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Opus 5.5 refuses basic molecular biology questions

https://bede.im/2026/09/24/open-models-biology.html
2•bede•59m ago

Comments

hungryhobbit•37m ago
I setup Claude (Opus 5.5) to prepare code reviews for me, and the prompt it got given had the word "reasoning" in it.

IT BAILED ON THE ENTIRE SESSION BECAUSE THE CLASSIFIER REJECTED IT, AND WOULDN'T EVEN TELL ME WHAT LINE OR TOKENS OFFENDED THE CLASSIFIER!!!

Eventually I got a different Claude (Opus 4.6, my go to for "when Claude was good") to open up the session transcript, and it quickly found that the classifier rejected it because of that one word, "reasoning". Evidently the classifier "thought" (which is being way to generous, since it's clearly just a regular expression) I was trying to hack Claude and figure out how it reasoned.

Millions (billions?) of dollars in research creating the model ... and then Anthropic paid one dev for half an hour of vibe coding with zero thought behind it, which disables those millions/billions of dollars of research (and makes me hate the company and their product instead of loving it).

All that investment wasted because they cheaped out and didn't have the most minimal human involvement in their own development (we know as much because any human dev would have instantly rejected the idea that any prompt with "reasoning" in it should be blocked). If that isn't irony I don't know what is.

hungryhobbit•24m ago
P.S. It's also worth noting any decent human developer would almost certainly have had this thought:

"Hey, we are changing the classifier that handles every prompt a customer makes, and we also have access to (literally) millions of past prompts. MAYBE we should use a subset of those prompts to test that our classifier doesn't block legitimate prompts?"

But again, when your AI does all your dev for you (not just the coding but the thinking also), you don't get the benefit of the above.

Security headers on 4,688 small-business websites: 49.7% met none of 7 criteria

https://rackcrunch.com/security-headers-2026
1•terrybyte•1m ago•0 comments

Devenv 2.4: Machines

https://devenv.sh/blog/2026/09/24/devenv-24-machines/
1•domenkozar•3m ago•0 comments

California Is Chasing Wealth That Has Feet

https://blog.landeconomics.org/p/california-is-chasing-wealth-that
1•idbnstra•9m ago•1 comments

ESP32: The Arduino Rivals That Changed the Game

https://www.petkovsky.sk/esp8266-esp32-the-arduino-rivals-that-changed-the-game/
1•ex-aws-dude•9m ago•0 comments

Zeal – Offline Documentation Browser

https://zealdocs.org/
2•smartmic•11m ago•0 comments

Oracle triggers 'force majeure' on data center project over power delays

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1•vrganj•12m ago•0 comments

Issue Graph

https://github.com/vercel-labs/issue-graph
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DDoS Attack Breaks Beloved Video Game Wiki After AI Bro Was Banned

https://kotaku.com/ddos-attack-breaks-beloved-video-game-wiki-after-ai-bro-was-banned-2000729335
3•MBCook•14m ago•0 comments

Opus 5.5 is good at explainer videos

https://launchvideo.io
2•iacguy•15m ago•0 comments

Bosphore 1819: Reviving a 200-Year-Old Map of Istanbul with Opus 5.5

https://twitter.com/cahidarda/status/2103218970115678497
1•cahid_arda•15m ago•1 comments

Anthropic Strikes $12B AI Computing Deal with Akamai

https://www.bloomberg.com/news/articles/2026-09-24/anthropic-strikes-12-billion-deal-with-akamai-...
3•mfiguiere•16m ago•0 comments

Show HN: RentBench – Levels.fyi for UK Rents

https://rentbench.fyi
2•lluiscamino•17m ago•0 comments

The Tao of Acme

https://chai.guru/pub/plan9/mirrors/tao-of-acme.html
1•naltun•18m ago•1 comments

Mamdani is the most popular elected official in NYC: poll

https://www.nydailynews.com/2026/09/23/mamdani-is-the-most-popular-elected-official-in-nyc-poll/
3•downbad_•18m ago•0 comments

Democratic megadonor who gave to Gavin Newsom and Kamala Harris linked to murky

https://nypost.com/2026/09/22/us-news/california-donor-faces-scrutiny-over-alleged-chinese-spy-ties/
1•harry_nutsachs•18m ago•0 comments

Probing picosecond depairing currents in type-II superconductors

https://www.nature.com/articles/s41567-026-03469-z
2•PaulHoule•21m ago•0 comments

Ask HN: How would you know if you have learned something?

2•rearview•22m ago•0 comments

SciUniverse: Can frontier models carry out scientific work?

https://c5r.net/sciuniverse/
7•famouswaffles•24m ago•0 comments

Compio: A thread-per-core async Rust runtime with IOCP/io_uring/polling

https://github.com/compio-rs/compio
4•bootlegbilly•27m ago•0 comments

Swarm Scaling

https://www.tobyord.com/writing/swarm-scaling
2•louiereederson•32m ago•0 comments

Cracking VFPU math functions using Claude (Sony PSP)

https://www.ppsspp.org/blog/vfpu-math-re/
3•hrydgard•34m ago•1 comments

ZeroDrift – A small model that finds and fixes compliance violations

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2•chobberoni•35m ago•0 comments

Show HN: Dunara

https://dunara-studio.com/
1•grebmann•35m ago•0 comments

Flux 3 Action Tops RoboLab, but Large Companies Can't Use It in a Product

https://topicqueue.substack.com/p/flux-3-action-tops-robolab-but-larger
1•DISCURSIVE•36m ago•0 comments

Astronomers capture an unprecedented view of gas giant formation in action

https://phys.org/news/2026-09-astronomers-capture-unprecedented-view-gas.html
4•PeterCorless•37m ago•0 comments

China Holds Sensitive F-35 Parts Diverted to Hong Kong from Australia

https://www.bloomberg.com/news/articles/2026-09-23/china-is-holding-sensitive-f-35-parts-diverted...
4•rbanffy•39m ago•2 comments

The "C" Word

https://blog.coredump.cx/p/the-c-word
2•zdw•39m ago•1 comments

Restaurants Are Using AI to Advertise Their Food and It's Making People Sick

https://www.wsj.com/tech/ai/restaurants-ai-food-image-generators-advertisements-efb787a9
3•victor106•40m ago•0 comments

Topcoat is pushing the boundary of server applications with Rust

https://tokio.rs/blog/2026-09-24-topcoat-server-applications
3•carllerche•41m ago•0 comments

Global Chat

https://global-chat.jojoban842.workers.dev/
1•theredpainter•41m ago•0 comments