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Show HN: GeneGuessr – a daily biology web puzzle

https://geneguessr.brinedew.bio/
27•brinedew•2d ago•7 comments

Show HN: Gaming Couch – a local multiplayer party game platform for 8 players

https://gamingcouch.com
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Show HN: Domain Search MCP – AI-powered domain availability checker

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Show HN: Exploring Mathematics with Python

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Show HN: A Claude Code plugin that catch destructive Git and filesystem commands

https://github.com/kenryu42/claude-code-safety-net
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Show HN: Vibium – Browser automation for AI and humans, by Selenium's creator

https://github.com/VibiumDev/vibium
423•hugs•1d ago•116 comments

Show HN: I embedded 10M StreetView images

https://view.geospot.sdan.io/
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Show HN: I treated my brain like a buggy server and wrote a patch (Shi-Mo Model)

https://github.com/317317317apple-a11y/shi-mo-protocol/blob/main/README.md
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Show HN: Why many AI-generated websites don't show up on Google

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Show HN: CineCLI – Browse and torrent movies directly from your terminal

https://github.com/eyeblech/cinecli
339•samsep10l•3d ago•106 comments

Show HN: I built an OCI container runtime in Python(for fun)

https://github.com/Kaleab-Ayenew/puncker-rt
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Show HN: Frame an web synth for desktop or mobile with hand gesture support

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Show HN: Kill List–A local-first PWA where tasks deletes if not done by midnight

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Show HN: Turn raw HTML into production-ready images for free

https://html2png.dev
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Show HN: A local-first, reversible PII scrubber for AI workflows

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Show HN: Typed-Prompts – Type-Safe Prompt Engineering

https://github.com/f/awesome-chatgpt-prompts/tree/main/packages/prompts.chat
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Show HN: FIDO2 PRF with TPM and Fingerprint Auth for Confer on Linux

https://vitorpy.com/blog/2025-12-25-confer-to-linux-tpm-fido2-prf/
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Show HN: OmniWM a macOS tiling window manager Niri inspired

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Show HN: Pivor, Open source self-hosted CRM

https://github.com/Lexaro-Software/pivor
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Show HN: I Updated My 2D Ant Game for the Holidays

https://github.com/aanthonymax/ant-and-apples
3•aanthonymax•14h ago•0 comments

Show HN: Microsoft Agent Viewer

https://acs-viewer.pages.dev/
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Show HN: CLI to share secrets using one-time public keys

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3•scosman•14h ago•0 comments
Open in hackernews

Show HN: GeneGuessr – a daily biology web puzzle

https://geneguessr.brinedew.bio/
27•brinedew•2d ago
I made a web game inspired by Geoguessr and Wordle, where you get shown a 3D model of a random human protein each day, and you have to triangulate its gene name using similarity clues.

My background is in wet lab molecular biology and I intend this game to be engaging mostly to other biologists. But if you're outside the field, I'm interested to know if you can still solve it with browser use LLMs, and if you learned something interesting doing so. Let me know what you think.

I made it with Claude over the last 2 months. My coding experience is limited to basic python data analysis and figure making. I've seen people online asking, "Now that we have coding AI, why isn't there a deluge of awesome AI-generated apps made by non-coders?" - if this sounds like you, check out Geneguessr to understand what a web app by a non-coder looks like.

I might write more about the process if there's a demand, but what really unlocked the project for Claude was Linear MCP, where it could put each individual issue on a shared Kanban board. This, and Playwright MCP for testing on live site, were the two workhorses that got me through this. For bugs Claude couldn't one-shot, Linear was great for consolidating issue information so that I could dump it into ChatGPT Codex - it would usually think for like half an hour, output very confusing explanations, but the bug was gone.

Game is free, no log-in required, sorry if you run into any mobile bugs - didn't test it much there.

https://geneguessr.brinedew.bio/

Comments

miladyincontrol•2h ago
For a moment thought this was gonna be some ethnoguessr clone
lovegrenoble•2h ago
Dayly, that means one puzzle per day? And how many of them in total?
brinedew•1h ago
You can play more than once in the practice mode. It turns on after you complete the daily puzzle.

There's almost 20k entries in my human gene database. You can choose any of them as your guess, but the "gene of the day" is chosen from a subset that has decent 3D structure coverage (meaning, not falling back to alphafold2 for visualization).

noduerme•1h ago
Huh. Is this kind of manifold something that a group of humans can now identify on sight and associate with a part of a DNA sequence? That's pretty spectacular. I have a friend who worked for years on AlphaFold, but wasn't aware that people had gotten to this level of confidence in visually identifying proteins.
brinedew•1h ago
My dream is forming a team of Tetlock-style superbiologists who can identify gene names on sight like Rainbolt, beat prediction markets on shorting biotech stocks, and smell out pre-cancerous cells like it's the final round of amongus.
noduerme•1h ago
Hahahaa ... I kinda love this, along with humans who can sit at a piano and play a song they've only heard once, or cook a complicated dish they only tasted once. That seems like the great Turing test... zero-shot humans.

But seriously, there probably are a few people who can see genes from proteins like that, faster than a whole datacenter of GPUs. Putting together such a brain trust could be invaluable.

wigglewoggle•1h ago
I went straight to cd-4 and was crushed to find out I didn't get it in one guess