frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Open in hackernews

The Big Vitamin D Mistake (2017)

https://pmc.ncbi.nlm.nih.gov/articles/PMC5541280/
24•busymom0•6mo ago

Comments

gmane•6mo ago
This paper cites 10 other papers, two of which are essentially the same paper. The author also has additional papers claiming that Vitamin D helps prevent COVID mortality using a "ecological integrative approach." His papers also all seem to be lacking concrete meta-analysis and discussion of other approaches and clinical data.

Seems... like a quack.

its-summertime•6mo ago
Do you have a link to said COVID paper? And which two papers did you consider the same?
gmane•6mo ago
Here you go: https://pubmed.ncbi.nlm.nih.gov/34079693/

Edit: You can also click on his name in the original post (or the link above) and see all the papers in pubmed authored by him.

Edit 2: These two papers:

Veugelers PJ, Ekwaru JP. A statistical error in the estimation of the recommended dietary allowance for vitamin D. Nutrients. 2014;6(10):4472–4475. - PMC - PubMed Veugelers PJ, Ekwaru JP. A statistical error in the estimation of the recommended dietary allowance for vitamin D. Nutrients. 2014;6(10):4472–4475. - PMC - PubMed

and

Heaney R, Garland C, Baggerly C, French C, Gorham E. Letter to Veugelers, P.J. and Ekwaru, J.P., A statistical error in the estimation of the recommended dietary allowance for vitamin D. Nutrients 2014, 6, 4472-4475; doi:10.3390/nu6104472. Nutrients. 2015;7(3):1688–1690. - PMC - PubMed

its-summertime•6mo ago
From what I can tell, the "ecological integrative approach" is referring to the approach used in the research of that paper, not on how Vitamin D acts in relation to COVID

> Following an ecological integrative approach, we examined the associations between published representative and standardized European population vitamin D data and the Worldometer COVID-19 data at two completely different time points of the first wave of this pandemic.

and

> Thus, a major limitation of our ecological approach is that we had to rely on published - but perhaps not always completely representative - data on the vitamin D status of the populations in Europe.

gmane•6mo ago
Right, I was criticizing the approach. Edit: specifically the fact that the paper has no discussion of how the meta-analysis data was prepared, processed, or how they made sure it was complete.
its-summertime•6mo ago
Of the papers, The second one is a response to the first one. Citing both parts of a discussion seems really normal.
gmane•6mo ago
I would agree with you if this paper was citing... more papers. Since there are so few and one of the citations is a concurrence with the paper with actual data work, then it harms this paper.

Either the author didn't do a literature review before publishing, isn't well versed in the field, or chose not to cite works which may not agree with their results. Neither of which reflects well on the author.

Supermancho•6mo ago
Since the pandemic, there was certainly noise about Vitamin D deficiency and COVID-19 death correlation that the NIH decried as unsubstantiated. Fair enough. Since then, quite a bit of data has been collected.

There are a few hundred PHDs^1 that agree that Vitamin D deficiency increases COVID 19 mortality (nowhere is prevention mentioned) in the US, with no EU overlap that I could see from casual review.

Maybe I'm taking sides here, but I think the data is supported, even if the NIH papers are flawed. Funding what many people assume to be a null hypothesis, is not popular so there may never be research that is convincing, for most.

^1 The signatories are not a comprehensive list, but one list among others: https://www.onedaymd.com/2020/12/vitamin-D-COVID19.html

seec•6mo ago
It's probably just a confounding variable.

Having more Vitamin D probably means that you are getting more outside activity and/or have a better diet. Both things have a protective effect against things like Covid in the way of better cardio and immune system.

So, I would say that the link is very weak at best and probably not related to vitamin D directly.

criley2•6mo ago
I had ChatGPT o3 judge the paper, interesting results https://chatgpt.com/s/t_68876055374c81918960920665a4c87b

"The Big Vitamin D Mistake is a concise advocacy editorial, not a definitive study. Its central thesis—that we all need ~10× more vitamin D than current RDAs—is not supported by subsequent large randomized trials or by regulatory reviews. Use it, if at all, as a conversation starter about DRI methodology, not as a basis for clinical dosing."

aBioGuy•6mo ago
I would like to point out (as I have seen this confused by many non-scientists) that the NIH (National Library of Medicine) provides a service called "PubMed" which collates peer-reviewed (and many pre-print) scientific papers into one database / website. This particular paper (like 99% of the papers on PubMed) was not published by a NIH scientist or by the NIH itself.
its-summertime•6mo ago
The crux of the title is from the following

> In Finland, the recommendation for daily vitamin D supplementation was gradually reduced from 4000-5000 IU in 1964 to 400 IU in 1992.

And from https://pmc.ncbi.nlm.nih.gov/articles/PMC4210929/ which has

> The Institute of Medicine (IOM) issues dietary recommendations on the request of the U.S. and Canadian governments. One of these recommendations is the Recommended Dietary Allowance (RDA). The RDA is the nutrient intake considered to be sufficient to meet the requirements of 97.5% of healthy individuals. The RDA for vitamin D is 600 IU per day for individuals 1 to 70 years of age and is assumed to achieve serum 25-hydroxyvitamin D (25(OH)D) levels of 50 nmol/L or more in 97.5% of healthy individuals.

