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Alzheimer's trial to test drug on people without symptoms to test prevention

https://www.theguardian.com/society/2026/sep/05/alzheimers-trial-drug-dementia
6•borski•53m ago

Comments

orangecat•37m ago
Good. If https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h... is correct, the reason existing anti-amyloid drugs don't work well is amyloid leads to tau which leads to neurodegeneration, so by the time somebody is impaired by Alzheimer's they already have too much tau and reducing amyloid won't help much.

In Defense of Polyfills

https://lea.verou.me/blog/2026/polyfills/
1•eustoria•5m ago•0 comments

German startup sends first commercial rocket into space from Europe

https://www.theguardian.com/business/2026/sep/06/german-startup-sends-first-commercial-rocket-int...
1•giuliomagnifico•6m ago•0 comments

MotionSites AI – Official Premium AI Website Prompts

https://motionsites.ai/
1•eustoria•6m ago•0 comments

Dither Garden

https://www.dithergarden.com/
1•eustoria•7m ago•0 comments

Ask HN: I just learned of the term "Recall@K" – tell me more please?

1•consumer451•7m ago•0 comments

The aesthetic turn in intellectual property law copyright lessons from Pelham II

https://www.elgaronline.com/view/journals/qmjip/16/2/article-p99.xml
1•rbanffy•7m ago•0 comments

Ask HN: How safe are our password managers in face of LLM cyber attacks?

1•muddi900•10m ago•0 comments

If a startup worth your career

https://www.thetrueengineer.com/p/ego-equity-or-exit-checklist-to-decide
3•adletbalzhanov•13m ago•1 comments

Ask HN: Model Sycophancy Benchmarks?

1•gradus_ad•15m ago•0 comments

Show HN: Ontoplano, FOSS Life Management desktop and mobile app with MCP server

https://github.com/ontoplano/ontoplano
1•chedieck•15m ago•0 comments

The purpose of DNS is to spread scams

https://shkspr.mobi/blog/2026/09/the-purpose-of-dns-is-to-spread-scams/
3•edward•16m ago•0 comments

Show HN: Yume, a desktop workspace for Claude Code sessions

https://aofp.github.io/yume/
1•yuruko•18m ago•0 comments

YouTube Had a Bug – I Used ChatGPT to Investigate

https://blog.thezilber.com/3-youtube-had-a-bug-chatgpt-helped-me-to-investigate
2•theZilber•20m ago•0 comments

Casio 'CasioNaut' G-Shock GMC-2500 GAC-2500 Series: Price, Specs, Availability

https://www.wired.com/story/casio-g-shock-casionaut-looks-like-a-patek-philippe-classic/
2•joozio•21m ago•0 comments

Any Nix package, live in the browser

https://fzakaria.com/2026/09/04/any-nix-package-live-in-your-browser
5•domenkozar•21m ago•0 comments

Tinymongo

https://tinymongo.org/
2•schapman1974•23m ago•1 comments

GitHub Status – Disruption with Copilot Code Review

https://www.githubstatus.com/incidents/zw1hbx2yyhvr
1•kyisaiah47•23m ago•0 comments

Where Will RISC-V Be in 20 Years? Poll Results

https://thechipletter.substack.com/p/where-will-risc-v-be-in-20-years
2•rbanffy•23m ago•0 comments

Show HN: Layerz – Native App Designer

https://www.layerz.app/
1•jaeyoung_choi•25m ago•0 comments

Bitcoin mining data center condemned after leaking 3M gallons of water

https://www.tomshardware.com/tech-industry/data-centers/bitcoin-mining-data-center-condemned-afte...
3•rbanffy•25m ago•0 comments

How algorithms are making our environments bland

https://theconversation.com/how-algorithms-are-making-our-environments-bland-289917
1•geox•25m ago•0 comments

An off the self BYOA platform

1•theguysudo•26m ago•0 comments

The Man That Invented the Popup

https://galratner.substack.com/p/the-man-that-invented-the-popup
1•blartpaul•27m ago•0 comments

Washington Post says Piker used AI generated audio but admits it has no proof

https://twitter.com/washingtonpost/status/2096304873557877132
2•slowin•28m ago•0 comments

All of Claude's hilarious "Never Do This" in Fable 5.1 System Prompt

https://artifactbin.dev/@vivek/MLWEU6-claude-s-nevers
2•nuwandavek•28m ago•0 comments

Connecting Kubernetes dependencies to application telemetry

2•chipfixer•28m ago•0 comments

Big Brother is going to college: The federal plan to track students for life

https://www.washingtonexaminer.com/op-eds/4710733/college-transparency-act-student-privacy-risks/
3•iamnothere•30m ago•1 comments

Apex City – Build a city that works

https://apexcity.reallexi.io
1•m22386•32m ago•0 comments

FDA Recalls IV Fluids over Possible Fiberglass, Stainless Steel Contaminants

https://www.healthline.com/health-news/fda-recalls-iv-saline-fluids-fiberglass-stainless-steel-co...
4•speckx•32m ago•0 comments

The Association for Computational Heresy

https://sigbovik.org/
2•jerlendds•36m ago•1 comments