“Copper is essential for cellular energy production as it acts as a cofactor for cytochrome c oxidase, an enzyme that catalyzes the reduction
IMHO, Alz’s is a metabolic problem of low ATP. They call this a copper drug, but really it is just another way to deliver copper. They have been looking into this "drug" for ALS as well.
Copper dysfunction has already been noted in Alz’s.
The other important role for copper is that it is a co-factor for Dopamine beta-hydroxylase which turns dopamine into nor-epinephrine and epinephrine. This would explain the depression associated with Alz’s patients pre-diagnosis
"The pattern of increasing depression symptoms many years prior to dementia diagnosis reinforces the notion that the association between depressive symptoms and dementia in older adults may be primarily due to a shared common cause, or that depressive symptoms represent an early sign of dementia in the preclinical phase. Changes in specific depressive symptoms prior to dementia diagnosis will also be examined.. "
Noaidi•1h ago
Now me:
“Copper is essential for cellular energy production as it acts as a cofactor for cytochrome c oxidase, an enzyme that catalyzes the reduction
IMHO, Alz’s is a metabolic problem of low ATP. They call this a copper drug, but really it is just another way to deliver copper. They have been looking into this "drug" for ALS as well.
Copper dysfunction has already been noted in Alz’s.
The Role of Copper in Alzheimer’s Disease Etiopathogenesis: An Updated Systematic Review - https://www.mdpi.com/2305-6304/12/10/755
and
Brain copper may protect from cognitive decline and Alzheimer’s disease pathology: a community-based study - https://www.nature.com/articles/s41380-022-01802-5
The other important role for copper is that it is a co-factor for Dopamine beta-hydroxylase which turns dopamine into nor-epinephrine and epinephrine. This would explain the depression associated with Alz’s patients pre-diagnosis
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.100...
"The pattern of increasing depression symptoms many years prior to dementia diagnosis reinforces the notion that the association between depressive symptoms and dementia in older adults may be primarily due to a shared common cause, or that depressive symptoms represent an early sign of dementia in the preclinical phase. Changes in specific depressive symptoms prior to dementia diagnosis will also be examined.. "