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Bryan Johnson: I have an autoimmune disease. My stomach is eating itself

https://twitter.com/bryan_johnson/status/2072069730517860385
31•danso•1h ago

Comments

danso•1h ago
First part of the very long tweet:

Bad news #1:

I have an autoimmune disease. My stomach is eating itself.

Bad news #2:

2–5% of people have this, too. Likely more, because it hides.

Good news:

I'm going to try and solve it. Will share all.

As a kid, I ate sugar cereal, drank sugary soda, and gobbled down fast food. I had a few healthy years in my early 20s but then became a young father of three and began building a business.

Juggling that stress and grind, I let my health slip and gained 40 lbs. Within a few years I’d fallen into a deep, chronic depression.

Somewhere in that timeline, my body began developing an autoimmune process affecting my thyroid and then my stomach lining.

It’s called Autoimmune Gastritis (AIG).

My hypothyroidism got diagnosed when I was 21 years old with a routine blood draw. That enabled me to begin proactive management, supplementing levothyroxine and Armour Thyroid. They are the hormones my body should be producing on its own but wasn’t.

By taking these pills daily, my body was able to operate as though my thyroid was functioning properly. What I didn’t know was that something else was going on inside my body: my stomach had begun attacking itself. But there was no routine test to find out and I didn’t have any symptoms.

I just discovered it in May. I'm unsure how long I've had it. AIG causes irreversible damage: nutritional deficiency, anemia, and over a long horizon, elevated cancer risk. When AIG is discovered today, standard medical care concedes defeat, stating that nothing can be done except managing the condition, no matter how awful or lethal the effects.

Looking back over the past few years, I can now see the early signals we were picking up in measurement but hadn’t connected the dots. For 11 years, I’ve had low ferritin, without anemia. We continually tried to raise my iron levels with food and supplementation but nothing would work.

We chased the obvious solutions first. A plant-based diet means all my iron is the hard-to-absorb, non-heme kind. Hard training, sauna, and hyperbaric oxygen all raise the body's demand for iron. But none of them explained the core failure: despite me taking iron orally, trialing every formulation, and using every timing trick, none of the iron would stick.

What I didn’t fully appreciate until recently is how many stones my previous providers had left unturned. The low ferritin kept getting explained away but not fixed.

Noaidi•21m ago
First, I could tell you this guy was going to fail, and he will continue to fail because he does not consider genetics in any of his treatments or ideas. We’re all genetically different and that’s gonna determine our diet and where our nutritional deficiencies might occur.

Next, I believe he most likely gave the gastritis to himself because there are many things that can give rise to autoimmune diseases including several medications. If medication can do this, jamming a ton of supplements down your throat can also do it.

Believe me, I’ve been bio hacking myself for the last 20 years as well, but I’m poor. And that’s what it’s probably saved me. But I’ve come to a place to know what I can know and know what I will never know. It’s a happy balance between being healthier but not under the delusion that I will live forever.

No granted I am in a much worse position to start than Brian Johnson. I am poor and I have a serious mental illness, but I think I’ve done way better than him although I am 60 now and the stress of being homeless and suffering under this great separation of wealth has made things harder. I don’t have the money to get rid of my stress so maybe if you’re out there Brian Johnson and you wanna talk, hit me up.

francisofascii•15m ago
Wonder if he has Hashimoto's, an autoimmune condition where the immune system attacks the thyroid, causing hypothyroidism. The hypothyroidism lowers stomach acid, impairing iron absorption. Sounds similar to what is being described.
an0malous•33m ago
https://xcancel.com/bryan_johnson/status/2072069730517860385
ck2•29m ago
my 2 cents

1. try taking Saccharomyces Boulardii asap, it is a very different kind of probiotic, a yeast actually, that tends to push out the bad and promote the good

2. JAK-STAT inhibitors are the only known drug to get the body to stop attacking itself from autoimmune diseases, but not a cure and unfortunately they cost an absolute fortune without insurance but importing from Canada and India is possible

4fterd4rk•28m ago
Chronic attention seeking weirdo discovers he has common condition, will now have to do iron and B12 supplementation. yawn
pingou•17m ago
Did he somehow wronged you or are you just having a bad day?
psygn89•10m ago
Guy is a weirdo, I remember logging into Twitter a few weeks ago and he was talking about his wife like she were some lab experiment. I don't know if it was a joke but it coming from a weirdo didn't help.
pingou•7m ago
Personally I am happy that there are weirdos and that they share their weirdness.

What he has may not be a very serious disease yet I was interested in learning about his experience and felt sorry for him.

sgt101•24m ago
I know many will draw a line between Hubris and Nemesis here, but I feel really sorry for this guy and just wish some good health for him. I personally find the whole long life influncing and health hacking movement annoying, but I recognise that many, if not most, of the folks involved are acting in good faith and just trying to feel better themselves or help others feel better.

