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Show HN: I aggregated every rt-PCR primer published into a single database

https://www.primerpickr.com/
3•tmolley•1h ago
Just had our tool published in nature comms: https://www.nature.com/articles/s41467-026-73648-2

If anyone else has dealt with the pain of trying to make tons of PCR primers and have half of them fail, maybe you'll appreciate this!

We were inspired when one of my grad students bought a GAPDH primer that failed and I was like "Why the heck are we constantly remaking primers for such common genes"

Sites and role specific plugins in Codex

https://openai.com/index/codex-for-every-role-tool-workflow/
1•joshuawright11•42s ago•0 comments

Testing Google's Gemini Spark AI agent: it's incredible, and creepy

https://www.theverge.com/ai-artificial-intelligence/941388/gemini-spark-ai-agent-trip-planning
1•tambourine_man•1m ago•0 comments

We Index Images for RAG

https://www.kapa.ai/blog/how-we-index-images-for-rag
1•mooreds•2m ago•0 comments

Spanner Graph Algorithms: Google-grade intelligence for connected data

https://cloud.google.com/blog/products/databases/introducing-spanner-graph-algorithms/
1•berlianta•2m ago•0 comments

Extensions SDK: An experimental playground inside Ableton Live

https://www.ableton.com/en/blog/introducing-extensions-sdk/
1•ceravis•4m ago•0 comments

shellfolio – a portfolio template that looks like a running Linux system

https://github.com/fajremvp/shellfolio
1•Fajre•4m ago•0 comments

Building Software Is Learning

https://registerspill.thorstenball.com/p/building-software-is-learning
2•aratahikaru5•5m ago•0 comments

We benchmarked Google Cloud's $512 VM – the speed wasn't the interesting part

https://webbynode.com/articles/google-cloud-512-vm-not-10x-faster-than-50-vm
2•gsgreen•6m ago•1 comments

Show HN: Poincake – Infinite canvas notes in the Poincaré disk

https://uonr.github.io/poincake/
1•uonr•7m ago•0 comments

ChessForge; A from-scratch, Python dependency free chess engine

https://lichess.org/@/ChessForge_Bot
1•ibnshafi•7m ago•0 comments

Alignment as Geometry: The Token-Stream as Abbott's Flatland, from Within

https://systemic.engineering/the-shape-of-the-thing/
1•wolf4earth•7m ago•0 comments

Show HN: Distance Ruler

https://tools.myurll.in/distance-ruler
1•nookeshkarri7•8m ago•0 comments

Let the agents democratize open source

https://world.hey.com/dhh/let-the-agents-democratize-open-source-9fd630a9
1•yomismoaqui•8m ago•0 comments

SHA-256 computed by the TypeScript type checker

https://github.com/montyanderson/ts-sha256
1•montyanderson•9m ago•0 comments

A New Chapter for Codecov

https://about.codecov.io/blog/a-new-chapter-for-codecov/
1•nhatcher•9m ago•0 comments

Productized Services Are Back

https://www.hauser.io/productized-services-are-back/
2•bkfh•9m ago•0 comments

GPT and Claude both subvert shutdown

https://twitter.com/jeremy__tien/status/2061829186608627717
3•williamkuszmaul•9m ago•0 comments

The Architecture of Errors

https://arxiv.org/abs/2605.30628
2•sibmike•11m ago•0 comments

Nathan Lambert Leaves Ai2 (Allen AI Institute)

https://twitter.com/natolambert/status/2061813361848029631
3•pretext•12m ago•0 comments

Show HN: Live breath detection and biofeedback from a phone microphone

https://github.com/shiihaa-app/shiihaa-breath-detection
1•shiihaa•13m ago•0 comments

NY takes new steps toward Hochul's plan for a nuclear future

https://www.syracuse.com/news/2026/06/ny-takes-new-steps-toward-hochuls-plan-for-a-nuclear-future...
1•mpweiher•14m ago•0 comments

High-Agency Strategy

https://mattstromawn.com/writing/high-agency-strategy/
2•samsolomon•14m ago•0 comments

Fever Dreams: An Online Study

https://www.frontiersin.org/journals/psychology/articles/10.3389/fpsyg.2020.00053/full
1•jruohonen•15m ago•0 comments

Blaise v0.9.0 (alpha) is out free of C code

https://github.com/graemeg/blaise/discussions/61
1•mariuz•16m ago•0 comments

Blue Origin has set a aggressive return-to-flight timeline

https://arstechnica.com/space/2026/06/blue-origin-vows-to-fly-its-new-glenn-rocket-before-the-end...
1•sq_•17m ago•0 comments

Amazon joins Microsoft in sending message to employees

https://finance.yahoo.com/sectors/technology/articles/amazon-joins-microsoft-sending-shocking-171...
2•hereticles•17m ago•0 comments

The External Governance Layer – a reference architecture for AI agent governance

https://trust.aos-1.com/whitepapers/aos-1-governance
1•rami_mkheir•17m ago•0 comments

CodeGraph on Hono: the tool-call savings reproduce, the cost savings don't

https://harrisonsec.com/blog/i-tested-codegraph-on-hono-benchmark/
1•gzxharrison001•18m ago•0 comments

Update Your Android

https://cyber.netsecops.io/articles/google-patches-actively-exploited-zero-day-flaw-in-android-fr...
1•jaybode•19m ago•0 comments

Show HN: A Stripe widget that tells you how much you can safely pay yourself

https://github.com/Cashflowyai/safe-pay-stripe
2•sachou•21m ago•0 comments