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Start all of your commands with a comma (2009)

https://rhodesmill.org/brandon/2009/commands-with-comma/
289•theblazehen•2d ago•95 comments

Software Engineering Is Back

https://blog.alaindichiappari.dev/p/software-engineering-is-back
20•alainrk•1h ago•10 comments

Hoot: Scheme on WebAssembly

https://www.spritely.institute/hoot/
34•AlexeyBrin•1h ago•5 comments

Reinforcement Learning from Human Feedback

https://arxiv.org/abs/2504.12501
14•onurkanbkrc•1h ago•1 comments

OpenCiv3: Open-source, cross-platform reimagining of Civilization III

https://openciv3.org/
717•klaussilveira•16h ago•217 comments

The Waymo World Model

https://waymo.com/blog/2026/02/the-waymo-world-model-a-new-frontier-for-autonomous-driving-simula...
978•xnx•21h ago•562 comments

Vocal Guide – belt sing without killing yourself

https://jesperordrup.github.io/vocal-guide/
94•jesperordrup•6h ago•35 comments

Omarchy First Impressions

https://brianlovin.com/writing/omarchy-first-impressions-CEEstJk
11•tosh•1h ago•8 comments

Making geo joins faster with H3 indexes

https://floedb.ai/blog/how-we-made-geo-joins-400-faster-with-h3-indexes
138•matheusalmeida•2d ago•36 comments

Unseen Footage of Atari Battlezone Arcade Cabinet Production

https://arcadeblogger.com/2026/02/02/unseen-footage-of-atari-battlezone-cabinet-production/
74•videotopia•4d ago•11 comments

Ga68, a GNU Algol 68 Compiler

https://fosdem.org/2026/schedule/event/PEXRTN-ga68-intro/
16•matt_d•3d ago•4 comments

What Is Ruliology?

https://writings.stephenwolfram.com/2026/01/what-is-ruliology/
46•helloplanets•4d ago•46 comments

Show HN: Look Ma, No Linux: Shell, App Installer, Vi, Cc on ESP32-S3 / BreezyBox

https://github.com/valdanylchuk/breezydemo
242•isitcontent•16h ago•27 comments

Monty: A minimal, secure Python interpreter written in Rust for use by AI

https://github.com/pydantic/monty
242•dmpetrov•16h ago•128 comments

Cross-Region MSK Replication: K2K vs. MirrorMaker2

https://medium.com/lensesio/cross-region-msk-replication-a-comprehensive-performance-comparison-o...
4•andmarios•4d ago•1 comments

Show HN: I spent 4 years building a UI design tool with only the features I use

https://vecti.com
344•vecti•18h ago•153 comments

Hackers (1995) Animated Experience

https://hackers-1995.vercel.app/
510•todsacerdoti•1d ago•248 comments

Sheldon Brown's Bicycle Technical Info

https://www.sheldonbrown.com/
393•ostacke•22h ago•101 comments

Show HN: If you lose your memory, how to regain access to your computer?

https://eljojo.github.io/rememory/
309•eljojo•19h ago•192 comments

Microsoft open-sources LiteBox, a security-focused library OS

https://github.com/microsoft/litebox
361•aktau•22h ago•187 comments

An Update on Heroku

https://www.heroku.com/blog/an-update-on-heroku/
437•lstoll•22h ago•286 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
32•1vuio0pswjnm7•2h ago•31 comments

PC Floppy Copy Protection: Vault Prolok

https://martypc.blogspot.com/2024/09/pc-floppy-copy-protection-vault-prolok.html
73•kmm•5d ago•11 comments

Was Benoit Mandelbrot a hedgehog or a fox?

https://arxiv.org/abs/2602.01122
26•bikenaga•3d ago•13 comments

Dark Alley Mathematics

https://blog.szczepan.org/blog/three-points/
98•quibono•4d ago•22 comments

How to effectively write quality code with AI

https://heidenstedt.org/posts/2026/how-to-effectively-write-quality-code-with-ai/
278•i5heu•19h ago•227 comments

Female Asian Elephant Calf Born at the Smithsonian National Zoo

https://www.si.edu/newsdesk/releases/female-asian-elephant-calf-born-smithsonians-national-zoo-an...
43•gmays•11h ago•14 comments

I now assume that all ads on Apple news are scams

https://kirkville.com/i-now-assume-that-all-ads-on-apple-news-are-scams/
1088•cdrnsf•1d ago•469 comments

Understanding Neural Network, Visually

https://visualrambling.space/neural-network/
312•surprisetalk•3d ago•45 comments

Delimited Continuations vs. Lwt for Threads

https://mirageos.org/blog/delimcc-vs-lwt
36•romes•4d ago•3 comments
Open in hackernews

FDA described as a "clown show" amid latest scandal; top drug regulator is out

https://arstechnica.com/health/2025/11/fda-described-as-a-clown-show-amid-latest-scandal-top-drug-regulator-is-out/
165•duxup•3mo ago

Comments

duxup•3mo ago
>In early August, soon after joining the FDA, Tidmarsh announced actions that would effectively remove from the market a drug ingredient made by a company associated with Tang. Tidmarsh’s lawyer then sent a letter to Tang proposing that he extend a “service agreement” for “another 10 years,” which would see Tang making payments to a Tidmarsh-associated entity until 2044. The email was seen as attempted extortion, with such payments being in exchange for Tidmarsh rolling back the FDA’s regulatory change.

