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Go 1.22, SQLite, and Next.js: The "Boring" Back End

https://mohammedeabdelaziz.github.io/articles/go-next-pt-2
1•mohammede•33s ago•0 comments

Laibach the Whistleblowers [video]

https://www.youtube.com/watch?v=c6Mx2mxpaCY
1•KnuthIsGod•1m ago•0 comments

I replaced the front page with AI slop and honestly it's an improvement

https://slop-news.pages.dev/slop-news
1•keepamovin•6m ago•1 comments

Economists vs. Technologists on AI

https://ideasindevelopment.substack.com/p/economists-vs-technologists-on-ai
1•econlmics•8m ago•0 comments

Life at the Edge

https://asadk.com/p/edge
1•tosh•14m ago•0 comments

RISC-V Vector Primer

https://github.com/simplex-micro/riscv-vector-primer/blob/main/index.md
2•oxxoxoxooo•17m ago•1 comments

Show HN: Invoxo – Invoicing with automatic EU VAT for cross-border services

2•InvoxoEU•18m ago•0 comments

A Tale of Two Standards, POSIX and Win32 (2005)

https://www.samba.org/samba/news/articles/low_point/tale_two_stds_os2.html
2•goranmoomin•22m ago•0 comments

Ask HN: Is the Downfall of SaaS Started?

3•throwaw12•23m ago•0 comments

Flirt: The Native Backend

https://blog.buenzli.dev/flirt-native-backend/
2•senekor•24m ago•0 comments

OpenAI's Latest Platform Targets Enterprise Customers

https://aibusiness.com/agentic-ai/openai-s-latest-platform-targets-enterprise-customers
1•myk-e•27m ago•0 comments

Goldman Sachs taps Anthropic's Claude to automate accounting, compliance roles

https://www.cnbc.com/2026/02/06/anthropic-goldman-sachs-ai-model-accounting.html
2•myk-e•30m ago•4 comments

Ai.com bought by Crypto.com founder for $70M in biggest-ever website name deal

https://www.ft.com/content/83488628-8dfd-4060-a7b0-71b1bb012785
1•1vuio0pswjnm7•30m ago•1 comments

Big Tech's AI Push Is Costing More Than the Moon Landing

https://www.wsj.com/tech/ai/ai-spending-tech-companies-compared-02b90046
3•1vuio0pswjnm7•32m ago•0 comments

The AI boom is causing shortages everywhere else

https://www.washingtonpost.com/technology/2026/02/07/ai-spending-economy-shortages/
2•1vuio0pswjnm7•34m ago•0 comments

Suno, AI Music, and the Bad Future [video]

https://www.youtube.com/watch?v=U8dcFhF0Dlk
1•askl•36m ago•2 comments

Ask HN: How are researchers using AlphaFold in 2026?

1•jocho12•39m ago•0 comments

Running the "Reflections on Trusting Trust" Compiler

https://spawn-queue.acm.org/doi/10.1145/3786614
1•devooops•44m ago•0 comments

Watermark API – $0.01/image, 10x cheaper than Cloudinary

https://api-production-caa8.up.railway.app/docs
1•lembergs•46m ago•1 comments

Now send your marketing campaigns directly from ChatGPT

https://www.mail-o-mail.com/
1•avallark•49m ago•1 comments

Queueing Theory v2: DORA metrics, queue-of-queues, chi-alpha-beta-sigma notation

https://github.com/joelparkerhenderson/queueing-theory
1•jph•1h ago•0 comments

Show HN: Hibana – choreography-first protocol safety for Rust

https://hibanaworks.dev/
5•o8vm•1h ago•1 comments

Haniri: A live autonomous world where AI agents survive or collapse

https://www.haniri.com
1•donangrey•1h ago•1 comments

GPT-5.3-Codex System Card [pdf]

https://cdn.openai.com/pdf/23eca107-a9b1-4d2c-b156-7deb4fbc697c/GPT-5-3-Codex-System-Card-02.pdf
1•tosh•1h ago•0 comments

Atlas: Manage your database schema as code

https://github.com/ariga/atlas
1•quectophoton•1h ago•0 comments

Geist Pixel

https://vercel.com/blog/introducing-geist-pixel
2•helloplanets•1h ago•0 comments

Show HN: MCP to get latest dependency package and tool versions

https://github.com/MShekow/package-version-check-mcp
1•mshekow•1h ago•0 comments

The better you get at something, the harder it becomes to do

https://seekingtrust.substack.com/p/improving-at-writing-made-me-almost
2•FinnLobsien•1h ago•0 comments

Show HN: WP Float – Archive WordPress blogs to free static hosting

https://wpfloat.netlify.app/
1•zizoulegrande•1h ago•0 comments

Show HN: I Hacked My Family's Meal Planning with an App

https://mealjar.app
1•melvinzammit•1h ago•0 comments
Open in hackernews

Newborns have elevated levels of a biomarker for Alzheimer's

https://medicalxpress.com/news/2025-06-newborns-elevated-biomarker-alzheimer.html
20•pseudolus•7mo ago

Comments

ProjectArcturis•7mo ago
One of the reasons Alzheimer's research has been so ineffective is that we don't know what physiological role tau and amyloid play in healthy brain function. Evolution didn't invent them so we would get Alzheimer's.

Seeing that tau is elevated during development suggests what that role might be. It also suggests that blocking tau entirely in adults might not have any important side effects.

Qem•7mo ago
> Seeing that tau is elevated during development suggests what that role might be.

I think this reinforces the hypothesis tau buildup and Alzheimer development are linked as side-effects of fighting infectious diseases. One thing newborns and seniors share is vulnerability to infections. Newborns because lack of previous exposure to pathogens. Seniors because of immune system senescence. Perhaps tau help protect newborns while they still lack acquired immunity to most common pathogens, and is reactivated back in some people by old age, as a Hail Mary effort to contain new or reactivating pathogens rampaging in face of failing defenses. That would explain the likely protective effect some vaccines, like shingles, have against Alzheimer.

Weryj•7mo ago
Would it be wild to suggest that the lower immunity means there’s more immune action further in the body /w waste?

I don’t have the expertise to validate the idea.

Qem•7mo ago
I have no idea.
ProjectArcturis•7mo ago
Yes, I think that's a reasonable guess. Far from proven, of course.
zingababba•7mo ago
Get them on caffeine, stat.