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Authors get bad reviews on Goodreads before review copies are even circulated

https://www.thebookseller.com/news/authors-hit-by-bad-reviews-on-goodreads-before-review-copies-are-even-circulated
1•ilamont•1m ago•0 comments

Building Castles in the Drive

https://idiallo.com/blog/building-castles-in-the-drive
1•foxfired•1m ago•0 comments

Why LLMs Can't Think

https://github.com/austengary33/austengary33.github.io/blob/main/blog/original-consciousness-formatted.md
1•austengary2•3m ago•0 comments

If you've lost your job, here's how to take care of yourself and your finances

https://apnews.com/article/layoffs-economy-finances-mental-health-46cba2de95050ec5e9091ef96c960be0
1•mooreds•4m ago•0 comments

Show HN: I built a graph based version of the crossword

https://wordlinks.up.railway.app/
1•imtoosly•4m ago•0 comments

Show HN: Releasepages.dev make release pages from Git commits

https://www.releasepages.dev/
1•cheeseblubber•8m ago•0 comments

Engine thrust incidents spur safety alert over biocides (2020)

https://www.flightglobal.com/safety/engine-thrust-incidents-spur-safety-alert-over-biocides/137638.article
1•gone35•8m ago•0 comments

Ghosting and 'breadcrumbing': the impact of bad behavior on dating apps

https://theconversation.com/ghosting-and-breadcrumbing-the-psychological-impact-of-our-bad-behaviour-on-dating-apps-258087
1•PaulHoule•8m ago•0 comments

Restoring Arctic Exceptionalism

https://quincyinst.org/events/restoring-arctic-exceptionalism/
1•Bluestein•9m ago•0 comments

Lateralized sleeping positions in domestic cats

https://www.cell.com/current-biology/fulltext/S0960-9822(25)00507-X
1•carabiner•9m ago•0 comments

Las Vegas Through Landsat 7's Eyes (2024)

https://www.usgs.gov/media/before-after/las-vegas-through-landsat-7s-eyes
1•gnabgib•11m ago•0 comments

Tech in Iran-Israel conflict: internet blackout, crypto burns and camera spying

https://www.theguardian.com/technology/2025/jun/23/iran-israel-internet-blackout-crypto-home-camera-spying
2•Bluestein•12m ago•0 comments

Show HN: Natively – AI mobile app builder (iOS and Android)

https://natively.dev
1•hamedmp•17m ago•0 comments

OpenAI Is Ruthless [video]

https://www.youtube.com/watch?v=nFoXCLi8FCc
2•data_spy•17m ago•1 comments

The consequences of Starbucks on startup culture in neighborhoods

https://thetreeoflife.cc/demo
1•WasimBhai•20m ago•0 comments

The Ant Mill: How theoretical high-energy physics descended into groupthink

https://jespergrimstrup.substack.com/p/the-ant-mill-how-theoretical-high
2•Luc•21m ago•1 comments

National Archives to restrict public access starting July 7

https://www.archives.gov/college-park
2•LastTrain•24m ago•0 comments

Mexico is now Chinas No. 1 car export market

https://mexiconewsdaily.com/business/company-owned-byd-ship-vehicles-mexican-ports/
1•ilamont•25m ago•0 comments

Python Tools Are Quickly Adopting the New pylock.toml Standard

https://socket.dev/blog/pylock-toml-standard-adoption
1•divbzero•26m ago•0 comments

The Discovery Engine (automated system for scientific discovery)

https://zenodo.org/records/15693353
1•talos•27m ago•0 comments

Show HN: Vybetr – Hire AI app developers using tools like Lovable, Bolt and more

https://vybetr.com
4•zicxor•29m ago•0 comments

Using Lxcfs Together with Podman

https://www.die-welt.net/2025/06/using-lxcfs-together-with-podman/
1•todsacerdoti•30m ago•0 comments

Lessons from LangChain and Slack and MCP Integration

https://medium.com/@valliappanr/what-i-learned-integrating-langchain-with-slack-via-mcp-and-why-ai-code-isnt-enough-3e72248b96b1
1•valliappanr•32m ago•1 comments

Use of ch unit considered inappropriate (in certain circumstances)

https://clagnut.com/blog/2432
1•mikehall314•33m ago•0 comments

Brit Watchdog Cracks Down on Data Collection by Smart TVs, Speakers, Air Fryers

https://www.theguardian.com/technology/2025/jun/16/air-fryers-smart-tv-speakers-user-data-privacy-ico
2•m463•34m ago•1 comments

Thoughts on the AI 2027 Discourse

https://dynomight.substack.com/p/ai2027
2•paulpauper•35m ago•0 comments

Childhood and Education #10: Behaviors

https://thezvi.substack.com/p/childhood-and-education-10-behaviors
1•paulpauper•35m ago•0 comments

When Can I Stop Listening to My Enemy's Points?

https://substack.com/home/post/p-166684398
1•paulpauper•39m ago•0 comments

Show HN: Letter Lockbox – A word game I built over the weekend with Claude Code

https://www.letterlockbox.com
1•christensen143•39m ago•0 comments

Programmers and Their Monospace Blogs

https://lambdaland.org/posts/2025-06-24_reading_blogs/
1•ashton314•39m ago•0 comments
Open in hackernews

Newborns have elevated levels of a biomarker for Alzheimer's

https://medicalxpress.com/news/2025-06-newborns-elevated-biomarker-alzheimer.html
19•pseudolus•8h ago

Comments

ProjectArcturis•7h ago
One of the reasons Alzheimer's research has been so ineffective is that we don't know what physiological role tau and amyloid play in healthy brain function. Evolution didn't invent them so we would get Alzheimer's.

Seeing that tau is elevated during development suggests what that role might be. It also suggests that blocking tau entirely in adults might not have any important side effects.

Qem•6h ago
> Seeing that tau is elevated during development suggests what that role might be.

I think this reinforces the hypothesis tau buildup and Alzheimer development are linked as side-effects of fighting infectious diseases. One thing newborns and seniors share is vulnerability to infections. Newborns because lack of previous exposure to pathogens. Seniors because of immune system senescence. Perhaps tau help protect newborns while they still lack acquired immunity to most common pathogens, and is reactivated back in some people by old age, as a Hail Mary effort to contain new or reactivating pathogens rampaging in face of failing defenses. That would explain the likely protective effect some vaccines, like shingles, have against Alzheimer.

Weryj•5h ago
Would it be wild to suggest that the lower immunity means there’s more immune action further in the body /w waste?

I don’t have the expertise to validate the idea.

Qem•4h ago
I have no idea.