He was, arguably, the US politician most consequential in getting the USA into the Iran conflict, and Trump may have resented that, recently. But I don’t think it changes much on the Iran front, considering that is largely driven by the incompetence of Vance, Kushner and Witkoff; it’s a quagmire with or without Graham and I am not convinced Trump is particularly engaged. It does mean one less interlocutor for Netanyahu.

He was Ukraine’s most constant supporter and Russia’s most consistent critic in Trump’s orbit, and given the very notable way Trump tends to be influenced by the last person he talked to, there may be implications with him no longer being around to Trump-whisper. Especially since Rubio is so distracted.

Not sure things change much in the Senate regarding Graham, but the impact on what conversations Trump has on a daily basis is much bigger.

If McConnell were to be replaced, that would shift the balance, which is why Republicans and their proxies are all engaged in pretending he remains competent to try to run out the clock.