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The next frontier in weight-loss drugs: one-time gene therapy

https://www.washingtonpost.com/health/2026/01/24/fractyl-glp1-gene-therapy/
1•bookofjoe•2m ago•1 comments

At Age 25, Wikipedia Refuses to Evolve

https://spectrum.ieee.org/wikipedia-at-25
1•asdefghyk•4m ago•2 comments

Show HN: ReviewReact – AI review responses inside Google Maps ($19/mo)

https://reviewreact.com
1•sara_builds•5m ago•0 comments

Why AlphaTensor Failed at 3x3 Matrix Multiplication: The Anchor Barrier

https://zenodo.org/records/18514533
1•DarenWatson•6m ago•0 comments

Ask HN: How much of your token use is fixing the bugs Claude Code causes?

1•laurex•9m ago•0 comments

Show HN: Agents – Sync MCP Configs Across Claude, Cursor, Codex Automatically

https://github.com/amtiYo/agents
1•amtiyo•10m ago•0 comments

Hello

1•otrebladih•12m ago•0 comments

FSD helped save my father's life during a heart attack

https://twitter.com/JJackBrandt/status/2019852423980875794
2•blacktulip•14m ago•0 comments

Show HN: Writtte – Draft and publish articles without reformatting, anywhere

https://writtte.xyz
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Portuguese icon (FROM A CAN) makes a simple meal (Canned Fish Files) [video]

https://www.youtube.com/watch?v=e9FUdOfp8ME
1•zeristor•18m ago•0 comments

Brookhaven Lab's RHIC Concludes 25-Year Run with Final Collisions

https://www.hpcwire.com/off-the-wire/brookhaven-labs-rhic-concludes-25-year-run-with-final-collis...
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Transcribe your aunts post cards with Gemini 3 Pro

https://leserli.ch/ocr/
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.72% Variance Lance

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ReKindle – web-based operating system designed specifically for E-ink devices

https://rekindle.ink
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Encrypt It

https://encryptitalready.org/
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NextMatch – 5-minute video speed dating to reduce ghosting

https://nextmatchdating.netlify.app/
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Personalizing esketamine treatment in TRD and TRBD

https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1736114
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SpaceKit.xyz – a browser‑native VM for decentralized compute

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NotebookLM: The AI that only learns from you

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Show HN: An open-source starter kit for developing with Postgres and ClickHouse

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Game Boy Advance d-pad capacitor measurements

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South Korean crypto firm accidentally sends $44B in bitcoins to users

https://www.reuters.com/world/asia-pacific/crypto-firm-accidentally-sends-44-billion-bitcoins-use...
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Apache Poison Fountain

https://gist.github.com/jwakely/a511a5cab5eb36d088ecd1659fcee1d5
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Web.whatsapp.com appears to be having issues syncing and sending messages

http://web.whatsapp.com
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Google in Your Terminal

https://gogcli.sh/
1•johlo•35m ago•0 comments

Shannon: Claude Code for Pen Testing: #1 on Github today

https://github.com/KeygraphHQ/shannon
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Anthropic: Latest Claude model finds more than 500 vulnerabilities

https://www.scworld.com/news/anthropic-latest-claude-model-finds-more-than-500-vulnerabilities
2•Bender•40m ago•0 comments

Brooklyn cemetery plans human composting option, stirring interest and debate

https://www.cbsnews.com/newyork/news/brooklyn-green-wood-cemetery-human-composting/
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Why the 'Strivers' Are Right

https://greyenlightenment.com/2026/02/03/the-strivers-were-right-all-along/
1•paulpauper•42m ago•0 comments

Brain Dumps as a Literary Form

https://davegriffith.substack.com/p/brain-dumps-as-a-literary-form
1•gmays•42m ago•0 comments
Open in hackernews

The world has a running Rational R1000/400 computer again (2019)

https://datamuseum.dk/wiki/Rational/R1000s400/Logbook/2019#2019-10-28
53•MaxLeiter•5mo ago

Comments

aaron_m04•5mo ago
This link doesn't really tell me anything.
joshu•5mo ago
https://en.wikipedia.org/wiki/Rational_R1000

Appears to be an ADA-based workstation?

Is this the same Rational as Rational ClearCase etc as acquired by IBM back in the day? Crazy

palmotea•5mo ago
> Is this the same Rational as Rational ClearCase etc as acquired by IBM back in the day? Crazy

Looks like it:

https://en.wikipedia.org/wiki/Rational_Software

> Rational Machines is an enterprise founded by Paul Levy and Mike Devlin in 1981 to provide tools to expand the use of modern software engineering practices, particularly explicit modular architecture and iterative development. It changed its name in 1994 to Rational Software, and was sold for US$2.1 billion (equivalent to current US$3.59 billion[1]) to IBM on February 21,[2] 2003.

phkamp•5mo ago
This is not only where ClearCase comes from, this is where "The Booch Method", UML, and the software for the Space Shuttle, The International Space Station, EuroControl (= pan-european air traffic control) and the F-22 fighter jet comes from. (Plus who knows how much other militarg hardware...)

