> "This is an observational study, and as such, no firm conclusions can be drawn about cause and effect. The researchers also acknowledge that their study was retrospective, and they weren't able to account for dose or length of gabapentin use."
“No casual link is proven” could be said about so much science, specifically medical science and other disciplines which limit research methods for ethical or practical constraints. So you end up with this comment in every front page post about an observational medical study. We could be discussing the actual research or its implications, instead of repeating a discussion on limitations of research methodology.
In addition, I find these types of critics to be a little too cynical even for my taste. There’s a whole group of people that feel smart by finding ways to dismiss scientific studies even when there is some actually interesting data being brought up.
Edit: clarity
Now I'm not so sure I want to take it. My saving grace is that I'm on the younger end and haven't taken it that long.
After reading the paper and looking into dosing I learned that I'm taking a tiny fraction of the normal dose. Wow. Learn something every day.
It is also not very potent but there is another drug that shares its mechanism that is potent in single digit mg amounts: pregabalin (Lyrica). It is potent and kinda sorta abusable (not really) and they both can produce a super mild but benzo-ish sedation for a couple hours for a day or two.
It is apparently a coincidence that the drug seemed to resemble GABA and got its name though. Strange.
I would love more info on this because I have been taking gabapentin for years due to nerve damage from having Guilliane-Barre syndrome.
Edit: Re-reading the article, i see 'The researchers also acknowledge that their study was retrospective, and they weren't able to account for dose or length of gabapentin use.' - this seems like a pretty gaping hole in trying to draw an kind of conclusion from this
Then we have the increase in incidence. The incidence rate is already small in those age groups, so even doubling it is a tiny number.
I'm going to stop taking it (I take something between 1/10 and 1/5 of my prescribed dose anyhow) and think about if the benefit to me is worth the added risk.
https://chatgpt.com/share/68709753-d2ec-8010-ba8b-e7b57d610e...
TLDR:
The paper offers an interesting signal that heavy gabapentin prescribing tracks with higher dementia/MCI diagnoses, especially in 35-64-year-olds. Yet substantial unmeasured confounding, possible reverse causality, and modest absolute risk increments mean we’re far from proving gabapentin is neurotoxic. It’s a reminder to prescribe purposefully, review regularly, and keep cognition on the monitoring checklist—but not a reason for abrupt discontinuation in patients who benefit.
So he takes pills for nausea that make him extremely drowsy.
So then he takes uppers, which bring back the nerve pain.
Cool study, I will share it with him. But I get the impression that he would prefer to be demented than paralysed with never pain.
These drugs _do_ help you to tolerate nerve pain, but do _not_ stop it. I found they led to my otherwise amazing memory developing "holes" - I knew I knew something, but I couldn't put my finger on it. As someone accused of having an eidetic memory (I'm not convinced) I found this really disturbing. I also felt more stupid, and less quick.
I've been off gabapentinoid medications for about 4 years. My pain is more "in my face", but I no longer feel retarded.
Note: The advice on the gabapentinoid box "May increase the effects of alcohol" is both warning and recommendation. It's not unknown for the mix to include open-eyed hallucinations.
GABA analogues are known to impact memory formation.
https://en.wikipedia.org/wiki/Gabapentin
> Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat neuropathic pain and also for partial seizures of epilepsy.. is [ONLY] moderately effective: about 30–40% of those given gabapentin for diabetic neuropathy or postherpetic neuralgia have a meaningful benefit.
Those with peripheral neuropathy should audit the total amount of Vitamin B6 in their diet and daily supplements. Try to keep the daily amount below 10mg. There have not yet been lawsuits to add bottle label warnings, but Australian regulators have issued a safety warning.
https://www.tga.gov.au/news/safety-alerts/health-supplements...
> Vitamin B6 (pyridoxine) is in lots of multivitamin and mineral supplements that can be bought in supermarkets, health food shops and pharmacies without a prescription. Many people are not aware that vitamin B6 can cause peripheral neuropathy, which results in tingling, burning or numbness usually in the hands and feet. Taking vitamin B6 even at low doses can cause peripheral neuropathy but people are more likely to get it if they are taking more than one supplement.
acomjean•7h ago
moomoo11•7h ago
mordechai9000•6h ago
duskwuff•7h ago
PaulHoule•6h ago
https://mastodon.social/@UP8/111687412198643478
Can't say gabapentin really helped with the pain but I sure slept well and...
I had terrible social anxiety earlier in my life but in this phase I was getting up every morning and calling people up and down the east coast first thing and working my way to the west coast with my BD guy, never sold anything but boy people told us a lot of things they shouldn't have told us (e.g. EADS was way over its head in a project for the NSA) and I can't go to my grave and say I didn't give a serious try for the idea I had.
Settled in a real job in a real office, doc said I should try quitting paroxetine. Wasn't hard at first but there was that day I got furious about the messes in the house and got 40,000 steps cleaning without going outside and that time I got a psychogenic fever and lost 15 pounds in 3 weeks and kept it off for a year. Then that guy in the upper left corner of that card went through a series of transformations like a character in an anime: first a cute little bunny, then an ugly thing the size of a large bear, then a giant robot maybe 30 feet tall, finally a Godzilla kind of creature maybe 300 feet tall. He posted plenty on HN using my account and made trouble for myself and other people until a crisis broke and I was like "WTF happened there?" and kinda retreated for a year until Lezengreber's book fell into my hand and revealed how I was different from other people (schizotaxia) and why I had that triple split.
If anything good came out of that time it was that I learned my chronic pain was due to TMJ and managed it and now my jaw bugs me maybe one day a month.
Quit smoking pot, had trouble sleeping, would get up in the morning and experience "paranoia towards objects" and have plates jump out my hands like a ouija board and bonk my head four times in a row getting something out of the fridge, it seemed like my wife was always trying to stand exactly where I was going to go next when I was getting ready in the morning. Presented really bad at my doc and got put on a tiny dose of quietapine at night. Helped with the sleep and had only one little bit of 'psychosis' since and been very easy to live with.
I've been worried about the long term effects of gabapentin so I have been backing off my dose. I'm worried about the quietapine too for that matter.
Got friends though who take benzodiazepines for anxiety and those look really dreadful. That really arrests your development, people like that will have the same conversation with you that they had 12 years ago and at least I am not like that.
I know someone who made it to 92 or so with dementia and he was a really nice guy who was totally confused but good natured and easy to live with. My worst fear is that I lose my compensation for my schizotypy (verbal IQ too high to measure really seems to help with that) when I get older and get really paranoid and mean so I do try to develop habits of benevolence but I don't have the deep practice that guy had.
Can say though that I have zero anxiety now I feel like I am an expression of a principle and, on a certain level, can't be defeated. Don't know how much is the meds and how much is maturity.
sonofhans•6h ago
ykonstant•2h ago