frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

Open in hackernews

Why Did DeepMind Solve Protein Folding?

https://jakefeala.substack.com/p/why-did-deepmind-solve-protein-folding
2•barry-cotter•6h ago

Comments

jleyank•6h ago
They didn’t solve protein folding, in that they did not generate an explanation as to why common structural motifs are common, etc. people have been trying to explain things at that level for decades.

What it did was provide a perhaps better, perhaps more general structure generator than existing tools such as protein homology. Both, I think, rely on structural similarity as a means of guesstimating the structure of a new protein. No clue how any of these approaches would work with truly novel structures that are outside the training set.

A first principles approach would probably do better as the energetics of the structural motifs would be modeled properly.

China Drops to No. 3 Holder of Treasuries, Falling Behind UK

https://www.bloomberg.com/news/articles/2025-05-16/china-falls-to-no-2-holder-of-treasuries-with-uk-on-the-rise
2•JumpCrisscross•50s ago•0 comments

Mice grow bigger brains when given this stretch of human DNA

https://www.nature.com/articles/d41586-025-01515-z
2•bookofjoe•2m ago•1 comments

US Credit Rating Cut by Moody's on Government Debt Increase

https://www.bloomberg.com/news/articles/2025-05-16/us-credit-rating-cut-by-moody-s-on-government-debt-increase
4•JumpCrisscross•2m ago•1 comments

Sloppy software is why you think you need new hardware

https://www.neowin.net/editorials/sloppy-software-is-why-you-think-you-need-new-hardware/
2•bundie•2m ago•0 comments

Moody's Ratings Downgrades United States Ratings to Aa1 from Aaa

https://www.moodys.com/web/en/us/about-us/usrating.html
1•ortusdux•5m ago•0 comments

When Should a SaaS App Implement SAML Authentication?

1•andy89•6m ago•0 comments

Top Priority for Pope Leo: Warn the World of the A.I. Threat

https://www.nytimes.com/2025/05/15/world/europe/pope-leo-artificial-intelligence.html
2•nanfinitum•7m ago•1 comments

A Skeptical Look at Grand Designs for the Future

https://undark.org/2025/05/16/book-review-more-everything-forever/
1•EA-3167•8m ago•0 comments

Coinbase says customers' personal information stolen in data breach

https://techcrunch.com/2025/05/15/coinbase-says-customers-personal-information-stolen-in-data-breach/
2•riffraff•9m ago•0 comments

Font Activations: A Note on the Type

https://robhorning.substack.com/p/font-activations
2•prismatic•10m ago•0 comments

Scaling Python Task Queues Effectively

https://judoscale.com/blog/scaling-python-task-queues
1•rbanffy•12m ago•0 comments

New Research Shows Online Ads Have Limited Impact on Consumer Valuation for Meta

https://www.heinz.cmu.edu/media/2024/August/new-research-shows-online-ads-have-limited-impact-on-consumer-valuations-for-facebook
1•dpflan•12m ago•0 comments

Environmentally-Beneficial Housing Exemption

https://cayimby.org/legislation/ab-609/
1•JumpCrisscross•17m ago•0 comments

Solving physics-based initial value problems with unsupervised machine learning

https://link.aps.org/doi/10.1103/PhysRevE.111.055302
1•opnac•17m ago•0 comments

OnTrack Goals Habits Tracker App

https://apps.apple.com/us/app/ontrack-goals-habits-tracker/id6742162476
1•marcoavantitec•18m ago•1 comments

Big tech's new datacentres will take water from the driest areas

https://www.theguardian.com/environment/2025/apr/09/big-tech-datacentres-water
2•anticorporate•21m ago•0 comments

Writer's Block and Other Tales of the Unexpected

https://www.amazon.co.uk/dp/B0F8VMP5G2
1•judgementday•21m ago•0 comments

Show HN: Self-Funded Game with Homemade Engine – Play Online, Steam Coming

https://bereprobate.com
3•delduca•23m ago•1 comments

The Universe May End Sooner Than Scientists Had Expected

https://www.space.com/astronomy/scientists-calculate-when-the-universe-will-end-its-sooner-than-expected
1•anticorporate•23m ago•0 comments

Moody's strips US of top-notch triple-A credit rating

https://www.ft.com/content/e456ea34-c6ad-43fe-abe9-d4ce781c07b4
13•Anon84•23m ago•3 comments

Permacomputing

https://permacomputing.net/permacomputing/
2•GTP•26m ago•0 comments

A Search for Planet Nine with IRAS and Akari Data

https://arxiv.org/abs/2504.17288
1•asparagui•27m ago•0 comments

Voyager 1's Primary Thrusters Revived Before DSN Command Pause

https://hackaday.com/2025/05/15/voyager-1s-primary-thrusters-revived-before-dsn-command-pause/
4•droideqa•32m ago•0 comments

Come celebrate the Amiga/040th VCF West

https://amigameditation.guru/
2•doener•34m ago•0 comments

I asked 100 people in Hollywood about AI

https://twitter.com/AIVideoDotCom/status/1923453017145102498
6•inventtheday•35m ago•1 comments

Coinbase shares dive on NYT report of SEC investigation

https://www.cnbc.com/2025/05/15/coinbase-shares-dive-on-new-york-times-report-of-sec-investigation.html
1•1vuio0pswjnm7•38m ago•0 comments

Show HN: Lailaims – Talk to multiple LLMs at once

https://lailaims.pages.dev/
3•youz•39m ago•0 comments

Show HN: Solidis – Tiny TS Redis client, no deps, for serverless

https://github.com/vcms-io/solidis
9•jayl-e-e•42m ago•1 comments

Getting AI to write good SQL: Text-to-SQL techniques explained

https://cloud.google.com/blog/products/databases/techniques-for-improving-text-to-sql
23•richards•52m ago•5 comments

A Ledger in PostgreSQL Is Fast

https://www.pgrs.net/2025/05/16/pgledger-in-postgresql-is-fast/
3•pgr0ss•57m ago•0 comments