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Deploy RF-DETR Model on Rockchip NPU: Split Backbone on NPU, Detector on CPU

https://github.com/AlexanderDhoore/rfdetr-on-rockchip-npu
1•AlexanderDhoore•35s ago•0 comments

Show HN: AI PDF to PPT – Convert PDF Documents into Editable Presentations

https://genppt.ai/ai-pdf-to-ppt
1•polarisminor•1m ago•0 comments

Show HN: Promps – A visual AI prompt builder using Google Blockly

https://promps.org
1•BonoJovi•1m ago•0 comments

The Country of Geniuses That Doesn't Exist

https://techtrenches.dev/p/the-country-of-geniuses-that-doesnt
1•razoorka•1m ago•0 comments

An assembler that compiles to a printf loop

https://git.sr.ht/~sebsite/printfasm
1•PaulHoule•2m ago•0 comments

Show HN: Screenshader – Real-time shader overlay for your screen

https://github.com/xatuke/screenshader
1•satuke•2m ago•0 comments

Big Tech still dreams of mass surveillance – now people are pushing back

https://www.salon.com/2026/02/20/big-tech-still-dreams-of-mass-surveillance-now-people-are-pushin...
1•speckx•2m ago•0 comments

Hyperscalar AI Tax

https://www.cloudyali.io/blogs/ai-tax-hyperscaler-cloud-pricing-increase
1•heldsteel7•2m ago•1 comments

Show HN: I built a tamper-evident audit logging service to prevent DB rewrites

https://github.com/Ashish-Barmaiya/attest
1•ashish-barmaiya•3m ago•1 comments

Palantir Built the Data Layer That Right to Erasure Can't Touch

https://frontierlabs.substack.com/p/the-ai-is-the-last-thing-to-worry
1•muskanshafat•4m ago•0 comments

Show HN: VaultSandbox – Real SMTP testing that works on localhost (Apache 2.0)

https://github.com/vaultsandbox/gateway
1•vaultsandbox•4m ago•0 comments

Artemis rocket heads back to its hangar for repairs as moonshot put on hold

https://www.nbcnews.com/science/space/artemis-rocket-heads-back-hangar-repairs-moonshot-put-hold-...
1•bookofjoe•4m ago•0 comments

BrowserWing turns the browser actions into MCP commands Or Claude Skill

https://github.com/browserwing/browserwing
1•mountainview•5m ago•0 comments

Launch HN: TeamOut (YC W22) – AI agent for planning company events

https://app.teamout.com/ai
1•vincentalbouy•6m ago•0 comments

Agent Skills for Data Engineering (Airflow, Dbt, Analytics)

https://github.com/astronomer/agents
2•tayloramurphy•7m ago•0 comments

What are the best coping mechanisms for AI Fatalism?

2•johnb95•8m ago•1 comments

All New adobaRo – an execution-focused AI for global content workflows

1•adobaro•8m ago•0 comments

Show HN: Md files as B2B AI agent sandbox – no production data needed

https://publish.obsidian.md/frogy/30+Frogy+Telegram+Beta+Program/30-21+HN+%2B+Technical+Writing/2...
1•rolodexter2023•8m ago•1 comments

Show HN: Interactive visualization of X's feed algorithm – ML in browser

https://prabal.ca/x-algorithm/
3•prabal97•8m ago•3 comments

TLDraw plans to move their tests to a closed-source repo

https://github.com/tldraw/tldraw/issues/8082
1•switz•8m ago•0 comments

Show HN: EventDock – Webhook reliability for $29/mo (vs $490 alternatives)

https://eventdock.app/
1•kidsil•10m ago•0 comments

Show HN: Velar – Local privacy firewall for AI

https://github.com/ubcent/velar
1•ubcent•10m ago•0 comments

Show HN: I cut LLM API bill by 55% with a Python text compressor, no AI involved

https://agentready.cloud/hn
2•christalingx•10m ago•1 comments

Bullshit Benchmark: how do chatbots respond to silly questions?

https://github.com/petergpt/bullshit-benchmark
1•twistorial•11m ago•0 comments

Show HN: Skill or Kill – Can you spot the malicious AI agent skill?

https://skillorkill.dev/
2•jfaganel99•11m ago•1 comments

Spanish company releases free compressed AI model

https://techcrunch.com/2026/02/24/spanish-soonicorn-multiverse-computing-releases-free-compressed...
2•mastazi•14m ago•0 comments

Gleam is straightforward, predictable and stable

https://builders.perk.com/gleam-is-boring-so-i-went-to-a-conference-about-it-8f08a52c3de3
4•crowdhailer•14m ago•0 comments

A Round Up and Comparison of 10 Open-Weight LLM Releases in Spring 2026

https://magazine.sebastianraschka.com/p/a-dream-of-spring-for-open-weight
1•MindGods•15m ago•0 comments

Show HN: Seite static site generator with MCP server and Claude Code integration

https://seite.sh/
1•sanchezomar•17m ago•0 comments

Mitochondria May Be the Key to Longevity

https://www.nytimes.com/2026/02/19/well/mitochondria-longevity-health.html
2•bookofjoe•18m ago•1 comments
Open in hackernews

Show HN: MolBuilder – SMILES to manufacturing in pure Python (no RDKit)

https://github.com/Taylor-C-Powell/Molecule_Builder
2•taylorp661•1h ago

Comments

taylorp661•1h ago
Hi HN, I've been building MolBuilder -- a pure-Python molecular engineering toolkit that covers the full pipeline from molecular structure through retrosynthesis, reactor selection, safety assessment, cost estimation, and scale-up analysis.

Latest feature: substrate-aware condition prediction. It analyzes steric/electronic properties of your molecule and ranks compatible reaction templates with optimized conditions.

The install story is the differentiator: pip install molbuilder vs. RDKit's conda/C++ compilation. It's not trying to replace RDKit's computational accuracy -- it's solving a different problem: going from "I have a molecule" to "here's how to make it at scale."

1,280+ tests, Apache 2.0 license, Python 3.11+. Also available as a REST API.

  - PyPI: pip install molbuilder
  - Tutorials: https://github.com/Taylor-C-Powell/Molecule_Builder/tree/main/tutorials
Happy to answer questions about the implementation or design choices.