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4•Bender•15m ago•0 comments

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Ukrainian drones deliver robots directly into battle by sea and air

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2•arto•17m ago•0 comments

International flights set to pay EU carbon fees from 2029

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3•Markoff•18m ago•2 comments

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2•xdavidliu•18m ago•0 comments

Agent-Native Software Engineering

https://sys0.substack.com/p/agent-native-software-engineering
2•shenli3514•20m ago•0 comments

I built a platform that tracks which software people cancel and regret"

https://www.gotypical.com
2•Gotyypical•20m ago•0 comments
Open in hackernews

Does creatine make you smarter?

https://dynomight.net/creatine/
101•surprisetalk•55m ago

Comments

petra•46m ago
Given LLM's is being smarter still a worthwhile to optimize with supplements?
fragmede•42m ago
that was hard to parse, but yes, because then you can ask smarter questions to the LLM which saves you money, so you can afford supplements
isakmarr•17m ago
Of course it is. LLMs aren't as smart as you think, or at least their "intelligence" isn't comparable to ours. They're just a useful tool, and they will always need someone to guide them.
binary132•14m ago
Productivity isn’t the only reason to be smarter. For example, there’s also the benefit of asking fewer inane questions on the internet (hypothetically)
petra•8m ago
LoL.maybe the question is not phrased in the best way, English as a second language and laziness, but it's a pretty decent question.
shermantanktop•6m ago
Present company excluded, of course.
brcmthrowaway•43m ago
I remember learning about Creatine as a weightlifting teen

I never ended up doing it because you had to cycle it, and it was just one more thing to track

Is it the same case in 2026? Is there a simple pill I can take?

domhudson•42m ago
You don't have to cycle it. You also don't need to load it (a marketing ploy to get you to buy more).

You can just take 3-5g daily.

windward•27m ago
Cycling is also a marketing ploy, since it makes it sound more like a PED and less like a compound found naturally in meat. It's the same reason people say they 'take' whey, when Miss Muffet simply ate it.
btheconqueror•40m ago
I've never heard of cycling it. We're you a teen during the steroid arrival? Maybe people were confusing things. I've always just done 5mg a day, but now people are talking about taking mega doses of like 20-30mg a day, shrug
nick__m•34m ago
Creatine is dosed in grams not milligrams, otherwise your number are correct.
jdelfuego•6m ago
Homeopathic sports supplementation
dvduval•41m ago
I don’t think they’re strong evidence that it does anything beyond helping you build muscle. There are some people say they think clearer, but I don’t think that’s been measured in any significant way.
garciasn•38m ago
Saved you a click:

> Does creatine make you smarter?

> I don’t know. Maybe a little.

olooney•38m ago
Good discussion, but this conclusion:

> I don’t know. Maybe a little.

is not the right way to interpret the null result (insufficient evidence to reject null hypothesis that it has no effect) because the prior for supplements that people are trying to sell you is so low. In the absence of clear, strong evidence, you should assume the the whole thing is just an example of motivated reasoning. People want nootropics to be real, and other people really want to sell you readily available powders by claiming they have nootropic properties. In that environment, they were always going to trying to concoct a similar narrative about some supplement, and it just happened to be creatine. Those efforts were always going to result in a handful of "positive" studies that turn out to be non-reproducible, maybe because of p-hacking, maybe because of publication bias, maybe because of outright fraud. This is what the literature always looks like for stuff that just doesn't work. If it did work - if the effect size was large enough that you could personally detect it in your own life - then the papers would be trying to put error bars around the effect size, not trying (and failing) to barely distinguish it from a placebo.

“If your experiment needs statistics, you ought to have done a better experiment.” - Ernest Rutherford

taeric•34m ago
Heavily agreed. The supplement industry has such a low level of reliability that it has really soured me on so many practices people have. And I flat out do not understand how some of the supplement stores survive.
PaulHoule•24m ago
Hard sell. I remember the time I went to GNC and they gave me a free sample of the notorious Jack3D which had some kind of amphetamine-like stimulant in it and was associated with young soldiers in the US Army falling down dead.
Johnny555•7m ago
aeonik•38m ago
Studies I read seems to show a marginal boost in cognitionl and memory, but only if you were otherwise overtaxed for some reason.

Like being tired, stressed, etc...

slipnslider•21m ago
Yep. From what I read mental fatigue (mental math problems is what the study used) or sleep deprivation are two scenarios in which creatine boosted cognition and memory.