Straight up extortion.

Kapura•3mo ago
it's crazy how much of the current regime's position is "crime is legal if it's my guys doing it."
watwut•3mo ago
To be fair, that was always conservative position.

Edit: I do not mean it cynically or as a joke. I think that is exactly what conservative position was for years. The only difference now is that it is not possible to euphemism away or plausible deniality away out of it.

smithoc•3mo ago
It's not, and the current administration isn't conservative.

The MAGA movement has completely purged all the conservatives from the Republican party.

They've increased the deficit by a trillion dollars, built an army of ICE agents and deployed them to terrorize people in cities around the country, added billions of dollars in import taxes, taken state ownership stakes in multiple companies.

They're closer to Stalin or Mao than to any conservative ideology of a small government that stays out of people's business.

tastyface•3mo ago
And yet the non-MAGA Republicans in Congress are (almost) fully complicit. After all, just a handful of their votes would be sufficient to shutter the whole operation.
teddy-smith•3mo ago
This makes me wonder how much of the Tariffs are extortion of other countries.

How randomly they seem to be applied to makes me wonder if theres back room deals going on.

yongjik•3mo ago
Trump tariffs are extortion. It's orthogonal to whether it's a good policy for the US, but nobody outside the US has any doubt about it being extortion. It's not even a back room deal kind of stuff; "Give America your money or I'll raise tariffs" is how Trump is openly talking to every country.
tastyface•3mo ago
Backroom? The Korean government publicly gifted Trump a golden crown just last week!
yongjik•3mo ago
Well as a Korean I can't say I'm proud of what happened, but if the choice is between "get robbed by someone who fancies himself a king" and "get robbed by someone who fancies himself a king, but also get a nuclear submarine deal" ...
vibrio•3mo ago
“He had the temerity to reject a drug that had lousy data…”

Was that data really “lousy”? (Referencing the REPL data?) Was it a trial design issue? (which he has very strong and unconventional opinions on) Is it the role of his position to overrule his specialist review teams ? (in the absence of any clear safety risks or malfeasance)

ubiquitysc•3mo ago
At least clowns can be fun to watch
_carbyau_•3mo ago
From another country, it is mildly amusing in one sense of schadenfreude.

It is also incredibly saddening to see great institutions of expertise be treated as playthings by the ignorant.

vibrio•3mo ago
It’s much less fun if you have a loved one, say an aggressive autoimmune disease. Do not recommend.
pstuart•3mo ago
My ex works in QA for a biotech company and FDA audits are a regular thing and are taken very seriously.

There's plenty to criticize of the org (as with almost all others) but the rank and file are doing good work to help try to keep us safe.

wswope•3mo ago
I work in biotech and the FDA is openly reviewing our submissions with LLMs now. The shark has been jumped.

https://www.fda.gov/news-events/press-announcements/fda-anno...

teddy-smith•3mo ago
I don't know. If this speeds up their work and helps them do more with the same staff I can see this as being a good thing. a.i. is really good at combing through data to answer questions.
Balgair•3mo ago
It will not.

One (of many) issue is that this has no bearing on other regulatory regimes. So, sure, the FDA approves of the drug/device/thingy because the AI got lost and no one is checking what it's saying. But Canada's CFIA doesn't because they are still using real people or centaurs ( people + AI, but I'm not 100% sure so don't quote me on that ).

That makes it so that you can only sell the drug/device/thingy in the US and some other countries that blindly follow US FDA (mostly poorer nations with very small markets and a lack of legal recourse, they'll just turn to the EFSA/EMA).

Which fine, but that is not the bet that these large companies made about a decade ago when it came to whether or not this drug/device/thingy would be worth it to pursue. These big drugs need to pay off all the failed research with international sales. Same is somewhat true with devices (mostly internal these days). These big drug makers want stability. Profits are fine, but revenue is just as important as these pipelines are sooooo long and soooo fraught. The human body is just too variable.

The tariffs and all the monkey business with this admin is very much not good for the US when it comes to these large drug/device/thingy makers. Chaos is not good for business. They have all learned that Donny and his ilk (per the article here) do not keep their words when it comes to corruption. They do not stay bought, they are not stable.

We're already shedding jobs here in favor of moving to the EU. Yes, not India or China, but the Baltics mostly (inside Schengen zone). We lost 10 people with jobs opening up there (same day) just this last week. The EU is stable in the eyes of my very own bosses.

KuhlMensch•3mo ago
> not India or China, but the Baltics mostly

Interesting.

So you're seeing "scientific development" pipelines (research/development/trials) moving wholesale to EU?

Balgair•3mo ago
In parts for now, not wholesale yet. And more than just RnD, it's other sectors of the corpo too.
cameldrv•3mo ago
Waiting to see the job posts popping up for a prompt engineer for FDA submissions.
vibrio•3mo ago
This. They don’t get paid much, or much glory if any, but overall they are smart and hard working and are eager to have rational and data driven discussions about the programs they oversee. Current status is heartbreaking.
cosmicgadget•3mo ago
And they are slowly being attrited by layoffs, being led by corrupt shitbirds, and the Russell Vought ethos of making career public servants miserable.