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No fine-tuning, no RAG – boosting Claude Code's bioinformatics up to 92%

https://github.com/jaechang-hits/SciAgent-Skills
2•jaechang•2h ago

Comments

jaechang•2h ago
SciAgent-Skills is a specialized plugin that boosts Claude Code (Opus 4.6) performance on the BixBench-Verified-50 bioinformatics benchmark from 65.3% to 92.0%.

The system utilizes 196 structured Markdown files covering genomics, drug discovery, and biostatistics. Unlike traditional RAG systems, it eschews complex vector databases and embedding pipelines in favor of simple on-disk files. The agent intelligently scans skill descriptions during planning and loads full technical details—including runnable code, parameters, and troubleshooting tables—only when needed.

With 72 toolkits, 53 database connectors, and various analysis pipelines, it can be easily installed by cloning the GitHub repository and using the --plugin-dir flag.

BrikPanel 2.0 – Free WooCommerce Admin Dashboard (Metorik Alternative)

https://wordpress.org/plugins/brikpanel-admin-panel-dashboard-for-woocommerce/
1•niyht•1m ago•0 comments

HFS+ Cannot Properly Handle 24TB Volumes on macOS

https://medium.com/@kivancgunalp/hfs-cannot-properly-handle-24tb-volumes-on-macos-a-cautionary-ta...
1•p_ing•2m ago•0 comments

Kepler's Laws of Planetary Motion

https://en.wikipedia.org/wiki/Kepler%27s_laws_of_planetary_motion
1•tosh•5m ago•0 comments

Fossils reveal many complex animals existed before the Cambrian Explosion

https://www.sciencenews.org/article/fossils-complex-early-animals-diversity
1•nobody9999•5m ago•0 comments

Hong Kong Disneyland Speedrun Guide

https://geohot.github.io//blog/jekyll/update/2026/04/09/hk-disneyland.html
1•Tomte•6m ago•0 comments

Fast Image AI White Background

https://fastimage.ai/white-background
1•lucas0953•8m ago•0 comments

Claude Use Cases

https://claude.com/resources/use-cases
1•vinhnx•11m ago•0 comments

The Bra-and-Girdle Maker That Fashioned the Impossible for NASA

https://thereader.mitpress.mit.edu/the-bra-and-girdle-maker-that-fashioned-the-impossible-for-nasa/
1•sohkamyung•12m ago•0 comments

A Day in the Life of an Enshittificator [video]

https://www.youtube.com/watch?v=T4Upf_B9RLQ
2•delduca•12m ago•0 comments

Study shows Alzhheimer's disease tau protein spreads through connected neurons

https://www.uab.edu/news/research-innovation/new-research-shows-that-tau-protein-spreads-through-...
3•netfortius•12m ago•0 comments

System Design Interviews for Software Developers with Examples

https://nemorize.com/roadmaps/system-design-interviews-for-software-developers-with-exampl
1•reverseblade2•15m ago•0 comments

Show HN: GlotShot – Generate App Store screenshots in 12 languages

https://apps.apple.com/app/glotshot/...
1•witnote•16m ago•0 comments

I replaced a $1K/month radar API with a self-hosted $7/mo EC2

https://github.com/tjamjam/noaa-radar-pipeline
1•terrencef413•16m ago•0 comments

Show HN: Obsidian AI Copilot – Bring Claude Code, OpenCode, etc. into Obsidian

https://github.com/spencermarx/obsidian-ai
1•mrxdev•17m ago•0 comments

Lenny's Memory: Building Context Graphs for AI Agents

https://neo4j.com/blog/developer/meet-lennys-memory-building-context-graphs-for-ai-agents/
2•eigenBasis•18m ago•0 comments

The first computer in East Africa had to wait for a bakery before it could boot

https://jkitsao.substack.com/p/east-africas-first-computers
1•kitsao•19m ago•0 comments

Primesieve: Fast Prime Number Generator

https://github.com/kimwalisch/primesieve
1•djoldman•20m ago•0 comments

Gravitational-Wave Induced Freeze-In of Fermionic Dark Matter

https://journals.aps.org/prl/abstract/10.1103/lr69-45v8
1•bookofjoe•22m ago•0 comments

Ask HN: Is anyone winning with Server-Driven UI (SDUI) in 2026?

1•divyanshub024•22m ago•0 comments

Population discontinuity in Paris Basin linked to evidence of Neolithic decline

https://www.nature.com/articles/s41559-026-03027-z
1•bryanrasmussen•24m ago•0 comments

OpenAI eyes staggered rollout of new model over cybersecurity risk

https://www.axios.com/2026/04/09/openai-new-model-cyber-mythos-anthopic
1•tosh•25m ago•0 comments

Sam Altman Says It'll Take Another Year Before ChatGPT Can Start a Timer

https://gizmodo.com/sam-altman-says-itll-take-another-year-before-chatgpt-can-start-a-timer-20007...
1•choult•26m ago•1 comments

LibreOffice State of the Project (April 2025 – March 2026)

https://blog.documentfoundation.org/blog/2026/04/09/libreoffice-state-of-the-project/
1•mariuz•27m ago•0 comments

The kenopsia of dead software [video]

https://www.youtube.com/watch?v=0YYH6oPPLkg
1•macgyverismo•29m ago•1 comments

Wit, unker, Git: The lost medieval pronouns of English intimacy

https://www.bbc.com/future/article/20260408-the-extinct-english-words-for-just-the-two-of-us
1•eigenspace•30m ago•0 comments

Neocities

https://neocities.org/
1•nc0•30m ago•0 comments

Privilege Escalation Attacks on GPUs Using Rowhammer

https://gpubreach.ca/
1•photon-torpedo•31m ago•0 comments

Shared Genetic Liability Across Systems of Psychiatric and Physical Illness

https://www.nature.com/articles/s41467-026-69218-1
1•gehwartzen•31m ago•0 comments

BoxWallet v0.3.4

https://github.com/richardltc/boxwallet2
1•richardltc•39m ago•0 comments

Ask HN: Local-first meetings recorder and transcriber?

1•dandaka•39m ago•1 comments