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Sylve – Proxmox Alternative by FreeBSD

https://sylve.io/
1•imbobbytables•57s ago•0 comments

The Revenge of the Data Scientist

https://hamel.dev/blog/posts/revenge/
1•hamelsmu•1m ago•0 comments

Nothing new to see here

https://feld.com/archives/2026/03/nothing-new-to-see-here/
1•guiambros•7m ago•0 comments

The Nap Room Didn't Love Me Back

https://www.thenation.com/article/society/the-nap-room-didnt-love-me-back/
1•mitchbob•7m ago•1 comments

Show HN: testing Ansible playbooks *fast*

https://github.com/lucasluitjes/ansible-lxd-boilerplate
2•lucasluitjes•9m ago•0 comments

Make Space for Every Voice: Reflect, Headline, Discussion

https://pointc.co/make-space-for-every-voice/
1•walterbell•12m ago•0 comments

A silly little trivia game I made

https://veritas.axiomatik.net/
1•stealth_dev•13m ago•0 comments

The American Soldier [pdf]

https://gwern.net/doc/psychology/1949-stouffer-theamericansoldier-v1-adjustmentduringarmylife.pdf
1•hbarka•14m ago•0 comments

Hardware Image Compression

https://www.ludicon.com/castano/blog/2026/03/hardware-image-compression/
1•luu•16m ago•0 comments

Humans Are Amazing

https://v5.chriskrycho.com/journal/humans-are-amazing/
3•walterbell•19m ago•0 comments

Usability – Catch common usability problems before user testing

https://www.userium.com/
1•calmnordic•21m ago•0 comments

Anthropic's 'Claude Mythos' Leak

https://www.coindesk.com/markets/2026/03/27/anthropic-s-massive-claude-mythos-leak-reveals-a-new-...
2•geoffbp•21m ago•0 comments

Basic Physics Engine in about 100 lines of pure JavaScript

https://slicker.me/javascript/physics/physics_engine.htm
2•thunderbong•24m ago•1 comments

Show HN: Canary – Monitor any URL for changes, get AI-powered intelligence

1•iambel0ved•24m ago•0 comments

First all-solid-state battery in production vehicles

https://www.donutlab.com/battery/
1•erickhill•25m ago•0 comments

Show HN: Free.ai

https://free.ai/
3•nadermx•26m ago•2 comments

MyHousingWiki: Crowdsourced Insights on Indian Apartments

https://www.myhousingwiki.com/
1•sawyerbilt•27m ago•0 comments

How Kimi, Cursor, and Chroma Train Agentic Models with RL

https://www.philschmid.de/kimi-composer-context
1•criscros•29m ago•0 comments

How a Mechanical Watch Works

https://ciechanow.ski/mechanical-watch/
1•josh-sematic•31m ago•0 comments

The first 40 months of the AI era

https://lzon.ca/posts/other/thoughts-ai-era/
2•jpmitchell•32m ago•0 comments

An investigation of the forces behind the age-verification bills

https://lwn.net/Articles/1062779/
2•greggyb•33m ago•0 comments

TruffleRuby

https://chrisseaton.com/truffleruby/
1•tosh•34m ago•0 comments

Further human + AI + proof assistant work on Knuth's "Claude Cycles" problem

https://twitter.com/BoWang87/status/2037648937453232504
19•mean_mistreater•35m ago•0 comments

Delve – Fake Compliance as a Service – Part II

https://deepdelver.substack.com/p/delve-fake-compliance-as-a-service-61d
1•spk_•36m ago•0 comments

Ricoh GR IV Monochrome Review

https://www.dpreview.com/reviews/ricoh-gr-iv-monochrome-review
1•reconnecting•39m ago•0 comments

Show HN: Nanopm – PM automation for Claude Code (audit → strategy → roadmap)

2•nmrtn•39m ago•0 comments

Show HN: GitHub Copilot Technical Writing Skill

https://github.com/chrisherczeg/tech_writer
2•chris_money202•40m ago•0 comments

Ember Forge: An alchemical smelting idle game built in Common Lisp

https://rootofcode.itch.io/ember-forge
2•yacin•42m ago•0 comments

California Judge Certifies Investor Class in Nvidia Crypto-Mining Lawsuit

https://www.law.com/therecorder/2026/03/26/california-judge-certifies-investor-class-in-nvidia-cr...
1•1vuio0pswjnm7•44m ago•0 comments

