frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Open in hackernews

The SSRI Debate Flares Again

https://www.psychologytoday.com/us/blog/the-biology-of-human-nature/202606/the-ssri-debate-flares-again
2•lovestory•55m ago

Comments

D-Machine•13m ago
All these policies actually sound good, SSRIs should not be first-line, as there is extremely limited evidence of meaningful effectiveness for anti-depressants generally.

Mmeta-analytic assessments of effect sizes show the observed effects are usually below what is required to count as a minimal clinically important difference, and antidepressants only target generally the "positive" symptoms of depression (sadness, anxiety) while doing little for the "negative" ones (anhedonia, lack of meaning, lack of motivation). They also have some serious side-effects, like emotional blunting and severe sexual dysfunction, the latter of which can persist for months even after stopping to take the drugs.

Even the usual excuses people make for these drugs ("Sure, the average effect is small, but they really help some people" and "Eventually the doctor finds the right one for you") are generally not supported by actual studies addressing these claims either.

There absolutely should be more monitoring and less careless prescribing of SSRIs and anti-depressants generally.

The Bloat

https://milkandcigarettes.com/notes/devlog/the-bloat
1•tarxzvf•17s ago•0 comments

Facing life-threatening miscarriage in Arkansas, calls to governor didn't help

https://www.cnn.com/2026/05/28/health/arkansas-miscarriage-abortion-ban-propublica
1•orwin•1m ago•1 comments

The Relaunch of the Old West and Why I Chose Vanilla PHP

https://blog.alexseifert.com/2026/06/02/the-relaunch-of-the-old-west-and-why-i-chose-vanilla-php/
1•SeenNotHeard•2m ago•0 comments

Batching API Calls

https://www.mostlypython.com/batching-api-calls/
1•speckx•3m ago•0 comments

Show HN: Mashines.dev – Live-migrate microVMs between hosts without restarting

https://mashines.dev/
1•ktaraszk•5m ago•0 comments

Impermeabiliza uses AI to modernize waterproofing in Valencia

https://impermeabiliza.net/
1•ignival•8m ago•0 comments

Microsoft unveils new AI models

https://microsoft.ai/models/
4•helloplanets•9m ago•0 comments

Tesla Cybertruck resale value plunges amid sales slump

https://www.msn.com/en-us/money/companies/tesla-cybertruck-resale-value-plunges-amid-sales-slump/...
4•petethomas•9m ago•1 comments

AI enthusiasts racing against time; AI skeptics are racing against entropy

https://charitydotwtf.substack.com/p/ai-enthusiasts-are-in-a-race-against
1•SLHamlet•11m ago•0 comments

AgentSight: System-wide AI agent tracing and monitoring with eBPF

https://github.com/eunomia-bpf/agentsight
2•tanelpoder•11m ago•0 comments

I believe a whole generation of developers miss how open source used to work

https://twitter.com/mitsuhiko/status/2062181646804152626
3•tosh•12m ago•1 comments

Gooey: A GPU-accelerated UI framework for Zig

https://github.com/duanebester/gooey
3•ksec•12m ago•0 comments

Network State Propaganda

https://capirates.substack.com/p/theyre-telling-you-exactly-what-theyre
3•tjcrowley•13m ago•0 comments

The 15-minute city is a dead end

https://blogs.lse.ac.uk/covid19/2021/05/28/the-15-minute-city-is-a-dead-end-cities-must-be-places...
1•Anon84•15m ago•0 comments

Book of Cron Job [fiction]

https://www.nature.com/articles/d41586-026-01716-0
2•apotheosized•15m ago•0 comments

Show HN: Hive Trust – Ed25519-signed benchmarks for every AI inference primitive

https://thehiveryiq.com/trust/
1•thehivery•16m ago•0 comments

Knowable – Open-Source Personal AI Tutor on macOS

https://knowable.ca/
2•samuelzxu•17m ago•1 comments

See SBA Loans Around You

https://www.loanround.com
1•zarie•18m ago•0 comments

Safe Made Easy Pt.2: Don't Fear the Ref

https://ergeysay.github.io/safe-made-easy-pt2.html
2•ergeysay•18m ago•0 comments

I benchmarked Opus 4.8 vs. GPT 5.5 on 2 open source repos

https://www.stet.sh/blog/opus-48-vs-gpt-55-vs-opus-47-vs-composer-25
3•bisonbear•18m ago•0 comments

The Download: Trump's new AI order, and smart glasses for warfare

https://www.technologyreview.com/2026/06/03/1138322/the-download-trump-ai-order-smart-glasses-war...
1•joozio•20m ago•0 comments

10M requests in my bot black hole

https://gladeart.com/blog/10-million-requests-in-my-bot-black-hole-here-is-some-information
1•itsJustTrivial•21m ago•0 comments

Stats from 30K AI debates: Opus 4.7 is the most influential model

https://opper.ai/ai-roundtable/stats
5•felix089•21m ago•1 comments

How to Build an ML Framework in Rust, from Scratch, in a Weekend

https://www.erikkaum.com/blog/zml/index.html
1•tosh•22m ago•0 comments

NASA Says Farewell to Maven Mars Mission

https://www.nasa.gov/news-release/nasa-says-farewell-to-maven-mars-mission-hosts-media-call-today/
2•ironyman•23m ago•1 comments

Why open standards matter for AI infrastructure

https://openenvelope.org/writing/open-standards-ai-infrastructure/
2•ashconway•24m ago•0 comments

Compiling Zig to RISC-V

https://www.erikkaum.com/blog/advent-05/index.html
3•tosh•25m ago•0 comments

Counterfeit G.Skill and V-Color DDR5 modules hit Chinese marketplaces

https://www.tomshardware.com/pc-components/dram/counterfeit-g-skill-and-v-color-ddr5-modules-hit-...
3•speckx•26m ago•0 comments

The Public Should Own Half of the Big A.I. Companies

https://www.sanders.senate.gov/op-eds/the-public-should-own-half-of-the-big-a-i-companies/
24•droidjj•26m ago•5 comments

If AI Data Centers Are So Great, Why Are They Being Built in Secret?

https://www.thebrockovichreport.com/p/if-data-centers-are-so-great-why
4•thisislife2•27m ago•0 comments