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Show HN: Poddley.com – Follow people, not podcasts

https://poddley.com/guests/ana-kasparian/episodes
1•onesandofgrain•5m ago•0 comments

Layoffs Surge 118% in January – The Highest Since 2009

https://www.cnbc.com/2026/02/05/layoff-and-hiring-announcements-hit-their-worst-january-levels-si...
3•karakoram•5m ago•0 comments

Papyrus 114: Homer's Iliad

https://p114.homemade.systems/
1•mwenge•5m ago•1 comments

DicePit – Real-time multiplayer Knucklebones in the browser

https://dicepit.pages.dev/
1•r1z4•5m ago•1 comments

Turn-Based Structural Triggers: Prompt-Free Backdoors in Multi-Turn LLMs

https://arxiv.org/abs/2601.14340
2•PaulHoule•7m ago•0 comments

Show HN: AI Agent Tool That Keeps You in the Loop

https://github.com/dshearer/misatay
2•dshearer•8m ago•0 comments

Why Every R Package Wrapping External Tools Needs a Sitrep() Function

https://drmowinckels.io/blog/2026/sitrep-functions/
1•todsacerdoti•8m ago•0 comments

Achieving Ultra-Fast AI Chat Widgets

https://www.cjroth.com/blog/2026-02-06-chat-widgets
1•thoughtfulchris•10m ago•0 comments

Show HN: Runtime Fence – Kill switch for AI agents

https://github.com/RunTimeAdmin/ai-agent-killswitch
1•ccie14019•13m ago•1 comments

Researchers surprised by the brain benefits of cannabis usage in adults over 40

https://nypost.com/2026/02/07/health/cannabis-may-benefit-aging-brains-study-finds/
1•SirLJ•14m ago•0 comments

Peter Thiel warns the Antichrist, apocalypse linked to the 'end of modernity'

https://fortune.com/2026/02/04/peter-thiel-antichrist-greta-thunberg-end-of-modernity-billionaires/
1•randycupertino•15m ago•2 comments

USS Preble Used Helios Laser to Zap Four Drones in Expanding Testing

https://www.twz.com/sea/uss-preble-used-helios-laser-to-zap-four-drones-in-expanding-testing
2•breve•20m ago•0 comments

Show HN: Animated beach scene, made with CSS

https://ahmed-machine.github.io/beach-scene/
1•ahmedoo•21m ago•0 comments

An update on unredacting select Epstein files – DBC12.pdf liberated

https://neosmart.net/blog/efta00400459-has-been-cracked-dbc12-pdf-liberated/
2•ks2048•21m ago•0 comments

Was going to share my work

1•hiddenarchitect•25m ago•0 comments

Pitchfork: A devilishly good process manager for developers

https://pitchfork.jdx.dev/
1•ahamez•25m ago•0 comments

You Are Here

https://brooker.co.za/blog/2026/02/07/you-are-here.html
3•mltvc•29m ago•1 comments

Why social apps need to become proactive, not reactive

https://www.heyflare.app/blog/from-reactive-to-proactive-how-ai-agents-will-reshape-social-apps
1•JoanMDuarte•30m ago•1 comments

How patient are AI scrapers, anyway? – Random Thoughts

https://lars.ingebrigtsen.no/2026/02/07/how-patient-are-ai-scrapers-anyway/
1•samtrack2019•30m ago•0 comments

Vouch: A contributor trust management system

https://github.com/mitchellh/vouch
2•SchwKatze•30m ago•0 comments

I built a terminal monitoring app and custom firmware for a clock with Claude

https://duggan.ie/posts/i-built-a-terminal-monitoring-app-and-custom-firmware-for-a-desktop-clock...
1•duggan•31m ago•0 comments

Tiny C Compiler

https://bellard.org/tcc/
2•guerrilla•33m ago•0 comments

Y Combinator Founder Organizes 'March for Billionaires'

https://mlq.ai/news/ai-startup-founder-organizes-march-for-billionaires-protest-against-californi...
2•hidden80•33m ago•3 comments

Ask HN: Need feedback on the idea I'm working on

1•Yogender78•34m ago•0 comments

OpenClaw Addresses Security Risks

https://thebiggish.com/news/openclaw-s-security-flaws-expose-enterprise-risk-22-of-deployments-un...
2•vedantnair•34m ago•0 comments

Apple finalizes Gemini / Siri deal

https://www.engadget.com/ai/apple-reportedly-plans-to-reveal-its-gemini-powered-siri-in-february-...
1•vedantnair•35m ago•0 comments

Italy Railways Sabotaged

https://www.bbc.co.uk/news/articles/czr4rx04xjpo
16•vedantnair•35m ago•4 comments

