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For First Time, a Cell Built from Scratch Grows and Divides

https://www.quantamagazine.org/for-the-first-time-a-cell-built-from-scratch-grows-and-divides-20260701/
66•defrost•1h ago

Comments

bensyverson•37m ago
> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work.

That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can imagine?

TSiege•26m ago
I'm not a biologist so I can't say for sure, but it seems like it would be a lot easier to edit an existing living organism to produce those products than it would be to create completely from scratch. We already do this with the process known as precision fermentation. We've gotten very good at editing genomes via CRISPR and related techniques and are only getting better

https://en.wikipedia.org/wiki/Precision_fermentation

colordrops•19m ago
It seems that eventually you could build much more flexible and powerful if you build from scratch. Hacking existing cells is a shortcut but longer term we may get grey goo.
PaulHoule•11m ago
It's desirable to have some kind of simple base to start from that is an easy-to-configure platform to deploy any kind of metabolic machinery.

Their "minimal" cell is not quite a minimum product because it depends on prebuilt ribosomes and can't reproduce on it's own. No danger of gray goo!

This is more like it

https://www.jcvi.org/research/first-minimal-synthetic-bacter...

but those guys could probably add components to their cell to make it truly self-supporting although in biology there is a big difference between "barely works" and "high performance"

arjie•18m ago
Yes, mechanically constructing life would be absolutely stupendous for science. The real tragedy of modern sci-fi is that everyone read the books and decided it was reality.

“Penicillin?! A poison from fungus that kills living cells?! Haven’t you played the sci fi game The Last of Us?”

Stories are stories, man. Story-logic is biased towards interesting tales. And “discovery from the natural world turned to human aims with great results” is uninteresting because we do amazing things these days.

adrian_b•14m ago
While this is an impressive step forward, there remains an extremely long way, probably of several decades, until being able to design and synthesize a cell comparable in complexity with a bacterium.

The thing that they made is more alive than a crystal, which when placed in a suitable solution will grow and reproduce its own structure, but much less alive than even the simplest known living cells.

Its "life" is similar to that of a brain-dead human, whose body is not left to die by a bunch of machines that pump air into its lungs and nutrients through its blood vessels.

The techniques developed to make this pseudo-cell might evolve eventually into techniques able to make a true cell and it is likely that valuable information can be extracted from experiments with it, but it is very unlikely that any of the ancestors of the living beings has ever had even a remote resemblance with this.

Some components of this thing are growing by reproducing themselves, but like I have said, so does any crystal, thus it is difficult to choose a criterion that will distinguish with certainty what is living from what is non-living.

The growth is followed by a kind of division into 2 vesicles, but that happens by a mechanism very different from any living cell. Many inorganic things will split when growing over a certain size, so again it is hard to decide whether this can be called living.

JumpCrisscross•10m ago
> That is the holy grail?

If you can disassemble and reassemble a thing, you can say you understand it. Not perfectly. But understand it. I’d imagine properly understanding rudimentary cellular biology will come with perks.

(Also, does the Holy Grail imply both a boon and a cost? Or is that just Indian Jones.)

fouc•9m ago
[delayed]
Legend2440•7m ago
Man, I am so tired of the cynicism around here.

Anytime you do something interesting or useful someone accuses you of trying to build the apocalypse.

burnte•35m ago
Interesting that this is led by the same Dr. Kate Adamala who ended the right-handed-proteins experiment a couple of years ago. Given how close she was I'm not surprised she's made this work.
small_model•23m ago
The aliens that seeded life on Earth are seeing us making baby steps. Expect a visit soon!
JumpCrisscross•12m ago
> aliens that seeded life on Earth are seeing us making baby steps

Or like a grad student didn’t dispose of their work properly and are desperately trying to distract from their scandal.

JumpCrisscross•20m ago
“This was where the field had been stuck for some time. Researchers before Adamala had figured out different ways to feed and grow synthetic cells and to replicate their DNA. But cell division is a different beast. A typical cell reorganizes its cytoskeleton — a network of protein fibers that provide structural support — to halve its DNA and split. Synthetic biologists could not figure out how to get their cells to undergo this complex process.

So Adamala decided to ditch the cytoskeleton. One day, while tearing through the literature, she came across an interesting mechanism in a paper (opens a new tab). By attaching protein tags to a cell membrane, the synthetic biologist Reinhard Lipowsky (opens a new tab) at the Max Planck Institute of Colloids and Interfaces attracted other proteins to crowd around and physically bend the membrane, forcing the cell to divide. Following this approach, Adamala tweaked a cell-membrane protein and tested it in her protocells. After several tries, it worked.“

This is the novel bit.

mghackerlady•16m ago
I wonder if these principles could be applied to non-organic components. I imagine a completely synthetic robo-cell would raise interesting questions.

Also, go MN!

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