For my use case, you are making mountain out of a mole hill. I use AntiX linux with XFCE. I have to use zoom professionally with writing tablet on my laptop for hours daily. Never faced even tiny bit of a problem. Never have to install any drivers for tablet. Nothing. AntiX is fully usable and very fast Debian based OS and doesn't uses systemd. It uses runit.

It's completely possible to use a modern Linux without systemd until you need commercial software.

Comercial software assumes you are using systemd.