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Show HN: CUDA, Shmuda: Fold Proteins on a MacBook

https://latentspacecraft.com/posts/mlx-protein-folding
7•geoffitect•3h ago
Alphafold3 used to be fodder for HPC clusters; now I've got a port running smoothly on Apple Silicon. If you have an M-series Mac (~2023-present), you can generate protein structures from sequences in minutes. Give it a try!

GitHub repo: https://github.com/latent-spacecraft/openfold-3-mlx

Comments

cyrusradfar•2h ago
Curious to try, thanks for putting this out.

What did you find to be the most surprising challenge in this project?

geoffitect•2h ago
^How convoluted MSA and template handling is under the hood in openfold. I’m working on a simple offline replacement next. Compared to that, the attention functions were fairly easy to convert to MLX ops.

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Show HN: CUDA, Shmuda: Fold Proteins on a MacBook

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