Emacs-tramp-RPC: high-performance TRAMP back end using MsgPack-RPC

https://github.com/ArthurHeymans/emacs-tramp-rpc
1•fanf2•37m ago•0 comments

Nintendo Wii Themed Portfolio

https://akiraux.vercel.app/
2•s4074433•41m ago•2 comments

"There must be something like the opposite of suicide "

https://post.substack.com/p/there-must-be-something-like-the
2•rbanffy•43m ago•1 comments
Open in hackernews

Cholesterol treatment can cut levels by 69% after one dose

https://www.sciencefocus.com/news/new-cholesterol-treatment-could-be-revolutionary-verve
34•nreece•8mo ago

Comments

AStonesThrow•8mo ago
Artificially cutting high cholesterol levels is like killing the astronauts to solve a CO2 buildup.
lifeplusplus•8mo ago
When there are fires number of fire trucks go up so this new law will out law the fire trucks, that ought to control the fires
thathndude•8mo ago
This guy gets it. Cholesterol is the symptom.
Kirby64•8mo ago
The symptom of what? Bad genes? Because plenty of people have genetically high cholesterol that doesn’t do anything for you besides cause you to have a high risk of cardiovascular disease later in life from years of elevated cholesterol.
knodi•8mo ago
Some people just have teflon lining in their arteries. Plaque up of cholesterol is not the only negative outcome of high cholesterol.
GuestFAUniverse•8mo ago
Somehow that trait was evolutionary helpful (groupwise, not necessarily for a single being)?

E.g. low LDL, which is an anti-toxant to certain bacterial toxins, leads to a higher risks of sepsis.

In general just lowering _any_ cholesterol without understanding _all_ the cons and pros won't cut it. https://pmc.ncbi.nlm.nih.gov/articles/PMC8886946/

Kirby64•8mo ago
> Somehow that trait was evolutionary helpful (groupwise, not necessarily for a single being)?

There’s plenty of people that have degenerative diseases with no perceivable benefit that are “evolutionary” favored due to genetics just working out that way. What does Huntington’s disease provide? Its a dominant gene, doesn’t typically effect people until they’re 30 or 40 past their prime child years.

> In general just lowering _any_ cholesterol without understanding _all_ the cons and pros won't cut it.

Pros: it significantly decreases long term of risk of cardiovascular disease later in life

Cons: the medications have to be taken daily forever, I guess.

This is just an argument from nature. If you have very high cholesterol, there’s no good reason to not lower it to sub-problematic levels.

lifeplusplus•8mo ago
Overall populations don't have flawed genes... Before jumping on statins and such it's important fixing underlying cause and even then try to get actual data my having imagine to get soft plaque.. not cacb score which is only relevant in later stages

High cholesterol could be from high glucose/insulin damaging arteries

Or could also be from weight loss

Simplest fixes are

- eat low carb

- don't eat all day intermittent fasting

- walk after eating to lower spike

- eat olives which protects lining of veins and arteries

- avoid seed oils

- pick antiinflammatory foods and supplements

- take l-arginine and similar supplements, sunlight, green veggies, no mouth wash, exercise to increase nitrogen oxide production... Breath through nose as well

- exercise to increase good cholesterol

- sleep well and keep cortisol low (stress)

Cholesterol is needed for hormones, brain, everything... I believe statin are linked to Alzheimer

ack_inc•8mo ago
Does the LDL cholesterol do anything useful when it's on the walls of arteries?
raylad•8mo ago
Detailed discussion including how it works:

https://biotech.industryexaminer.com/gene-edit-to-lower-chol...

(It's gene-editing: puts in a premature stop codon in the PCSK9 gene preventing it from being expressed)

Terr_•8mo ago
Their "conceptual illustration" picture has the word "colastrol" superimposed, is that AI slop—or perhaps a translation issue?
reify•8mo ago
What always concerns me about all these new wonder drugs that hit the market.

Is that they are dangerous and useless.

Dangerous in that cutting 69% of your cholesterol.

we need cholesterol.

a money making machine designed by big pharma

I have lived on a ketogenic diet for over 20 years.

75% of my calory intake are made up of fats.

I eat a ton of high cholesterol foods

I an an old geezer. I have regular check ups at my GP.

My cholesterol levels are below average.

The research:

The study reviewed research of almost 70,000 people and found that elevated levels of “bad cholesterol” did not raise the risk of early death from cardiovascular disease in people over 60.

High cholesterol 'does not cause heart disease' new research finds, so treating with statins a 'waste of time'

https://www.telegraph.co.uk/science/2016/06/12/high-choleste...

amluto•8mo ago
There are people who naturally have non-functioning PCSK9, the gene that this new treatment disables. And they have less heart disease.
tchock23•8mo ago
It’s great you’ve been able to maintain a keto diet for over 20 years (longest I’ve ever heard of), but most people can’t do strict keto for that long. Long-term adherence is the issue.
aiiizzz•8mo ago
Stop spreading misinformation.