Here are the sleep deprivation studies

https://www.nature.com/articles/s41598-024-54249-9

https://pubmed.ncbi.nlm.nih.gov/16416332/

softbuilder•36m ago
I started taking 5g for cognition. Never any clear signal for that, but it does seem to help a bit with my (more than occasional) sleep deprivation. Mostly with fighting off headaches.
thisisauserid•36m ago
Article's answer to its own question:

It safely builds muscle and boosts cognition.

dd8601fn•29m ago
No, it does not.

More like "probably", "yes", and "probably not."

faangguyindia•34m ago
Sometimes I stay up until 1–3 a.m. because I'm working on a problem that's so interesting I can't stop until I make progress.

If I know I'm only going to get a few hours of sleep, I'll take 5–10 g of creatine, drink plenty of water, and go to bed. The next morning, I usually don't wake up with a headache.

If I skip the creatine under the same conditions, I'm much more likely to wake up with a headache after a short night's sleep.

Now it's become a habit, I automatically take creatine whenever I know my sleep duration is going to be much shorter than usual.

pawelduda•32m ago
Do you take monohydrate or HCL?
faangguyindia•22m ago
most common one, monohydrate.
BugsJustFindMe•31m ago
> If I know I'm only going to get a few hours of sleep, I'll ... drink plenty of water

https://my.clevelandclinic.org/health/diseases/21517-dehydra...

faangguyindia•22m ago
from your link

>Headache pain often appears along with other signs and symptoms of dehydration, including darker-than-usual pee, dry mouth and fatigue

none of these symptoms are true for me.

imzadi•34m ago
This made me wonder if sun exposure/vitamin D has any impact on storing or processing creatine, and maybe that's why the results in Australia were so much greater
bassiee•31m ago
In my experience, it wont make you smarter but my brain just feels more energized to think.
John23832•30m ago
Most people taking creatine just need to drink water. They drink more water using creatine. In reality, the water/hydration is doing the heaviest lift, not the creatine.
Retr0id•25m ago
I take my creatine with as little volume of water as possible, probably less than 50ml. I doubt that 50ml is having much impact on my overall hydration.
clayhacks•23m ago
How much water are you drinking the rest of the day? Creatine in theory makes you more thirsty such that you should be drinking more water throughout the day
Retr0id•22m ago
It's not something I track, but if it is making me thirstier then that sounds like another useful benefit.
berkeatac•20m ago
yes but again, the idea is that it helps retains water in your muscles so I don't see it aiding in regular water intake
John23832•23m ago
If you actually drank enough water daily, sans creatine, I'm sure you'd feel better.
6thbit•28m ago
Why is creatine so popular lately? what changed?
gedy•27m ago
Health fads come and go
throwup238•25m ago
It’s always been popular among athletes and weight lifters but now nootropic influencers have gotten ahold of it. It’s one of the few supplements with robust scientific evidence of a strong effect but that’s in athletic performance not nootropics.
exhumet•22m ago
another upside is its also hella cheap so its a very easy addin
matwood•5m ago
I've been taking 5g/creatine daily for nearly 30 years. In weightlifting circles it's always been popular because it's cheap and one of the few non-steroidal supplements that actually works.
igor_nast•26m ago
Nope, but makes a producer's pocket heavier :D
croes•12m ago
When you realize that, you got a little smarter
sspehr•24m ago
> Available short and long-term studies in healthy and diseased populations, from > infants to the elderly, at dosages ranging from 0.3 to 0.8 g/kg/day for up to 5 > years have consistently shown that creatine supplementation poses no adverse > health risks and may provide a number of health and performance benefits.

They missed a zero behind the comma, didn't they?

nonameiguess•22m ago
The conclusions aren't any different (it's one of the few thing that helps strength, poses no danger to your hair, and almost certainly does nothing for cognition), but the articles at https://www.strongerbyscience.com/?s=creatine are far more comprehensive, including the famous extremely long podcast episodes they used to do.

The one thing this misses is many supplements are tainted, which skews the popular perception of both upsides and risks. This was especially true in the US prior to 2005 or so when prohormones were still legal over the counter. Anything branded that wasn't just pure creatine was extremely likely to actually be a low-dose oral steroid, which really can make you lose hair and will increase strength quite a bit more than any dietary supplement.