Show HN: A minimal terminal time tracker with AI analysis

https://github.com/ksketo/timectl
2•kostas_f•45m ago•2 comments
Open in hackernews

Founder of GitLab battles cancer by founding companies

https://sytse.com/cancer/
198•bob_theslob646•1h ago

Comments

anderber•1h ago
That's pretty amazing. I believe he's also a founder/investor in Kilo Code which I use and really like.
twostorytower•1h ago
Really awesome that he was able to do this and give back, but none of this would have been possible without his unfathomable wealth and access.
yieldcrv•1h ago
Feeling inspired?
croes•55m ago
It’s more like I hope more bad things happen to rich and powerful people so they start doing something against it. As long as it happens to ordinary people most of then hardly care.

Reminds me of the GOP who was against stem cell treatments until Reagan got Alzheimer‘s

rvz•1h ago
> ...but none of this would have been possible without his unfathomable wealth and access.

?

What's that supposed to mean? Is that bad?

You can do the same thing as he did, what's stopping you?

croes•54m ago
Wealth is mostly based on either luck and more often heritage.
rvz•26m ago
Not only Sid didn't come from any of those backgrounds, neither did the founder of Freshworks who literally started his company based on reading a hacker news comment. [0]

So I only see more excuses here.

[0] https://news.ycombinator.com/item?id=28336815

croes•5m ago
So it was luck
TobTobXX•54m ago
wealth and access that is merely fathomable
rvz•35m ago
You can literally apply to YC, just like Sid and now you are reading his story.

He did not come from any of those backgrounds.

Noumenon72•58m ago
That's not a "but". Because he developed wealth and access, this is possible for one person when before it wasn't possible for anyone. This is how societies developed everything from refined sugar to rockets, as they passed various thresholds where individuals could afford to try things out.
perch56•55m ago
According to some online sources his total wealth is under $3B. Hardly ‘unfathomable wealth’ IMO. Sure, billionaire territory but nowhere near the ultra-wealthy.
amazingamazing•54m ago
3 billion is ultra wealthy, you can't be serious.
perch56•50m ago
It’s entry-level billionaires club. The top 10 each hold $100B–$300B+, so the wealth distribution is extraordinarily skewed even within billionaires themselves. Musk is hundreds of times richer. Hardly obscenely rich.
amazingamazing•47m ago
I must be talking to AI
perch56•36m ago
This AI recommends you visualize inequality at scale and see the difference between 1B vs 300B. https://youtu.be/c7sr46hxVM4
amazingamazing•20m ago
The percentile ranking increase is greater between median human and 1B compared to 1B and 300B. Bad AI
tock•44m ago
It's entry-level obscenely rich club.
chaps•53m ago
Friend, $3B is unfathomable wealth for an individual.
perch56•48m ago
I can fathom 3B, I can’t fathom 300B
orf•30m ago
Yes, big number better, everyone gets it.

The point is that you’re deluding yourself if you think that there is any difference in terms of relative “unfathomability” between 3 billion and 300 billion.

3 billion generates more in interest per day than 99.99% of people make in a year. That’s unfathomable volumes of wealth for even the very rich.

dudul•18m ago
This comment left me speechless... There are just a bit over 3000 billionaires in the world, 900 in the USA. If $3B isn't "unfathomable wealth" I don't know what is.
peyton•54m ago
There are grad students babying organoids right now. Saturday morning. If you can work a pipette you can do this.
esafak•53m ago
This is an excellent use of his wealth and skills. Much better than Steve Jobs' response.