It is a truly astonishing software development environment which with a a single key-press can answer questions like "what other code is affected if I change the default value of a parameter to this function". (Think about that one for a second!)

anticodon•5mo ago
ClearCase is the worst VCS software that I ever used in my life. Maybe in the beginning of 90s it was better than existing alternatives, but I was using it well in 2000s, and it was horrible experience compared to already existing Git, Mercurial and even Subversion.

And if you add the cost (around $5000 per workplace), it becomes even less understandable.

It also required a designated CC admin or several admins.

phkamp•5mo ago
I'm personally no fan of ClearCase myself, it's far to rigid for my taste.

But if I were the pilot in an F-22 or the Space Shuttle, I probably would want it to be even more rigid :-)

It's important to keep in mind the context of this machine and the software it was used to develop.

joshu•5mo ago
Ada, not ADA
phkamp•5mo ago
The R1000 is a micro-coded computer built from approx 5k TTL functions, with an instruction set consisting of Ada Primitives like "Define a type for a variant structure with 3 variants, you'll get the details later".

It processes 64bit data and 64 bit type information about that data in parallel, in hardware.

It is also object oriented in hardware, there is no linear address space or VM-tree,

Three left in the world, plus one mostly empty chassis.

My Covid19 project was writing a software emulation of it, starting from 400 pages of schematics, because the instruction set is not documented.

And yes, I'm way behind on documenting it, because I also have a life :-)

shawn_w•5mo ago
So basically an AdaMachine?
quietbritishjim•5mo ago
> instruction set consisting of Ada Primitives like "Define a type for a variant structure with 3 variants, you'll get the details later".

Wow, it's hard for me to imagine a CPU with such high level instructions. Were these per-process, like virtual memory on a modern processor? Or was there only expected to be one executable running on the machine at a time?

> My Covid19 project was writing a software emulation of it,

Where did you get to? Do you have a link?

TheOtherHobbes•5mo ago
The microcoding means you have fairly standard CPU hardware - an ALU, some registers, memory ports, and so on - and the microcode sequences it to emulate the ISA.

So it's not that the ADA primitives were baked directly into TTL.

It's somewhat related to the Itanium model where the compiler generates a Very Long Instruction Word.

Microcode is a standard way of implementing CISC, but this machine took it further than usual.

phkamp•5mo ago
"fairly standard" is a bit of an understatement in this particular case.

The machine actually has both an ALU as we know it, called the "VAL" board, but it also has a second unit, which runs in parallel on the "TYP" board, which does checks and operations on the data types of the data on the VAL board.

That means that the compiler can just emit a "ADD" instruction, and leave it to the microcode to figure out if it is adding two floating point numbers, two integers or a floating-point plus an integer and if the numeric type has a range, the result will be checked to fit inside that range.

So the comparison to the Itanic is not helpful. Itanic was a pretty standard CPU which forced a lot of constraints and complexity into the compiler.

The R1000 does the opposite: The compiler gets to emit code which operates on the types as the Ada language defines and knows them, and the hardware+microcode translates that into action.

Grady Booch donated some internal documents to us, and they contain a couple of references to "Incredibly Complex Instruction Set Computer" and they're not half wrong about that.

neilv•5mo ago
I knew Rational did Ada (and later acquired awesome products from Atria and Pure), but didn't know they had their own workstation hardware in the '80s.

And it had a nice portrait orientation monitor like some early Xerox workstations (the PARC ones like Alto, and the fancy word processors like 850 and 860 IPS).

Later, starting as a teen, I was working for Cadre, a competitor of Rational on workstation software engineering tools. The company started with Apollo Domain workstations (not rolled their own), and, by the time I joined, had added Sun, HP, IBM, DEC, and MS Windows.

The Cadre site I started at (a spinoff of Tektronix, which did high-end hardware in-circuit emulators with CASE workstation frontends) was practically across the street in the OGI science park from Verdix, which, a bit like Rational, did Ada development tools and related neat systems work like (IIRC) secure compartmentalized workstation technology.

It was an exciting time in computers, and in hindsight, as a kid I saw engineers picking up and applying broader mixes of skills than we usually do in today's fairly rigid skills silos.

v9v•5mo ago
They have an emulator here: https://github.com/Datamuseum-DK/R1000.Emulator2

Notably it needs KiCad to run and takes ~140 hours to boot.

Seems like the reason for KiCad and the slow operation is that the emulation occurs at a really low level, and they've written a program to digitize all of the computer's schematics and convert them into netlists (which is then converted into systemC components for the emulator): https://github.com/Datamuseum-DK/R1000.HwDoc

a video explaining the process?: https://www.youtube.com/watch?v=oMRTr0bPuOA

phkamp•5mo ago
Apologies for outdated information there...

On an Apple M2 CPU it runs around the same speed as the real hardware now.

(The first version based on the unaltered hardware schematics ran 4000 times slower than real hardware, it's been quite a journey :-)

shrubble•5mo ago
I’d be curious if this was similar to the Western Digital Pascal chips: https://en.wikipedia.org/wiki/Pascal_MicroEngine

Supposedly the first verification of the first Ada compiler was done on a system made with the Pascal MicroEngine.

MaxLeiter•5mo ago
It doesn’t answer your question but I came across this yesterday doing some research on the R1000 (which is why I came across the OP). You might find it interesting:

Ada Compiler Validation Summary Report: Rational Environment

https://apps.dtic.mil/sti/tr/pdf/ADA157830.pdf