DigiEggz•6mo ago
Off topic, but I know someone who was able to narrow down the source of their kidney stones to vitamin D supplement pills, and they were taking them at suggested doses. Wanted to put that here in case it helps someone avoid agony.
ChrisArchitect•6mo ago
(2017)

Some discussion then: https://news.ycombinator.com/item?id=15867918

Dorsey's Block cutting up to 10% of staff

https://www.reuters.com/business/dorseys-block-cutting-up-10-staff-bloomberg-news-reports-2026-02...
1•dev_tty01•2m ago•0 comments

Show HN: Freenet Lives – Real-Time Decentralized Apps at Scale [video]

https://www.youtube.com/watch?v=3SxNBz1VTE0
1•sanity•3m ago•1 comments

In the AI age, 'slow and steady' doesn't win

https://www.semafor.com/article/01/30/2026/in-the-ai-age-slow-and-steady-is-on-the-outs
1•mooreds•11m ago•1 comments

Administration won't let student deported to Honduras return

https://www.reuters.com/world/us/trump-administration-wont-let-student-deported-honduras-return-2...
1•petethomas•11m ago•0 comments

How were the NIST ECDSA curve parameters generated? (2023)

https://saweis.net/posts/nist-curve-seed-origins.html
1•mooreds•12m ago•0 comments

AI, networks and Mechanical Turks (2025)

https://www.ben-evans.com/benedictevans/2025/11/23/ai-networks-and-mechanical-turks
1•mooreds•12m ago•0 comments

Goto Considered Awesome [video]

https://www.youtube.com/watch?v=1UKVEUGEk6Y
1•linkdd•14m ago•0 comments

Show HN: I Built a Free AI LinkedIn Carousel Generator

https://carousel-ai.intellisell.ai/
1•troyethaniel•16m ago•0 comments

Implementing Auto Tiling with Just 5 Tiles

https://www.kyledunbar.dev/2026/02/05/Implementing-auto-tiling-with-just-5-tiles.html
1•todsacerdoti•17m ago•0 comments

Open Challange (Get all Universities involved

https://x.com/i/grok/share/3513b9001b8445e49e4795c93bcb1855
1•rwilliamspbgops•18m ago•0 comments

Apple Tried to Tamper Proof AirTag 2 Speakers – I Broke It [video]

https://www.youtube.com/watch?v=QLK6ixQpQsQ
2•gnabgib•20m ago•0 comments

Show HN: Isolating AI-generated code from human code | Vibe as a Code

https://www.npmjs.com/package/@gace/vaac
1•bstrama•21m ago•0 comments

Show HN: More beautiful and usable Hacker News

https://twitter.com/shivamhwp/status/2020125417995436090
3•shivamhwp•21m ago•0 comments

Toledo Derailment Rescue [video]

https://www.youtube.com/watch?v=wPHh5yHxkfU
1•samsolomon•23m ago•0 comments

War Department Cuts Ties with Harvard University

https://www.war.gov/News/News-Stories/Article/Article/4399812/war-department-cuts-ties-with-harva...
6•geox•27m ago•0 comments

Show HN: LocalGPT – A local-first AI assistant in Rust with persistent memory

https://github.com/localgpt-app/localgpt
1•yi_wang•28m ago•0 comments

A Bid-Based NFT Advertising Grid

https://bidsabillion.com/
1•chainbuilder•32m ago•1 comments

AI readability score for your documentation

https://docsalot.dev/tools/docsagent-score
1•fazkan•39m ago•0 comments

NASA Study: Non-Biologic Processes Don't Explain Mars Organics

https://science.nasa.gov/blogs/science-news/2026/02/06/nasa-study-non-biologic-processes-dont-ful...
2•bediger4000•42m ago•2 comments

I inhaled traffic fumes to find out where air pollution goes in my body

https://www.bbc.com/news/articles/c74w48d8epgo
2•dabinat•43m ago•0 comments

X said it would give $1M to a user who had previously shared racist posts

https://www.nbcnews.com/tech/internet/x-pays-1-million-prize-creator-history-racist-posts-rcna257768
4•doener•45m ago•1 comments

155M US land parcel boundaries

https://www.kaggle.com/datasets/landrecordsus/us-parcel-layer
2•tjwebbnorfolk•50m ago•0 comments

Private Inference

https://confer.to/blog/2026/01/private-inference/
2•jbegley•53m ago•1 comments

Font Rendering from First Principles

https://mccloskeybr.com/articles/font_rendering.html
1•krapp•56m ago•0 comments

Show HN: Seedance 2.0 AI video generator for creators and ecommerce

https://seedance-2.net
1•dallen97•1h ago•0 comments

Wally: A fun, reliable voice assistant in the shape of a penguin

https://github.com/JLW-7/Wally
2•PaulHoule•1h ago•0 comments

Rewriting Pycparser with the Help of an LLM

https://eli.thegreenplace.net/2026/rewriting-pycparser-with-the-help-of-an-llm/
2•y1n0•1h ago•0 comments

Lobsters Vibecoding Challenge

https://gist.github.com/MostAwesomeDude/bb8cbfd005a33f5dd262d1f20a63a693
2•tolerance•1h ago•0 comments

E-Commerce vs. Social Commerce

https://moondala.one/
1•HamoodBahzar•1h ago•1 comments

Avoiding Modern C++ – Anton Mikhailov [video]

https://www.youtube.com/watch?v=ShSGHb65f3M
2•linkdd•1h ago•0 comments