Biggest changes in the new guidelines from the American Heart Association / American College of Cardiology:

  - Universal Lp(a) testing recommended for everyone - Lp(a) is the strongest hereditary risk factor for heart disease.
 -  Risk Equations switched to PREVENT, which predicts both 10-year and 30-year risk.
  - Treatment is now recommended for younger adults, based on these 30-year risk scores.
  - CAC scans recommended in more cases (for intermediate risk).
  - Specific LDL targets are back, after being removed in the 2013 guideline

The actual guidelines are long and make 52 distinct recommendations, but these are the ones that jumped out as the biggest new changes.