For thing Zepbound is the better drug and Lilly has kept up production. Lilly's new small-molecule drug
https://en.wikipedia.org/wiki/Orforglipron
has the potential of being cheaper to produce than peptide engineered products, in fact a better business because an incumbent manufacturer working at scale is likely to have a better cost structure than competitors to make a small molecule drug once it goes off patent. Still Orforlgipron is not that impressive in results causing a loss of just 8% of body weight which is not as good as the Wegovy Pill which manages 16% despite the difficulty of getting a peptide into people by the oral route.
randycupertino•44m ago
> Wegovy, the brand name for semaglutide for indications including obesity, is FDA-approved to reduce body weight in people aged 12 years and older. Yet Wegovy and other GLP-1 drugs are increasingly used off-label in younger children, with a recent study finding that prescriptions in kids aged 8 to 11 jumped from 0.03% in 2019 to 9.3% in 2026.
> Novo’s Step Young phase 3 trial suggests the younger children may benefit from Wegovy. Participants received weekly Wegovy injections of either 1.7 mg or 2.4 mg, based on their weight at the start of the trial, or placebo. All participants were assigned a reduced-calorie diet and increased physical activity.
> At baseline, more than 85% of the children had either class 2 or 3 severe obesity, corresponding to a BMI of at least 35 or 40 in adults, respectively. At Week 68, 40.4% of patients on Wegovy were no longer classified as having obesity, compared to 0% of their peers on placebo. The result reflects the effect if all children adhered to treatment.
> “We are encouraged by the positive Step Young results and semaglutide’s potential to help children living with obesity who need medical treatment, alongside lifestyle changes, to better manage their obesity,” Martin Holst Lange, M.D., Ph.D., chief scientific officer at Novo, said in a statement. “This may prevent serious health risks later in life.”
> Obesity is increasingly common in younger children, with one study finding that 20.7% of kids aged 6 to 11 in the U.S. have the condition. Weight-related complications emerge earlier and more severely in people who have obesity from a young age.
> Novo plans to share detailed trial results at ObesityWeek 2026 in November. The topline press release lacks safety and tolerability data, with Novo only saying that the profile was consistent with other trials and free from concerns about growth or pubertal development.
> The readout comes as Novo works to get back on track after a bruising period in which it lost ground in obesity to Eli Lilly. The launch of an oral formulation of Wegovy has given Novo renewed momentum this year, with the product making and maintaining a fast launch despite competition from Lilly’s Foundayo.