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Autism mutations drive neurodevelopmental pathology

https://www.science.org/doi/10.1126/science.ady4523
13•slantedview•1h ago

Comments

kayo_20211030•2m ago
I'm interested - for reasons. Does anyone have a sense of what this study means in a practical or actionable sense?

In toto, the conclusion of the paper:

> Together, these findings define a dual-layered model of molecular convergence in ASD: convergence through shared interaction networks in the wild-type state and convergence through recurrent functional consequences of interaction rewiring in the mutant state. More broadly, this work establishes a scalable framework for systematic interrogation of the autism proteome, enables prioritization of druggable protein interfaces, and provides a rational foundation for precision therapeutic strategies aimed at restoring neurodevelopmental trajectories.

I have no grounding here. Does anyone want to have a go at teasing the meaning out?

Stop VSCode from smashing your machine

https://blog.coderspirit.xyz/blog/2026/08/27/voracious-vscode/
1•speckx•44s ago•0 comments

Show HN: AgentCloud – MCP-first iOS simulator cloud

1•theo31•45s ago•0 comments

Logging in Was Never Supposed to Be This Complicated

https://www.theatlantic.com/technology/2026/08/password-manager-login-difficulty/688396/
1•blondie9x•5m ago•0 comments

There's a New Twitter in Town

https://techcrunch.com/2026/08/27/hold-up-theres-a-new-twitter-in-the-town/
1•NickNaraghi•6m ago•0 comments

Ratko Mladic, ex-Bosnian Serb warlord oversaw atrocities, dies in prison at 84

https://apnews.com/article/ratko-mladic-obit-03abf53803bef360978882d89024c475
2•petethomas•6m ago•0 comments

Show HN: OpenRouter Provider Economics

1•StratusBen•7m ago•0 comments

Show HN: Apronagents – give each AI coding agent a disposable Git remote

https://github.com/Ut8v/apronagents
1•utshavkhatiwada•8m ago•0 comments

AI Weeds Out Job Applicants with Disabilities, Lawsuit Claims

https://www.disabilityscoop.com/2026/08/25/ai-weeds-out-job-applicants-with-disabilities-lawsuit-...
2•speckx•8m ago•0 comments

Executive order changing name of lake-Ontario

https://www.washingtonpost.com/politics/2026/08/27/trump-signs-order-changing-name-lake-ontario/
3•nothrowaways•9m ago•0 comments

Show HN: Lumiko – Chrome screen recorder with automatic cursor zoom

https://lumiko.dev
1•Ashish106•9m ago•0 comments

LLM Fantasy Football Arena

https://arena.wildcardlabs.tech/draft
1•akcheese•10m ago•0 comments

I built a long-horizon AI harness that doesn't live in the chat

https://shotah.github.io/gantree/
1•christopher-blo•10m ago•0 comments

Maybe Nepo Baby – A Wikipedia extension that flags (maybe) famous parents

https://github.com/growse/maybe-nepo-baby-extension
1•growse•11m ago•1 comments

Free Internship Aggregator

https://lilguy.win/
1•asuramaya•11m ago•0 comments

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https://telem.ai/
3•yurikoif•11m ago•0 comments

He Vanished During the 1912 Olympic Marathon–Then Finished It 54 Years Later

https://www.runnersworld.com/news/a73427003/slowest-marathon-shizo-kanakuri/
1•canucker2016•13m ago•0 comments

Benchmarking Pocket-Scale Inference

https://artificialanalysis.ai/hardware-inference-stack/mobile-phones
1•sys42590•13m ago•0 comments

Government Is Inefficient, and (Partly) for Good Reason

https://morethandigital.info/en/government-is-inefficient-and-for-good-reason-partially/
1•colinprince•15m ago•0 comments

OpenAI, Anthropic issue dire cyber threat warning

https://www.axios.com/2026/08/27/openai-anthropic-issue-dire-cyber-threat-warning
1•dnw•15m ago•0 comments

Fewer Americans Pay to Use LLMs Than Still Pay to Play World of Warcraft

https://wjamesau.substack.com/p/fewer-americans-pay-to-use-chatgpt
4•SLHamlet•15m ago•0 comments

Golink: A private shortlink service for tailnets

https://github.com/tailscale/golink
1•colinprince•16m ago•0 comments

Get noticed in NYC on my backpack

https://brandmybackpack.lol
1•mattmerrick•17m ago•0 comments

Cartesia tops text-to-speech leaderboard with Sonic 3.6

https://www.cartesia.ai/blog/sonic-3.6
1•ganeshmm•18m ago•0 comments

Ask HN: How many of you juggle multiple agent sessions at the same time?

1•top_rooster•18m ago•0 comments

You Are Allowed to Reject LLMs

https://blog.edwardloveall.com/reject-llms
4•speckx•18m ago•0 comments

Mosaic – MCP Logic Puzzle

https://mosaic.dev.site/
1•FelineStateMach•19m ago•1 comments

Everyone hates datacentres. Do we need them? – video

https://www.theguardian.com/science/video/2026/aug/27/everyone-hates-datacentres-do-we-really-nee...
3•devonnull•19m ago•0 comments

Accountability

https://addisoncrump.info/research/on-accountability/
2•birdculture•20m ago•0 comments

Not American Enough

https://www.theatlantic.com/politics/2026/08/naturalized-citizens-ban-elected-office-trump/688415/
1•Jtsummers•20m ago•1 comments

Show HN: OpenWand – A mission to remove chat interface from working with AI

https://github.com/SunnyLich/OpenWand
2•OpenWand•21m ago•0 comments