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Cholesterol treatment can cut levels by 69% after one dose

https://www.sciencefocus.com/news/new-cholesterol-treatment-could-be-revolutionary-verve
33•nreece•1d ago

Comments

AStonesThrow•1d ago
Artificially cutting high cholesterol levels is like killing the astronauts to solve a CO2 buildup.
lifeplusplus•1d ago
When there are fires number of fire trucks go up so this new law will out law the fire trucks, that ought to control the fires
thathndude•1d ago
This guy gets it. Cholesterol is the symptom.
Kirby64•1d ago
The symptom of what? Bad genes? Because plenty of people have genetically high cholesterol that doesn’t do anything for you besides cause you to have a high risk of cardiovascular disease later in life from years of elevated cholesterol.
knodi•1d ago
Some people just have teflon lining in their arteries. Plaque up of cholesterol is not the only negative outcome of high cholesterol.
GuestFAUniverse•1d ago
Somehow that trait was evolutionary helpful (groupwise, not necessarily for a single being)?

E.g. low LDL, which is an anti-toxant to certain bacterial toxins, leads to a higher risks of sepsis.

In general just lowering _any_ cholesterol without understanding _all_ the cons and pros won't cut it. https://pmc.ncbi.nlm.nih.gov/articles/PMC8886946/

Kirby64•1d ago
> Somehow that trait was evolutionary helpful (groupwise, not necessarily for a single being)?

There’s plenty of people that have degenerative diseases with no perceivable benefit that are “evolutionary” favored due to genetics just working out that way. What does Huntington’s disease provide? Its a dominant gene, doesn’t typically effect people until they’re 30 or 40 past their prime child years.

> In general just lowering _any_ cholesterol without understanding _all_ the cons and pros won't cut it.

Pros: it significantly decreases long term of risk of cardiovascular disease later in life

Cons: the medications have to be taken daily forever, I guess.

This is just an argument from nature. If you have very high cholesterol, there’s no good reason to not lower it to sub-problematic levels.

lifeplusplus•1d ago
Overall populations don't have flawed genes... Before jumping on statins and such it's important fixing underlying cause and even then try to get actual data my having imagine to get soft plaque.. not cacb score which is only relevant in later stages

High cholesterol could be from high glucose/insulin damaging arteries

Or could also be from weight loss

Simplest fixes are

- eat low carb

- don't eat all day intermittent fasting

- walk after eating to lower spike

- eat olives which protects lining of veins and arteries

- avoid seed oils

- pick antiinflammatory foods and supplements

- take l-arginine and similar supplements, sunlight, green veggies, no mouth wash, exercise to increase nitrogen oxide production... Breath through nose as well

- exercise to increase good cholesterol

- sleep well and keep cortisol low (stress)

Cholesterol is needed for hormones, brain, everything... I believe statin are linked to Alzheimer

ack_inc•1d ago
Does the LDL cholesterol do anything useful when it's on the walls of arteries?
raylad•1d ago
Detailed discussion including how it works:

https://biotech.industryexaminer.com/gene-edit-to-lower-chol...

(It's gene-editing: puts in a premature stop codon in the PCSK9 gene preventing it from being expressed)

Terr_•1d ago
Their "conceptual illustration" picture has the word "colastrol" superimposed, is that AI slop—or perhaps a translation issue?
reify•1d ago
What always concerns me about all these new wonder drugs that hit the market.

Is that they are dangerous and useless.

Dangerous in that cutting 69% of your cholesterol.

we need cholesterol.

a money making machine designed by big pharma

I have lived on a ketogenic diet for over 20 years.

75% of my calory intake are made up of fats.

I eat a ton of high cholesterol foods

I an an old geezer. I have regular check ups at my GP.

My cholesterol levels are below average.

The research:

The study reviewed research of almost 70,000 people and found that elevated levels of “bad cholesterol” did not raise the risk of early death from cardiovascular disease in people over 60.

High cholesterol 'does not cause heart disease' new research finds, so treating with statins a 'waste of time'

https://www.telegraph.co.uk/science/2016/06/12/high-choleste...

amluto•1d ago
There are people who naturally have non-functioning PCSK9, the gene that this new treatment disables. And they have less heart disease.
tchock23•1d ago
It’s great you’ve been able to maintain a keto diet for over 20 years (longest I’ve ever heard of), but most people can’t do strict keto for that long. Long-term adherence is the issue.

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