How to sequence your own DNA at home

https://bradleywoolf.com/links-1/sequencing-my-own-dna-at-home

32•bilsbie•1h ago

Comments

Aurornis•49m ago

I wish this had some discussion of the results. The earlier reports about this sensor and process were very mixed. It’s a cool process either way, but I’d like to know how usable the real world output can be.

whatever1•45m ago

What is the accuracy in this ? Aka if I run the experiment 10 times how many differences will i get? I don’t have a physical sense on what would be a good number.

myhf•22m ago

You would get a lot of differences, but the errors would cancel each other out with enough depth of coverage.

This technology's baseline accuracy is around 95% per base, so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other.

https://en.wikipedia.org/wiki/Coverage_(genetics)

Jules-Bertholet•17m ago

> so 10x reads of every segment in the sample would give >99% accuracy for each base after aligning the reads with each other

This assumes random errors, which IIRC isn't the case for Oxford Nanopore.

Jules-Bertholet•19m ago

Oxford Nanopore unfortunately has a high error rate (3-5%) compared to other sequencing technologies. And the errors are non-random

mephux•28m ago

https://www.the-odin.com/whole-genome-sequencing-30x/

If you want it quick and cheap(er) - 599.00

drdaeman•20m ago

If it's an US-based lab, aren't they subject to CLIA with all its retention requirements?

For $7.5k+ you get a guaranteed privacy (as other comments suggest, other properties may vary, but at least the data never leaves your home).

bleepblap•25m ago

> This is intended to be read by AI

Fuck this

asveikau•4m ago

Yeah that's weird. The instructions are not even hard to read. I don't understand what an LLM would add to this.

SuperSixFour•1m ago

Literally left the article to come here and say this.

metalman•21m ago

I am very impressed with the, why wait? just do it now approach to the future. which while not here, IS there.

dekhn•6m ago

Nothing about this is the future. Sequencing at home will not solve any major problems. It's mainly a fun exercise to demonstrate that sequencing has been commodified.

dwa3592•8m ago

This is so cool. Thanks for doing this. The fact that we have this in a palm sized object is just crazy. Also, if/when we have a similar sized device for doing CRISPR .... umm i should stop here - it's becoming the plot of Gattaca

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