I remember reading a similar article about a (cancer?) patient who used 3D printing for his personalized cure.

fragmede•52m ago
And all of a sudden, I was bestowed with the greed to acquire more money than I can spend in a single lifetime. If I get cancer, I'd rather be rich and be able to do stuff like that, rather than die quietly.
Axoncode•1h ago
I hope he will feel better.
ashwinnair99•1h ago
Most people slow down when something like this hits. Starting companies is a very specific way of refusing to.
asim•1h ago
Kudos to Sid for trying it and hopefully it benefits others in the long run. Not everyone has the money, will or commitment to do this. My own father died with a battle of myeloma, a blood and bone marrow cancer, after 2 years, it wasn't the disease specifically that got him, it was the secondary conditions that caused irregular heart rhythm and eventually one day it stopped and no one was there to help. 2 stem cell transplants, rounds of chemo, almost full failure of kidneys. The cancer did its job. Ultimately what I'm saying, the medicine gives us time, but no one beats death. Maybe the treatment gives us time to come to terms with that, hopefully my dad did. I was in total denial. Anyway good luck to you Sid.

All the best to all the cancer survivors out there, and to the loved ones who lost them.

grokcodec•57m ago
https://time.com/7213490/why-are-young-people-getting-cancer...
storus•56m ago
Maybe it's time for him to give the metabolic cancer theory a go and try to bump up his mitochondrial function as much as possible? It's practically untestable due to science testing all compounds in isolation instead of a cocktail over longer period of time that can't be properly controlled even if it might be true. Every single cancer cell has a damaged mitochondria and often switching it properly on leads to cancer cell's apoptosis. He should also take desloratadine as some Swedish hospital observational study showed a significantly increased survivability on all tumor types with it. Some people had success with the combination of DCA, R-ALA, B1 HCl megadoses >2g, CoQ10 + PQQ, glucosidic astaxanthin, nattokinase/serrapeptase/lumbrokinase, low-dose aspirin, pancreatic enzymes and lactoferrin, with complete removal of fructose from the diet (as the cancer explosion can be correlated with years when fructose started getting introduced into diet in large quantities).
azinman2•50m ago
You said it’s untestable but then said a Swedish hospital did a study on it? I don’t see why things can’t be tested over a long term. There are many such studies.
storus•49m ago
Swedish hospital study was about desloratidine:

https://pubmed.ncbi.nlm.nih.gov/33550204/

Metabolic theory of cancer is untestable in practice as you can't control all variables over long time.

menno-dot-ai•54m ago
There's a crazy story in here where Sytse invested in a click chemistry cancer research startup (Shasqi) in 2017 and ends up becoming a customer six years later.

I sincerely hope it works out for him.

bob_theslob646•49m ago
It's mentioned in the slide deck on the url linked. I highly recommend clicking through all the slides. It's absolutely one of the most fascinating decks I've come across. His sheer will to want live is impressive and inspiring.
fumeux_fume•45m ago
The linked post about his treatment is basically a vanity article; low in useful information, but high in vague assertions and platitudes. There's also a link to a post griping about the red tape someone experienced while trying to self-treat their dog's cancer that's weird. I clearly live in a different world than these people.
bob_theslob646•37m ago
Here is a video if you want more detail.

https://forum.openai.com/public/videos/event-replay-from-ter...

"Event Replay: From Terminal to Turnaround: How GitLab’s Co-Founder Leveraged ChatGPT in His Cancer Fight"

dekhn•20m ago
This is a common trope in the tech field- successful tech person who is good at tech gets disease and wants to help cure it. It's easy to generate a lot of data these days (whole genome sequencing, various tests) but the reality is that turning that data into actionable knowledge is remarkably difficult.

Much of the red tape exists to help people avoid making common mistakes that aren't obvious until you've been through the process a number of times (other red tape just exists to gatekeep unnecessarily).

dsign•45m ago
When it comes to cancer, there is an awful lot of legacy thinking and "way things are done" taking lives. Starting with the so called "standard of care", which makes patient lose precious treatment windows while they wait for a possible miracle from "first-line drugs" from thirty and forty years ago which frankly are not that good. But it's hard to reform because the fraction of people who ever think about cancer as a problem to be solved is quite small; and it ought to be far larger, given that cancer is the second or even first leading cause of death across much of the world. I wish Elliot Hershberg every success.
SoftTalker•39m ago
I'm pretty much a pessimest when it comes to fighting cancer. I think it's just one of the bugs in our genetic code that evolution didn't shake out. I say that not as a biologist or anyone who has done any work in the field. But I've seen people close to me die of cancer and it seems like the treatement is almost worse than the disease. I agree that the standard first attacks are very crude and have broad systemic side effects and the attitude seems to be "you'll die without this so that doesn't matter."

