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Linux 7.4 Introduces DMA-BUF Support to I/O Path with IO_uring

https://www.phoronix.com/news/DMA-BUF-IO-uring-Linux-7.4
1•dabinat•53s ago•0 comments

Anthropic's 'Adjusted' Profit Exposes Wall Street's Earnings Game

https://www.wsj.com/finance/investing/anthropics-adjusted-profit-exposes-wall-streets-earnings-ga...
1•JumpCrisscross•2m ago•0 comments

BYD’s $10,000 EV blows a tire at nearly 90 mph — Watch what happens

https://electrek.co/2026/10/27/byds-10k-ev-blows-tire-nearly-90-mph-watch-what-happens/
2•cisc•3m ago•0 comments

Build IKEA Step by Step

https://www.usebygga.com
1•plurby•4m ago•0 comments

Apple Studio Display XDR Scrolling Stutter on the M5 Pro

https://macanorak.com/studio-display-xdr-scrolling-stutter-on-the-m5-pro-macbook-pro-whats-going-...
2•bhj•5m ago•0 comments

Microsoft Is Trying to Shed a Lot of Workers. Just Don't Call It a Layoff

https://www.wsj.com/business/microsoft-job-cuts-buyout-offers-ff3c5dde
4•JumpCrisscross•7m ago•0 comments

No One Needs Us Anymore [video]

https://www.youtube.com/watch?v=zONGVaONKe8
2•duck•11m ago•0 comments

China Claims Strong Economic Growth, but Skeptics Question Official Figures

https://www.wsj.com/economy/china-claims-strong-economic-growth-but-skeptics-question-official-fi...
1•JumpCrisscross•11m ago•0 comments

Show HN: Spend Extra AI Usage Transcribing Murray's New English Dictionary

https://github.com/timjonez/new-english-dictionary
1•dvorak007•12m ago•0 comments

Ask HN: When did HN become inconsistent algorithmic feed?

1•bosshawg•14m ago•0 comments

iPhone Duo Complete Teardown [video]

https://www.youtube.com/watch?v=_Xe2JAoMwIA
1•chirau•18m ago•1 comments

Clean room, no decomp/recomp, all original Mac OS System 1

https://classick.net/about/
1•segaboy81•21m ago•0 comments

A Mathematical Theory of the Jacobian Lens

https://arxiv.org/abs/2610.31955
1•krackers•21m ago•1 comments

Breaking Ludwig's Unbreakable Code

https://medium.com/@mikehall314/breaking-ludwigs-unbreakable-code-2fd3e5925a48
1•mikehall314•22m ago•0 comments

The doorman fallacy in the age of AI

https://www.adriankrebs.ch/blog/ai-and-the-doorman-fallacy/
2•hubraumhugo•25m ago•0 comments

Cycle or Train: An Xteink Dashboard

https://whitebeard.blog/posts/cycle-or-train/
1•techbelly•26m ago•0 comments

Finding Panics with Call Graph Analyzer

https://tweedegolf.nl/en/blog/242/finding-panics-with-call-graph-analyzer/
2•ibobev•27m ago•0 comments

The Shift of Theseus – Toy Bit Provenance Abstract Domain

https://pypy.org/posts/2026/10/toy-bit-provenance.html
1•ibobev•27m ago•0 comments

iPhone Users Are Getting an Upgrade to Their Cape Service

https://www.cape.co/blog/iphone-users-are-getting-an-upgrade-to-their-cape-service
1•tony101•27m ago•0 comments

The reclusive quant billionaire coming into the light

https://www.ft.com/content/bc6bba42-0b33-4825-a2c5-cff9b8f5c591
2•bookofjoe•28m ago•1 comments

Sharing a boulder without a back end: files and previews on iOS

https://freshteapot.net/writing/sharing-boulders-without-a-backend/
1•freshteapot•28m ago•0 comments

An Evening with Berferd in Which a Cracker Is Lured, Endured, and Studied [pdf]

https://www.cheswick.com/ches/papers/berferd.pdf
1•ibobev•28m ago•0 comments

Head of ADL claims they are "cleaning up" AI and Wikipedia

https://twitter.com/infolibnews/status/2115106467460108731
2•newspaper1•29m ago•0 comments

Ask HN: Do u think there should be a auto recovery tool for agents?

