frontpage.
newsnewestaskshowjobs

Open Source @Github

fp.

Open in hackernews

Tell HN: Claude is completely unusable for biology

4•Protostome•1h ago
I've found that doing basic biology research with Claude has become extremely difficult. I'm not talking about anything remotely related to developing a bioweapon, just straightforward immunology questions that almost always end up being flagged.

I completely understand the need for guardrails, but in practice they can significantly reduce the tool's usefulness for legitimate scientific research. It sometimes feels like the model is better suited for "vibe coding" than for serving as a serious research assistant.

What's more funny is that you can use claude code together with molecular design models like RFdiffusion and Alphafold to develop a real bioweapon, but since this is in the realm of software, the prompts do not get flagged at all. Those models can even run on consumer GPUs so the limit of access is almost not there.

Has anyone else had a similar experience?

Is Vibe Coding Dead? Even Karpathy Is Moving On

https://www.forbes.com/sites/jodiecook/2026/06/12/is-vibe-coding-already-dead-even-karpathy-is-mo...
1•indigodaddy•1m ago•0 comments

SvGrid – A Svelte 5 data grid with a headless core and an MCP server

https://svgrid.com/
1•boikom•1m ago•0 comments

SAT-Based Approaches for the General High School Timetabling Problem (2017) [pdf]

https://dbai.tuwien.ac.at/staff/musliu/emird.pdf
1•tosh•2m ago•0 comments

AI SQL Advisor integrated into a famous database tool

https://github.com/Wisser/Jailer
1•rwisser•5m ago•0 comments

Psilocybin Unlocks Lost Memories in an Alzheimer's Patient

https://neurosciencenews.com/psilocybin-memory-alzheimers-30084/
1•giuliomagnifico•6m ago•0 comments

Services by Lifecycle

https://www.michaelnygard.com/blog/2018/01/services-by-lifecycle/
1•alex_brajkovic•7m ago•0 comments

Anthropic's Safety Superpower

https://stratechery.com/2026/anthropics-safety-superpower/
1•swolpers•11m ago•0 comments

Ask HN: Why are Spec-kit specs like that

1•pretorian_paul•14m ago•0 comments

Philippines now China's 2nd biggest market for solar panels

https://www.philstar.com/business/2026/05/29/2531211/philippines-now-chinas-2nd-biggest-market-so...
2•doener•15m ago•0 comments

Neuroscientists discover cognitive benefits of reading physical comic books

https://www.psypost.org/neuroscientists-discover-previously-unknown-cognitive-benefits-of-reading...
1•emot•16m ago•0 comments

When Tailwinds Vanish

https://foundersfund.com/2023/06/when-tailwinds-vanish/
2•ronfriedhaber•18m ago•0 comments

Returning to Zig

https://gracefulliberty.com/articles/return-to-zig/
1•kristoff_it•18m ago•0 comments

Why Reddit blocked unauthenticated JSON in 2026

https://medium.com/@tonywangcn/why-reddit-blocked-unauthenticated-json-in-2026-and-how-to-still-g...
2•tonywangcn•20m ago•0 comments

You probably don't need private PKI for internal infrastructure

https://www.certkit.io/blog/private-pki-internal-infrastructure
1•plopilop•21m ago•0 comments

Mid-tier US knives vs. cheap imports

https://www.paragon-knives.com/
1•bgzlsxaz•23m ago•0 comments

T1A Brings Its Full Data Stack to Dais 2026: 5 Products AndSubscription Giveaway

https://lakesentry.io/
1•tsyliya•26m ago•0 comments

Show HN: Fastembed-rs – Rust library for generating vector embeddings, reranking

https://github.com/Anush008/fastembed-rs
1•thoughtfullyso•30m ago•0 comments

Browser game about movie guessing

https://frameguesser.vercel.app/
1•mmschreiber•36m ago•0 comments

Nike Launches Sneaker Line with Russian Designer Who Backed Crimea Annexation

https://united24media.com/world/nike-launches-sneaker-line-with-russian-designer-who-backed-crime...
8•fodmap•38m ago•0 comments

Graphtatui: In terminal graph explorer made with ratatui

https://github.com/Sok205/graphtatui
2•sok205•40m ago•0 comments

Yield Curves and Volatility Surfaces Are Built in Modern Finance

https://medium.com/@DolphinDB_Inc/the-hidden-foundation-of-pricing-and-risk-how-ficc-curves-and-s...
2•Polly_Liu•41m ago•0 comments

CPMpy: Constraint Programming and Modeling library in Python, based on NumPy

https://github.com/CPMpy/cpmpy
1•tosh•42m ago•0 comments

Why Digital Twins Need Low-Latency Data Processing

https://medium.com/@DolphinDB_Inc/real-time-decision-making-how-ai-and-low-latency-computing-are-...
2•CrazyTomato•42m ago•1 comments

Githipedia – The Wiki for GitHub

https://github.com/Vendetaaaa/Githipedia
1•Vendeta•43m ago•1 comments

Show HN: I wrote a C++ ray tracer from scratch without AI

https://github.com/themartiano/luz
3•martiano•44m ago•1 comments

Ask HN: How do you handle browser tab overload?

1•formit34•44m ago•3 comments

Coversubstack-Zagreus=Whiterabbit.flexe

https://substack.com/@rootedinthought/note/c-276218913
1•dcmexpunksolar•48m ago•0 comments

LibAgar – Cross-platform GUI written in C

https://libagar.org/
2•0x0203•49m ago•0 comments

What are you looking for when reviewing LLM generated code?

2•gnunicorn•50m ago•1 comments

Ask HN: Developers, are you being forced into prompt-only engineering?

3•zerr•51m ago•0 comments