This also misses caffeine as the other a-tier supplement that consistently shows strength increases in RCTs, though of course, caffeine is more frought than creatine because you build tolerance and it can disturb sleep.

switchbak•10m ago
"poses no danger to your hair" I keep hearing folks say this, and even in this thread there's someone who's experienced that and had it stop when they eliminated creatine. I too have experienced exactly that with exactly the stopping of issues once I stopped taking creatine.

Perhaps you can say "danger to your hair is rare", but there's very clearly (to me at least) an effect there, and the way it gets hand-waved away is strange to me.

matwood•7m ago
> This also misses caffeine as the other a-tier supplement

In college Ripped Fuel wasn't banned yet. We would take two, go to the gym for 2 hours, shower, then go out until the sun came up the next day. It's no surprise it was eventually banned. I think some people ended up dying by taking too many.

doix•19m ago
This matches what Gwern wrote years ago [0]. It does unequivocally make you stronger though. So if you're training anyway, may as well take it and hope it makes you smarter as well (just believing might be enough for that sweet placebo effect).

[0] https://gwern.net/creatine

serf•17m ago
>Contrary to the common myth, thinking hard does not burn significantly more calories. (Demonstration: Start thinking hard, and watch as your heart rate does not increase.)

this is wrong [0] , it's just hard to measure.

[0]: https://pubmed.ncbi.nlm.nih.gov/32314956/

Aurornis•8m ago
The original claim is not wrong. Thinking hard does not burn significantly more calories.

If it’s really hard to measure because the amount is so small that it requires precise equipment, it’s not significant relative to the rest of the body’s energy expenditure.

jfrbfbreudh•17m ago
Would also be interesting to study creatine’s effect on depression. There is some promising research and I personally (having used it and stopped using it at various points) have definitely noticed a difference.

Just having the desire to think makes a huge difference.

zuzululu•16m ago
if you are using to slim down it will hold on to water unless you are bulking i dont see creatine to be consumed regularly

if you truly want fuel for the brain nothing beats keto

blobbers•10m ago
Okay, I skimmed the article.

Is creatine safe to supplement for children?

MadameMinty•7m ago
> thinking hard does not burn significantly more calories

Up to 50 Cal extra over ~2 hours of intense thinking IS significant given brains consume 240-400 Cal over 24 hours.

> Start thinking hard, and watch as your heart rate does not increase.

And yet you soon get tired and slow down. Now try the opposite. Stretch or punch the air a few times to get the heart rate going. You'll sustain brain performance for longer. Try it.

Perhaps the problem is that higher brain activity SHOULD trigger heart rate increase, but doesn't due to one of many design defects of the human body.

131012•5m ago
I think another source of variation on the results is the actual nutritional intake of the subjects.

The vegan/vegetarian is a big spectrum. A vegetarian eating plenty of dairy products and eggs should in theory be much better creatine-equipped than a poor student feeding on ramen and ketchup pastas. A lot of pseudo-meat for vegans are full of processed shit.

Confusion will be even higher if you include fish in the vegetarian diet, which is odd but some people do that.

Could the cognitive effect works in the case of creatine deficiency (vegan) and not in the case a vegetarian (low creatine but not deficient) ?

solumunus•39m ago
That’s never been the case, you were getting bad information.
switchbak•9m ago
It was certainly the case that gym bros thought you had to cycle it. But you're right that this was never necessary.
krick•28m ago
Yes, they did, and many still do write it on the package, but it is, and always was a myth born God knows when out of precaution, because nobody really knows anything about how all this stuff really works now, and they did know even less than that 30 years ago. There never really was any evidence that you have to cycle it, and nobody (aside from the manufacturers) ever says it anymore. It makes about as much sense as cycling protein powder.

As for pills, yes, there is about every form of creatine supplement now, even chewing gum, but this is just dumb, how much of creatine do you think you can consume this way in a day?

matwood•11m ago
Cycling creatine was the guidance from the 90s. 5g/day and drink plenty of water is all you need to do.
>And I flat out do not understand how some of the supplement stores survive.

I think mostly through placebo effect, people buy a supplement to treat condition X and they think it's getting better, so they keep buying.

I mean, just look at the wide variety of homeopathic "cures" that are often so diluted that there might not be any molecules of the active ingredient left. Yet people keep buying it.

jrm4•30m ago
Okay, but it kind of sounds like you want to nanny-state the writer's language.