1•willlzl•29m ago•0 comments

Finding Frequencies Without an FFT: Sinusoids as Autoregressive Models

https://www.sithankanna.com/posts/prony-method.html
2•hdit•30m ago•0 comments

Acoustic-piezoelectric energy model of the Great Pyramid (Zenodo preprint)

https://zenodo.org/records/23644594
1•psssst•31m ago•0 comments

Nanotyrannus skeleton sells for $47.3M in New York auction

https://www.bbc.com/news/articles/cmx28de233r2o
1•jhy•31m ago•0 comments

New Dwarf Planet Candidate in Our Solar System

https://rubinobservatory.org/news/rubin-first-dwarf-planet-candidate
3•pppone•31m ago•0 comments

Hurricane Katrina

https://en.wikipedia.org/wiki/Hurricane_Katrina
1•chistev•32m ago•0 comments

"The panic hasn't turned into patching" The PHP2Shell response

https://thenewstack.io/php2shell-unpatched-php-servers/
1•CrankyBear•32m ago•0 comments
Open in hackernews

Early progress on accelerating drug development with Claude

https://www.anthropic.com/research/early-progress-drug-development
41•dataking•1h ago

Comments

adamredwoods•49m ago
I have a rare disease with no cure. Id love to see how Claude can help with us, but I'm cautious what it can really advance. Murine models still take time, and clinical trials are slow. I would think most biotech companies lose money at these stages.

>> If Claude is to significantly increase the rate of new cures, we need to work with many more biotechnology firms and integrate Claude more deeply into their development processes

Sounds invasive.

dyauspitr•27m ago
Have you tried it yourself on their best available public model yet?
2001zhaozhao•33m ago
I like how there's a giant "chapter picker" pinned at the top of the web page, but there are only two chapters and the second chapter is a tiny blob at the end of the article.
vatsachak•17m ago
That's standard blog design though
Sarkie•28m ago
New cocaine?
ChrisMarshallNY•9m ago
We've had "research chemicals" for a couple of decades.

Some, do what it says on the tin.

Some...not so much.

The issue with any new chemical is full, comprehensive, regulated testing.

Dodgy folks aren't really so good, with that last part. They use their customers as guinea pigs.

yewenjie•25m ago
TBH, I am waiting for Mathocalypse-level progress in biology and medicine, but I guess that's not happening as fast, because it's the real world, human lives, etc., mostly etc.
redanddead•19m ago
That plus organs on a chip could be scalable and generate interesting data
enraged_camel•18m ago
Specifically, it's because the verification loops are much longer in applied sciences. In biology you need to wait for wet lab experiments, clinical trials, regulatory steps, etc. before you can call something "solved".

Since sequential steps are slow, I think we're going to see massive increases in parallelization. I'm not sure how the regulatory frameworks will keep up honestly.

slashdave•15m ago
> we're going to see massive increases in parallelization

Why? This is not an AI problem, it's an industry one. And if it was simple, it would already exist.

menaerus•7m ago
> And if it was simple, it would already exist.

Not necessarily. Many things are simply gatekept behind the door.

Bluestein•4m ago
> wet lab experiments, clinical trials, regulatory steps

I wonder what the unlock would be, if any, of having simulations substitute any (or all, in time) of these steps. Akin to the method used to train FSD cars, or robots.-

jon128•20m ago
Crossing fingers for LSD 2.0
ruther4d•16m ago
> Six Generate scientists used Claude Code to propose new designs for this part

“Generate scientist” … is that a real job like “prompt engineer”

traceroute66•11m ago
"Invent a new drug, make no mistakes"
mysterydip•2m ago
“One that won't make me nervous, wondering what to do. One that makes me feel like I feel when I'm with you.”
anigbrowl•5m ago
I think the dividing line between skilled and unskilled use of AI is 'machine, do magic' vs 'machine, do x, y and Z, thus and so, avoid i, j, k which knowledge is the fruit of bitter experience.' Being able to articulate what matters and why is the ultimate high level language.
inglor_cz•15m ago
The point about finding problems in documented processes (Enveda: manufacturing and filings) is unexpected but interesting. One of our civilizational problems is that the sheer volume of documentation has slowly exceeded capabilities of humans to produce it reliably and without flaws.

Same applies to construction projects, BTW.

fwlr•5m ago
Claude, you are a senior drug dealer. Get me my fix, make no mistakes.
slashdave•16m ago
Keep waiting
xhevahir•14m ago
I expect that AI use in the more axiomatic kinds of research will be well in advance of sciences that have a heavy, messy empirical foundation, like biology.