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Obey the Testing Goat

https://www.obeythetestinggoat.com/
1•mkl95•48s ago•0 comments

Claude Opus 4.6 extends LLM pareto frontier

https://michaelshi.me/pareto/
1•mikeshi42•1m ago•0 comments

Brute Force Colors (2022)

https://arnaud-carre.github.io/2022-12-30-amiga-ham/
1•erickhill•4m ago•0 comments

Google Translate apparently vulnerable to prompt injection

https://www.lesswrong.com/posts/tAh2keDNEEHMXvLvz/prompt-injection-in-google-translate-reveals-ba...
1•julkali•4m ago•0 comments

(Bsky thread) "This turns the maintainer into an unwitting vibe coder"

https://bsky.app/profile/fullmoon.id/post/3meadfaulhk2s
1•todsacerdoti•5m ago•0 comments

Software development is undergoing a Renaissance in front of our eyes

https://twitter.com/gdb/status/2019566641491963946
1•tosh•5m ago•0 comments

Can you beat ensloppification? I made a quiz for Wikipedia's Signs of AI Writing

https://tryward.app/aiquiz
1•bennydog224•6m ago•1 comments

Spec-Driven Design with Kiro: Lessons from Seddle

https://medium.com/@dustin_44710/spec-driven-design-with-kiro-lessons-from-seddle-9320ef18a61f
1•nslog•7m ago•0 comments

Agents need good developer experience too

https://modal.com/blog/agents-devex
1•birdculture•8m ago•0 comments

The Dark Factory

https://twitter.com/i/status/2020161285376082326
1•Ozzie_osman•8m ago•0 comments

Free data transfer out to internet when moving out of AWS (2024)

https://aws.amazon.com/blogs/aws/free-data-transfer-out-to-internet-when-moving-out-of-aws/
1•tosh•9m ago•0 comments

Interop 2025: A Year of Convergence

https://webkit.org/blog/17808/interop-2025-review/
1•alwillis•10m ago•0 comments

Prejudice Against Leprosy

https://text.npr.org/g-s1-108321
1•hi41•11m ago•0 comments

Slint: Cross Platform UI Library

https://slint.dev/
1•Palmik•15m ago•0 comments

AI and Education: Generative AI and the Future of Critical Thinking

https://www.youtube.com/watch?v=k7PvscqGD24
1•nyc111•15m ago•0 comments

Maple Mono: Smooth your coding flow

https://font.subf.dev/en/
1•signa11•16m ago•0 comments

Moltbook isn't real but it can still hurt you

https://12gramsofcarbon.com/p/tech-things-moltbook-isnt-real-but
1•theahura•20m ago•0 comments

Take Back the Em Dash–and Your Voice

https://spin.atomicobject.com/take-back-em-dash/
1•ingve•20m ago•0 comments

Show HN: 289x speedup over MLP using Spectral Graphs

https://zenodo.org/login/?next=%2Fme%2Fuploads%3Fq%3D%26f%3Dshared_with_me%25253Afalse%26l%3Dlist...
1•andrespi•21m ago•0 comments

Teaching Mathematics

https://www.karlin.mff.cuni.cz/~spurny/doc/articles/arnold.htm
2•samuel246•24m ago•0 comments

3D Printed Microfluidic Multiplexing [video]

https://www.youtube.com/watch?v=VZ2ZcOzLnGg
2•downboots•24m ago•0 comments

Abstractions Are in the Eye of the Beholder

https://software.rajivprab.com/2019/08/29/abstractions-are-in-the-eye-of-the-beholder/
2•whack•25m ago•0 comments

Show HN: Routed Attention – 75-99% savings by routing between O(N) and O(N²)

https://zenodo.org/records/18518956
1•MikeBee•25m ago•0 comments

We didn't ask for this internet – Ezra Klein show [video]

https://www.youtube.com/shorts/ve02F0gyfjY
1•softwaredoug•26m ago•0 comments

The Real AI Talent War Is for Plumbers and Electricians

https://www.wired.com/story/why-there-arent-enough-electricians-and-plumbers-to-build-ai-data-cen...
2•geox•28m ago•0 comments

Show HN: MimiClaw, OpenClaw(Clawdbot)on $5 Chips

https://github.com/memovai/mimiclaw
1•ssslvky1•28m ago•0 comments

I Maintain My Blog in the Age of Agents

https://www.jerpint.io/blog/2026-02-07-how-i-maintain-my-blog-in-the-age-of-agents/
3•jerpint•29m ago•0 comments

