frontpage.
newsnewestaskshowjobs

Open Source @Github

fp.

Show HN: Polyvia – Multimodal document retrieval over 100K+ files

https://github.com/polyvia-ai/polyvia
1•mgierlach-polyv•36s ago•0 comments

Show HN: Eggspression – shape any bird egg in 3D from four parameters

https://s13k.dev/eggspression/
1•s13k•1m ago•0 comments

Cotect – move around your repo with WASD

https://cotect.dev/
1•grzracz•6m ago•0 comments

World’s “most famous” tree dies after 1000 years in England

https://www.dexerto.com/entertainment/worlds-most-famous-tree-dies-after-1000-years-in-england-33...
1•thunderbong•7m ago•0 comments

Thomas Jefferson to John Norvell (1807)

https://press-pubs.uchicago.edu/founders/documents/amendI_speechs29.html
1•downbad_•8m ago•0 comments

Life: Nasty, Brutish, and Short (1987)

https://www.jsoftware.com/papers/eem/life.htm
2•tosh•10m ago•0 comments

Systems Get Gamed

https://arnoldkling.substack.com/p/systems-get-gamed
2•jger15•14m ago•0 comments

I found 10k GitHub repositories distributing Trojan malware

https://orchidfiles.com/github-repositories-distributing-malware/
3•theorchid•15m ago•0 comments

We blamed 112,000 commits to find out If AI-written code is buggier

https://www.repowise.dev/blog/engineering/is-ai-written-code-buggier-than-human-code
2•swatiahuja•15m ago•1 comments

AI will create more jobs for humans, not replace them says Jeff Bezos

https://www.bbc.co.uk/news/articles/ceqdrw2yy3vo
1•rvz•16m ago•1 comments

Adding a Town Square

https://kevquirk.com/town-square
2•whilenot-dev•18m ago•0 comments

Modos Color Monitor Pushes E-Paper Displays Further

https://spectrum.ieee.org/modos-e-paper-monitor
2•Vinnl•19m ago•1 comments

Prediction Markets' Next Major Bet: Wall St. Traders

https://www.nytimes.com/2026/06/17/business/dealbook/hedging-prediction-markets-kalshi.html
2•thm•19m ago•0 comments

Commodore's New Flip Phone Focuses on Digital Detox

https://www.cnet.com/tech/mobile/commodores-new-flip-phone-focuses-on-digital-detox-blocks-social...
1•daniel_iversen•20m ago•1 comments

We Did the Math on Why the iPhone 18 Pro Could Cost $1,299

https://www.wsj.com/tech/personal-tech/apple-iphone-price-increase-e846d737
1•thm•21m ago•0 comments

Rue: Higher level than Rust but lower level than Go

https://github.com/rue-language/rue
1•tosh•23m ago•0 comments

Challenging the Narrative of European Decline

https://paulkrugman.substack.com/p/challenging-the-narrative-of-european-478
8•vrganj•26m ago•0 comments

Prompt processing vs. generation: two phases, opposite bottlenecks

https://vettedconsumer.com/prompt-processing-vs-generation-why-your-box-is-fast-at-one-and-slow-a...
1•ermantrout•27m ago•0 comments

Trump says Apple to partner with Intel on US chip design, production

https://www.reuters.com/business/trump-says-apple-work-with-intel-manufacture-chips-us-2026-06-18/
1•maxloh•27m ago•0 comments

Designing delightful front ends with GPT-5.4

https://developers.openai.com/blog/designing-delightful-frontends-with-gpt-5-4
1•tosh•29m ago•1 comments

Towards Conversational AI for Disease Management

https://www.nature.com/articles/s41586-026-10764-5
2•hdvr•29m ago•0 comments

Syntaqlite 0.6: SQLite dot commands and pyodide

https://lalitm.com/post/syntaqlite-06/
1•nsm•30m ago•0 comments

Towards autonomous medical artificial intelligence agents

https://www.nature.com/articles/s41586-026-10675-5
1•hdvr•30m ago•0 comments

The Black Death and How It Birthed Today's Prosperity

https://www.opensourceceo.com/p/black-plague
3•qw•31m ago•0 comments

Ultrasound enables espresso-strength coffee brewing in 2–3 minutes at low temp

https://www.sciencedirect.com/science/article/pii/S0260877426002311
2•arnejenssen•32m ago•1 comments

Ask HN: Does taste matter when writting code

2•rafaepta•33m ago•2 comments

Claude Design now stays on brand for daily work

https://claude.com/blog/claude-design-stays-on-brand-for-daily-work
1•peterspath•37m ago•0 comments

SlopTacker: The AI Streaming Drain

https://sloptracker.org
2•rot256•38m ago•0 comments

The personal life of Charlemagne, the first Holy Roman Emperor

https://www.nationalgeographic.com/history/article/charlemagne-ancient-roman-empire
2•bookofjoe•38m ago•0 comments

I tried making a UI library

https://btmc.substack.com/p/i-tried-making-a-ui-library
1•sirwhinesalot•39m ago•0 comments
Open in hackernews

Hospitals and universities repurposing drugs at 90% lower cost

https://www.kcl.ac.uk/news/hospitals-and-universities-repurposing-drugs-at-90-lower-cost
42•giuliomagnifico•1h ago

Comments

turtleyacht•1h ago
How do people needing (and willing to risk) treatment hear about repurposing studies?
giuliomagnifico•1h ago
I think in the same way they participate in other clinical trials.
astura•47m ago
Big medical systems will post their clinical trails quarterly or so. If you have a big medical system near you you can sign up for emails. I imagine universities would have a mailing list too, if they regularly did clinical trials.

You can also search here: https://clinicaltrials.gov/

I was a clinical trial participant once and it was a positive experience for me.

oezi•1h ago
Such studies are great but there is no regulatory pathway to extend the use of existing drugs for new indications of use without the consent of the manufacturer (or becoming a manufacturer yourself).

This means such studies can give more clarity on which off-label use is beneficial but it can't be an officially allowed usage.

boxed•1h ago
That seems wild. Do you have a citation to back that up? And in what country/countries?
ktallett•1h ago
This isn't completely true at least in the UK. It is simply that the manufacturer is no longer responsible legally. The GMC allow prescibing of unlicensed meds. However the change needs to be made to the pathway. So many issues in the NHS has been due to pathway problems.
jawns•16m ago
I have been a supporter of Cures Within Reach, a nonprofit that focuses on repurposing drugs, especially for rare diseases. https://www.cureswithinreach.org

They have funded some important repurposed-drug studies for Huntingtons Disease, which runs in my family. For a disease like this, it's never going to make sense for major pharmaceutical companies to invest the effort to develop entirely new drugs, but by repurposing existing drugs, it gives people living with rare diseases a chance to ease symptoms.

ck2•14m ago
the thing is while something is better than nothing, new drug development is critical

there is absolutely no cure for certain types of long-covid and me-cfs right now

no repurposing any drug is going to cure it, they've tried everything after six years

it will take a decade to have anything even in the pipeline and won't emerge from the USA because all medical and science research investment by the government has been destroyed by Russell Vought and Heritage Foundation

JAK-STAT inhibitors will be a big treatment, not a cure, but they cost thousands per month in the USA because generics aren't allowed

xenophenes•7m ago
fascinating! I'm sure there's quite a bit that can be learned through appropriate research - pathways to solve problems that haven't been thought of before