Their conclusion seems like an absolutely fair interpretation of what they saw, and it also strikes me as dangerous -- perhaps more dangerous -- to suggest "writer genuinely believes, or doesn't believe, a thing, but they should say it differently from their own interpretation because..people are dumb?" Something like that.

jdiff•14m ago
One person is not a nation.
Retr0id•29m ago
If you're being academically rigorous about it, sure, but I think it's fine as an informal conclusion.
jdiff•20m ago
Even as an informal conclusion I think it's important to know who you're up against and what their motivations are. Waving that away is how we get people like known, obvious charlatans like RFK Jr in any sort of position of power. I know this is nitpicking word choice but the informal conclusion is "Not likely, and not enough to matter for anything."
Retr0id•15m ago
Personally I take creatine for entirely non-cognitive reasons, so it's reassuring to know it's probably not making me any dumber.
NopIdoN•8m ago
it might even be counteracting the negative effects of your frequent contact with airborne nitrogen
ttul•14m ago
What value is there to an informal conclusion when the topic is as important as intelligence? The downsides to creatine if taken without good scientific backing should not be disregarded, yet that’s exactly what many ordinary people are now doing because of “informal conclusions” like this.
overgard•12m ago
Are there really downsides to creatine though? (Genuine question). All the advice I've seen makes it seem like it's basically just good for you even if it doesn't accomplish some specific thing. The only downside I've heard is maybe water retention?
freehorse•11m ago
What are the "downsides"? It is one of the most studied substances and except in special cases like kidney issues it is totally safe.
abirch•12m ago
mandatory XKCD https://xkcd.com/882/ "Jellybeans cause acne"
BugsJustFindMe•19m ago
"often" and "always" are two different words that mean two different things
faangguyindia•14m ago
Yes, but hydration isn’t really a problem for me. I’m a bit of a water purification nerd, I collect water from a natural waterfall, run it through multiple stages of purification, and then start convincing myself it has some magical properties. I don’t drink soda or caffeine, I mostly just drink water.
johnthedebs•29m ago
Do you still drink water when you skip creatine? Being dehydrated causes headaches, so it may be the extra water intake that's helping and not the creatine.
faangguyindia•24m ago
yes, i always drink plenty of water throughout day and night too, infact when i get stuck on a problem i go for a walk and drink water.

So drinking water part is consistent with or without creatine. I do know the creatine takes a while to build up, so i don't know why it works but it does.

Retr0id
•
19m ago
Hydration is important so I'm with you on the first half, but what is the proposed link between reduced creatine intake and emotional wellbeing?
John23832•17m ago
Placebo.
Retr0id•14m ago
I wasn't expecting creatine to have any bearing on my emotional state in the first place, so I'm not sure how that would work.
Isamu•23m ago
A pity that water isn’t being sold as an expensive supplement. Or is it?
geophile•22m ago
You're looking in the wrong place. There is a moderately large industry around water bottles.
jerlam•19m ago
There are lots like Vitamin water, alkaline, and coconut water. And overpriced salt packets like Nuun and LMNT.

There's also no shortage of expensive water bottles being sold, and smart water bottles that track your drinking frequencies and flavor pods sold via subscription.

TIPSIO•23m ago
I don’t know. I personally wouldn’t take it if you aren’t also working out/lifting frequently (even if you drink a ton of water).

Anecdotal so safe to ignore this… but my hair did thin out but only after I was lazier on my work outs. Stopped taking and hair mostly returned to normal thank God.

leoqa•20m ago
I get severe muscle cramping, even after pounding water and electrolytes. Like I can’t handle my kid something in the car without risking a spasm.
logicallee•16m ago
spasms are commonly a potassium deficiency, you could take a multivitamin.
parpfish•15m ago
I like creatine when I’m lifting because it reduces soreness. For some people that effect helps them push further and train harder, for me it’s just proactive pain relief
jgbuddy•14m ago
This is not true
peder•7m ago
People love to float this myth that everyone's just walking around dehydrated all the time and they do so based on absolutely no data.
jacob_rezi•12m ago
just reminded me to buy a decent waterbottle - thank you
richardlblair•6m ago
I slam a lot of water. I also have a toddler and baby who suck at sleeping (I've done all the things, these kids just suck at sleeping).

Since taking creatine I feel so much more energized. I can make it through the day with just 2 coffees (was previously drinking 5 coffees and an energy drink).

Maybe it's placebo. Maybe it's not. I don't really care. I feel the benefit and I love it.