He probably can't any more (I have no idea what the implications of his stomach disorder are, but I don't imagine great). But if he can I hope he has a beer and just relaxes and gets some happy vibes for a time.

figmert•20m ago
> I'm going to try and solve it. Will share all.

Will he share all or will he try to sell you some fad instead? I wish him the best, and hope he recovers, but my money is on him trying to sell something new that won't work.

catigula•18m ago
His protocols are usually pretty robustly researched. The worst thing you can say about Bryan Johnson is that I personally believe he over-indexes on suspect science, but that's it.
wouldbecouldbe•17m ago
His longevity protocol trial with group of people had negative overall results according to ny times. His supplements tested to not contain what it claimed

https://www.nytimes.com/2025/03/21/technology/bryan-johnson-...

catigula•3m ago
Thanks; I read the story you linked. It mostly reads as a hit piece centered around various legal allegations tied to stringent confidentiality agreements. There isn't much substance beyond that. The article briefly discusses some vague customer complaints about allulose-directed side-effects from his 'longevity mix', but the actual complaints are incredibly vague and you could attribute side-effects to or from basically any supplement. The article is basically a long-form screed saying over and over "he makes you sign confidentiality agreements".

I don't like Bryan Johnson per se, I just don't think that mal-intent has been substantiated.

Yapping7880•16m ago
I really appreciate how the author dramatizes hypothyroidism, which I've also had since 25, and in the modern world, it's like the most treatable, easy to live with condition on earth. Taking a tiny pill once daily, with the lone drawback that as soon as you take the pill you have a 5min timer to taking a dump.

I was reading this and didn't understand the point until I got to this:

"I overhauled my medical team earlier this year. It was the rebuild to lay the groundwork for Immortals Care, our $1M a year protocol. With greater capacity, we revisited everything."

And realized this person is speaking the language of scams.

WarmWash•2m ago
Ehhh, not really, I have been loosely following him for a while and he is overall pretty genuine (i.e. laser focused on his health experiment above all else)

He was the founder of Braintree which sold to paypal for $800M. He then was divorced and listless with near infinite money, so decided to see what would happen if money was no object and you tried to live a perfectly healthy life as dictated by current medical research, and document it.

He does sell supplements and now whatever immortals care is, but I can't imagine he makes much money from either compared to his NW. It's more likely that there is demand from people following his experiment to get in on his findings, because again, he doesn't have much incentive to scam people and his goal is already a selfish one, to "not die".

iammjm•10m ago
It's kinda disgusting how many people seem to enjoy his misfortune. Even though he never hurt anyone and has been an overall positive, if peculiar, person. I hope he recovers or at least contains this and continues with his mission
slifin•3m ago
I wouldn't be surprised if it's the glyphosate

We need to get back to regenerative farming that already has time proven solutions for weeds (ok maybe not the same yield straight away but at least its sustainable)

If your soil is just a chemical laden dust bowl then there are 2nd and 3 order effects from that

eth0up•2m ago
To those suffering similar issues: don't give up. There are many off label options to pursue. Immuno-modulation is, from my observations, understudied. I won't list anything here though.

Also, we're continuously finding new roles that microbes play in autoimmune disorders, eg rheumatoid, a condition which I myself have managed to reverse from utterly disabling to perfectly functional. My rheumatoid was almost certainly triggered by microbial (bacterial/viral) activity.

H Pylori is ubiquitous, and quite transmissible. Medical journals describe the many ways it can transmit, even via flies landing on utensils, plates, etc. I do not suggest pylori is directly at work here, but the growing consensus when treating it is that reducing it, not eradicating it, may be the better approach. Considering the many ailments it might be contributing to, including some forms of cancer, protocols for managing it may be prudent. But pylori is one of many, and there are countless strains of it alone.

I got to the point where I would get rashes from touching certain materials. That persisted for over a year. Not presently though. Doctors literally mocked me though, and without the temptation of insurance to milk, would ave nothing to do with me, at times literally taunting me.

My last encounter with an ER doctor was due to nasal swelling and pain, accompanied by extreme fatigue and malaise. During the visit, he told me to simply use any sharp object to remove the internal swollen matter and consider taking antidepressants. As soon as he left the room, so did I, and promptly the hospital itself. Unconventional disorders can seem futile, but there are, until corporately aligned LLMs central information and substitute the internet altogether, many medical journals, case reports and research papers remain available.

I had chronic high BP sitting often around 197/170. Doctors told me I'd need to remain on BP medicine indefinitely, and that it would almost certainly be irreversible. When I could no longer afford regular tests, my GP sent a certified letter dismissing me as a patient. That was the end of my BP meds. 4 years later, without any medication, my BP sits at ~128/87, which may not be ideal, but is better than it was while on the meds.

I will say, that if we can wangle a truly FOSS LLM, rigorously policed for corporate and institutional influence, a lot of what is presently ailing us could be resolved. Many answer are out there, many waiting to be conceptually synthesized, but there is a lot out there. And there is a lot incentive going in both directions.

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