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Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

https://twitter.com/NoubarAfeyan/status/2090050162441752787
32•heydenberk•41m ago

Comments

GenerWork•16m ago
This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.
epistasis•15m ago
Ever since I first heard of them a decade ago, it seemed that mRNA therapeutic vaccines were going to be the next wave of massive improvements in care. It's taken a bit longer than I had expected, and it's not that mRNA is the only way to make these sorts of vaccines, it's just so much better than the alternatives.

I'm very very excited to see what comes next.

consumer451•5m ago
This appears to be a huge potential win for health. The market has Merck up 95%, which is some sort of validation I suppose.

Related stories:

https://www.fiercebiotech.com/biotech/merck-and-modernas-per...

https://www.reuters.com/legal/litigation/merck-moderna-say-m...

https://www.wsj.com/health/pharma/moderna-merck-vaccine-succ...

MartinMond•5m ago
I listened to a great podcast on this just a month ago - too bad that I thought all of this would obviously be priced in already… https://virological.podigee.io/51-21-cancer-vaccines-how-the...

We Bought a $500 Counterfeit Rolex So Good, Even Rolex Didn't Spot It

https://www.wired.com/story/we-bought-a-counterfeit-rolex-so-good-even-rolex-didnt-spot-it/
1•Brajeshwar•4m ago•0 comments

Google Just Made It Easier for Campaigns to Send You Fund-Raising Emails

https://www.nytimes.com/2026/08/18/us/politics/google-political-campaigns-email-spam.html
1•reaperducer•5m ago•0 comments

Windows Defender Crashes During a Quick Scan

https://borncity.com/win/2026/08/19/windows-defender-crashes-during-a-quick-scan-august-18-2026/
1•speckx•5m ago•0 comments

Show HN: Infinitely nestable visual task organizer and workload simulator

https://projectzen.com/home
2•dbullist•6m ago•0 comments

The Martians (Scientists)

https://en.wikipedia.org/wiki/The_Martians_(scientists)
1•leonidasrup•7m ago•0 comments

Getting set up on local AI. Here's what matters

https://twitter.com/draginol/status/2089338779324543047
2•draginol•7m ago•0 comments

Show HN: Goldset, 896 Python bug fixes verified by running the tests

https://github.com/andysalvo/goldset
1•andysalvo1•7m ago•0 comments

DIY Digital Photo Frame with RPI, Immich, and an old monitor

https://www.reddit.com/r/immich/comments/1vpujpo/new_raspberry_pi_digital_photo_frame_with_immich/
1•henriquenunez•8m ago•0 comments

HiFi Speaker Size/Spec Comparisons

http://www.truescaleaudio.com
1•Nagu-TSAudio•8m ago•1 comments

Code Is Not the Outcome, Learning Is

https://pawelbrodzinski.substack.com/p/code-is-not-the-outcome-learning
2•flail•8m ago•0 comments

It took us 9 years, 11 prototypes, and our life savings

https://twitter.com/mehul/status/2089784603737575470
1•tosh•9m ago•0 comments

The Sleepless Ape

https://claude.ai/code/artifact/bbf59276-21bf-4f0d-9e53-93bd9b7c526a
1•shafkathullah•9m ago•0 comments

Show HN: Remove logo from any t-shirt

https://www.removelogofromphotos.com/
1•StanleySathler•11m ago•0 comments

Show HN: Sequo – Writes your plan and decisions into files your agent reads

https://sequo.app
1•shken•11m ago•0 comments

I'm so f-n tired of the Internet It has become the worst place

2•behindai•12m ago•1 comments

On the fly, image transformation and delivery pipeline

https://github.com/go-batteries/optimux
1•argentum47•12m ago•0 comments

Show HN: NextBlock CMS – open-source fullstack CMS for NextJS 16 and Supabase

https://nextblock.dev
1•nextblock•13m ago•0 comments

Show HN: Verify OpenAI's signed agent traffic in Python (RFC 9421/Web Bot Auth)

https://github.com/regent-protocol/regent-httpsig
2•abay_aubakirov•13m ago•0 comments

PWA: Personal Web Apps

https://ma.ttias.be/pwas-personal-web-apps/
1•Mojah•13m ago•0 comments

I'll Follow the Sun

https://leancrew.com/all-this/2026/08/ill-follow-the-sun/
2•surprisetalk•14m ago•0 comments

What Happened on Easter Island?

https://www.scientificamerican.com/article/what-really-happened-on-easter-island/
1•sohkamyung•14m ago•0 comments

How to Survive the AI Cyberpocalypse

https://www.derekthompson.org/p/how-to-survive-the-ai-cyberpocalypse
1•momentmaker•15m ago•0 comments

WireGuard VPN Troubleshooting for Linux Administrators

https://barelypatched.com/wireguard-vpn-troubleshooting-for-linux-administrators/
1•whatbackup•16m ago•0 comments

A filename when none exists

https://daniel.haxx.se/blog/2024/08/19/a-filename-when-none-exists/
1•birdculture•16m ago•0 comments

South Korea youth employment falls sharply in AI-exposed industries, BOK says

https://www.koreajoongangdaily.com/business/94-of-job-losses-among-young-people-over-past-4-years...
1•neom•18m ago•0 comments

Reducing my blog's cloud costs to $0

https://flowtwo.io/post/building-a-new-blog-pt.-3
2•thejoeflow•18m ago•0 comments

Why I'm Staying Out of the Substack Religion Debate

https://www.astralcodexten.com/p/why-im-staying-out-of-the-substack
2•Michelangelo11•18m ago•1 comments

Reelaro – Full channel-to-post automation for video Shorts

https://reelaro.app
1•thorsBruda•20m ago•0 comments

OpenAI slows down training after its AI carried out hack

https://www.bbc.co.uk/news/articles/c235dmndylzo
1•Brajeshwar•20m ago•0 comments

Adding Error Bars to Evals: A Statistical Approach to Language Model Evaluations

https://arxiv.org/abs/2411.00640
1•Anon84•21m ago•0 comments