I read some stuff about mRNA treatment a while ago that seemed like it might be promising.

pavas•19m ago
> I think it's just one of the bugs in our genetic code that evolution didn't shake out. I say that not as a biologist or anyone who has done any work in the field.

I'm just curious, do you know what the opinions about this stuff are from people that work in these fields, or that have dedicated their lives to it?

testaccount28•12m ago
i'm pretty much a pessimest [sic] when it comes to fighting smallpox. i think it just exploits one of the bugs in our genetic code that evolution didn't shake out.
NitpickLawyer•3m ago
> seems like the treatement is almost worse than the disease.

I think that's what the poster above you was saying. "Oldschool" chemo is basically poison, and the hope is that it kills off the cancer before the patient. But there are newer drugs that are extremely effective with way way way less side effects out there, depending on which type of cancer one has. Things like immunotherapy are really effective if you happen to match their targeted types of cancer, and some have basically 0 side effects, leading to a QoL improvement if they happen to work. People have gotten nobel prizes for some of these discoveries, it's really insane how far we've come in the last 30-40 years.

dominotw•42m ago
so many of these now. it is so sad and scary.

been thinking about prenuvo all the time now but not sure if thats going to help or make me more paranoid.

TaupeRanger•31m ago
Not really. Osteosarcoma rates have remained very stable for decades. Some young people are getting diagnosed with colon/breast cancer at increasing rates, but most of that comes down to better diagnostics and imagining, catching things at earlier ages.
nextos•38m ago
Previous discussion: https://news.ycombinator.com/item?id=47550016
appstorelottery•21m ago
This is the most supremely motivating post I've seen in a long time. I know what it is to be diagnosed with cancer, being rushed to surgery - it's amazing how quickly the medical-industrial complex can move once you've got a diagnosis (at least in Australia). I had a short period of contemplating terminally, because cancer claimed the life of most of my family. Thankfully, after surgery it was gone.

To see Sid use his motivation and resources to solve his own problem is the core message (IMHO) of the hacker community.

It makes me look at my own problem (Peyronies) in a different light; a disease which has affected my life in ways which cannot be overstated. Yet, all the money in the world right now can't fix Peyronies - yet in reading his journey my mind has been changed about this.

His slide title: "I'll talk to anyone, I'll go anywhere, and I can be there anytime" is certainly the mindset!

Thanks for posting this - I'm inspired to take similar action for Peyronie's. Anything is possible.

parsimo2010•12m ago
(slightly sarcastic) So we should give rich people diseases so they are incentivized to fund medical research?

Sid seems like a decent person. I'm glad that he's able to push cancer research forward on his own. Hopefully his work will make things better for everyone else with bone cancer. Seems like that is well under way. (and I guess I should recognize that he funded a cancer treatment company years before he knew he had cancer further reinforcing that he's not purely self-interested)

I'm a little melancholy that my aunt, who was a millionaire just not a mega-millionaire, didn't have the resources to do this before she died of cancer. She was able to pay for a high standard of care, but couldn't single-handedly fund teams of scientists to work on her case. I know she would have done so if she could, her biggest regret was not being around longer to see her grandkids grow up and she was very driven to watch over her family.

It is a little sad that the world's medical research apparatuses couldn't seem to fund this on their own. Not just the US medical system, but Europe and China also don't have better treatments until a rich guy came along. It seems that it's not for a lack of ideas, just that some of these ideas couldn't be funded. Is it that this type of bone cancer is super rare and the cost just isn't worth it? Or are we just under-funding at the level that several ideas with a likely positive ROI aren't able to get funded?

melling•4m ago
Why can’t we just ask our governments to spend more on research? Want some rich person to donate $100 billion on cancer research?

The US government and European governments could find that amount of money every year.