The Fall of the Nerds

https://www.noahpinion.blog/p/the-fall-of-the-nerds
1•otoolep•30m ago•0 comments

Show HN: I'm 15 and built a free tool for reading ancient texts.

https://the-lexicon-project.netlify.app/
5•breadwithjam•33m ago•2 comments

How close is AI to taking my job?

https://epoch.ai/gradient-updates/how-close-is-ai-to-taking-my-job
1•cjbarber•34m ago•0 comments
Open in hackernews

Scientists use bacteria to turn plastic waste into paracetamol

https://www.theguardian.com/science/2025/jun/23/scientists-use-e-coli-bacteria-to-turn-plastic-waste-into-paracetamol-painkiller
52•bdev12345•7mo ago

Comments

doitLP•7mo ago
Paracetamol also known as Tylenol, Panadol and plain old acetaminophen
frogulis•7mo ago
Can't speak for the UK, but in Australia at least, "paracetamol" is the most commonly used non-brand name.
asplake•7mo ago
UK too.

Edit:

> Paracetamol is the Australian Approved Name and British Approved Name as well as the international nonproprietary name used by the WHO and in many other countries; acetaminophen is the United States Adopted Name and Japanese Accepted Name and also the name generally used in Canada, Venezuela, Colombia, and Iran. Both paracetamol and acetaminophen are contractions of chemical names for the compound.

Source: Wikipedia

cyberge99•7mo ago
Good to know the USA has something in common with IRAN. Perhaps start building from there.
ioma8•7mo ago
Paralen in Czech republic.
lawlessone•7mo ago
Could they put it in an mRNA vaccine so my body can break down plastic?
Arubis•7mo ago
The plastic in your body might be _less_ toxic than paracetamol.
lawlessone•7mo ago
Probably true , but my body can already remove the paracetamol
Arubis•7mo ago
That’d actually be a neat balance to figure out. Would the increased short-term liver toxicity be better over the long run than having bloodborne microplastics persist?
xattt•7mo ago
> … can already remove the paracetamol

In amounts less than 4 grams every 24 hours.

oharapj•7mo ago
Depending on how quickly the body would convert the plastic in this highly unrealistic hypothetical, that might work out just fine
colechristensen•7mo ago
The major part of this discovery was about something that e. coli already did on its own before genetic modification, so no not particularly. They might be able to engineer a symbiotic bacterium to live in your blood (there's a lot of doubt here), or more likely and less risky engineer a bacterium that consumed microplastics to live in your gut delivered as a probiotic or as a "vaccine" that you ate that would infect your existing microbiome.

And not an mRNA vaccine, those are kind of too simple and are mainly there to annoy the immune system. You would either use a virus to inject new genes into bacteria or insert plasmids into bacteria in a lab which would later be consumed.

aduwah•7mo ago
Geordie apocalypse is becoming reality

https://youtu.be/ctQXDpXTNZc?si=r52UCpxSN3fgjZfq

tux3•7mo ago
So, taking a non-expert look at the actual study, it looks like they first depolimerize PET into some acyl hydroxamate as a preparatory step.

Then it seems the big finding here is that this Lossen rearrangement, a regular non-biological chemical step, doesn't kill E. Coli. They derive PABA from that step.

And the E. Coli hasn't done anything yet, but since it's still alive, the cute trick is to turn PABA into APAP (acetaminophen). We already knew how to do that, but I suppose it demonstrates the point

Now what I don't get is what was wrong with running the Lossen step separately, and only feeding the output to the bacteria.

This article makes it sound like a miracle way to turn plastic into small molecules. They found that one of the step won't kill E. Coli. But it seems like all the steps were already possible before.

d4mi3n•7mo ago
I know nothing about this, but it seems like the kind of distinction that might make something easier/cheaper in practice. As in, do everything in a vat rather than needing to filter and pipe things around in a chemical facility.
6d6b73•7mo ago
Oh so now we can just ingest the bacteria and be pain free because of all the micro plastics in our body. Wonder what has more side effects?
melagonster•7mo ago
If blood contain enough bacteria, we have more problem should worry.
casey2•7mo ago
I wish there were 10 stories on how reducing plastic production would help clean up the waste problem for every innovation theater story like this