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Biopharma R&D pipeline shrinks for first time in 30 years

https://www.fiercebiotech.com/biotech/biopharma-rd-pipeline-shrinks-1st-time-30-years-report
5•randycupertino•2h ago

Comments

randycupertino•2h ago
> Roche had the most drugs in development, 262, largely because former pace-setter Pfizer axed assets, according to the report. Pfizer fell to No. 3 in the rankings after cutting its R&D pipeline from 271 to 257 molecules. AstraZeneca leapfrogged Pfizer and Novartis, adding 20 candidates to its pipeline to climb to No. 2.

> Novartis fell to No. 5 after trimming 10 programs, overtaken by Sanofi’s expanding pipeline.

Large drugmakers typically disclose programs only after they enter the clinic, meaning the data offer an incomplete snapshot of how pipelines are changing.

> Across the 25 companies with the largest pipelines, the total number of assets in development increased by 32. However, that figure is inflated by the addition of 30 programs to BioNTech’s pipeline. Among the top 15 companies, the number of active assets fell by 10.

Notably, a lot of smaller biopharmas are going under as their runways dry up.

Living Memory Inference

https://github.com/alash3al/loci
1•alash3al•2m ago•0 comments

YouTube Premium price increase to take effect in June

https://www.latimes.com/entertainment-arts/story/2026-04-10/youtube-premium-price-increase
1•obilgic•7m ago•0 comments

Open-source MCP server for LinkedIn

https://github.com/stickerdaniel/linkedin-mcp-server
1•arguflow•10m ago•0 comments

Hours Without Internet

https://bsky.app/profile/netblocks.org/post/3mj6hjlonjc2m
1•stupefy•11m ago•0 comments

Top% of users capture 61.5% of engagement in Hezbollah discourse on X

https://arxiv.org/abs/2603.26681
2•soufan•12m ago•0 comments

Several Mac mini and Mac Studio configs are now out of stock at Apple

https://9to5mac.com/2026/04/11/mac-mini-mac-studio-configs-completely-out-of-stock/
2•gnabgib•12m ago•0 comments

Prompt to App

https://prompttoapp.dev/
10•helloww•12m ago•2 comments

Get Users on Autopilot

https://www.usehotdrop.com/
1•Lucnyg•18m ago•0 comments

Producing The Perfect Token

https://blog.luminal.com/p/producing-the-perfect-token
1•jafioti•19m ago•0 comments

A general technique for automating NES games

https://tom7.org/mario/
2•azhenley•20m ago•0 comments

Show HN: PlaneFeed – scroll live flights like TikTok

https://planefeed.app/
1•mind1m•20m ago•0 comments

Canada's Liberal party adopts motion to restrict kids from social media

https://toronto.citynews.ca/2026/04/11/liberal-party-adopts-motion-to-restrict-kids-from-social-m...
1•EmbarrassedHelp•21m ago•0 comments

TB/cm² at zero retention energy – atomic-scale memory on fluorographane

https://zenodo.org/records/19513269
1•iliatoli•24m ago•0 comments

Apple Stops Accepting Orders for Some Mac Mini and Mac Studio Models

https://www.macrumors.com/2026/04/11/some-mac-mini-mac-studio-currently-unavailable/
4•dabinat•30m ago•1 comments

Dark Castle

https://darkcastle.co.uk/
3•evo_9•31m ago•0 comments

Show HN: Kern – Agents that do the work and show it

https://github.com/oguzbilgic/kern-ai
2•obilgic•31m ago•0 comments

Punching through internet censorship in 2026

https://neversleeps.moscow/publications/vpn_complexity.html
1•keddad•31m ago•0 comments

Show HN: Share how you hear yourself (on-device)

https://bone-conduction-imitator.vercel.app/
2•SpyCoder77•32m ago•0 comments

Honcho: Memory library for building stateful agents

https://github.com/plastic-labs/honcho
2•modinfo•32m ago•0 comments

Show HN: Sätteri, high-performance Markdown pipeline for JavaScript

https://github.com/bruits/satteri
1•Princesseuh•32m ago•0 comments

Show HN: Feedstock – Web Crawler for TypeScript Built on Bun and Playwright

https://github.com/tylergibbs1/feedstock
1•tylergibbs1•33m ago•0 comments

Show HN: A Better Internet

https://tomclancy.info/pages/abi-a-better-internet.html
1•tclancy•36m ago•0 comments

US Mobile now bundles Starlink home internet starting at $47/month

https://www.usmobile.com/home-internet/starlink
2•fastest963•42m ago•0 comments

For Chinese visa-seekers in the US, the path to good fortune lies in Chick-fil-A

https://apnews.com/article/china-student-visa-h1b-green-card-immigrant-talent-stem-0c86e70ae2074e...
2•rawgabbit•44m ago•0 comments

The Guinndex

https://guinndex.ai
2•wallflower•44m ago•0 comments

Why Obama did not stop NSA domestic surveillance (2015)

https://www.politico.com/magazine/story/2015/11/barack-obama-lawyer-in-chief-213342/
2•downbad_•45m ago•2 comments

ChatGPT Helped Plan Massacre

https://www.youtube.com/watch?v=IbG-JGdGniY
1•solid_fuel•47m ago•1 comments

Ask HN: Will AI Redefine Programming?

2•ploution•49m ago•4 comments

Getting chat-tuned models to act kinda like base models

https://iter.ca/post/model-baseify/
1•smitop•50m ago•0 comments

Show HN: Editing 2000 photos made me build a macOS bulk photo editor

https://apps.apple.com/us/app/rapidphoto-batch-crop-edit/id6758485661?mt=12
7•om202•51m ago•5 comments