Thanks for reminding me of this. One of the all time greats.

Tool.

today an evolved monkey realized that the evolution of intelligence via genetic algorithms doesnt line up that well with the scientific trajectory of existence since the big bang , he then realized that his perception of existence would be exactly equivalent to that of a brain in a jar , his final realization was that all realizations are epheremal regardless as to how convincing or conclusive they may seem

Calling it the "pharmaceutical form" is borderline misinformation, considering it's just a common salt of LSD. You can get that outside the pharmacy. It's not like actual LSD is ever made in some dirty improv meth lab. Likewise, nobody expects researchers to buy their drugs on the streets. It's just LSD. This "say no to drugs" drug did the trick.

> The "surprising way" is by using a derivate of LSD.

What's the difference between a derivate and a derivative?

(I'm not being facetious, I'd really rather like to know)

Well... drugs are amazing. They're so amazing people will literally die for them.

Where do you go when you need to escape but can't actually go anywhere?

Inwards. Imagination, media, substances, meditation, solitude.

HN has its biases. For a while the health articles were about intermittent fasting. 15-20 years ago people were excited about polyphasic sleep.

The "neuroplasticity" which leads to a relative quietness presumably comes after the psychedelic experience.

Interestingly, the paper only lists the following adverse effects: visual perceptual changes, nausea, and headache. Given that the patients in the double-blind study were those who suffer from moderate to severe Generalized Anxiety Disorder, I could imagine some significant anxiety in the 200 µg active group!

The paper only reports significant results at the 100 µg and 200 µg dose level, not less, which seems like another strike against psychedelic microdosing. The pharmaceutical industry would love to find a magic psychedelic drug which doesn't result in the psychedelic experience, but it seems like that experience is the key to their mental impact.

No. That is a gross and deliberate mischaracterization in bad faith. Here is the full quote:

> Side effects were generally mild or moderate and included hallucinations, visual distortions, nausea, and headache. It's important to note, these were more prevalent using the highest dosage -- which we will not be using since it was found to be no more effective.