnk, Hide the content to agents, not the files
https://github.com/No3371/ignlnk
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3371
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39m ago
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0 comments
How the hardware/software interface works (Linux Kernel)
https://offlinemark.com/how-the-hardware-software-interface-works/
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medbar
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42m ago
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0 comments
Most Americans don’t pay for news and don’t think they need to
https://www.niemanlab.org/2026/02/most-americans-dont-pay-for-news-and-dont-think-they-need-to/
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jaredwiener
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43m ago
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0 comments
Leo thought Guthrie's smart cam was disconnected, Google still had the tape
https://fortune.com/2026/02/11/privacy-concerns-nancy-guthrie-google-nest-camera-footage-kidnapping/
2
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c420
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45m ago
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2 comments
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randycupertino•1h ago