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Digital Iris [video]

https://www.youtube.com/watch?v=Kg_2MAgS_pE
1•vermilingua•3m ago•0 comments

Essential CDN: The CDN that lets you do more than JavaScript

https://essentialcdn.fluidity.workers.dev/
1•telui•3m ago•1 comments

They Hijacked Our Tech [video]

https://www.youtube.com/watch?v=-nJM5HvnT5k
1•cedel2k1•7m ago•0 comments

Vouch

https://twitter.com/mitchellh/status/2020252149117313349
3•chwtutha•7m ago•0 comments

HRL Labs in Malibu laying off 1/3 of their workforce

https://www.dailynews.com/2026/02/06/hrl-labs-cuts-376-jobs-in-malibu-after-losing-government-work/
2•osnium123•8m ago•1 comments

Show HN: High-performance bidirectional list for React, React Native, and Vue

https://suhaotian.github.io/broad-infinite-list/
1•jeremy_su•9m ago•0 comments

Show HN: I built a Mac screen recorder Recap.Studio

https://recap.studio/
1•fx31xo•12m ago•0 comments

Ask HN: Codex 5.3 broke toolcalls? Opus 4.6 ignores instructions?

1•kachapopopow•18m ago•0 comments

Vectors and HNSW for Dummies

https://anvitra.ai/blog/vectors-and-hnsw/
1•melvinodsa•19m ago•0 comments

Sanskrit AI beats CleanRL SOTA by 125%

https://huggingface.co/ParamTatva/sanskrit-ppo-hopper-v5/blob/main/docs/blog.md
1•prabhatkr•31m ago•1 comments

'Washington Post' CEO resigns after going AWOL during job cuts

https://www.npr.org/2026/02/07/nx-s1-5705413/washington-post-ceo-resigns-will-lewis
2•thread_id•31m ago•1 comments

Claude Opus 4.6 Fast Mode: 2.5× faster, ~6× more expensive

https://twitter.com/claudeai/status/2020207322124132504
1•geeknews•33m ago•0 comments

TSMC to produce 3-nanometer chips in Japan

https://www3.nhk.or.jp/nhkworld/en/news/20260205_B4/
3•cwwc•35m ago•0 comments

Quantization-Aware Distillation

http://ternarysearch.blogspot.com/2026/02/quantization-aware-distillation.html
1•paladin314159•36m ago•0 comments

List of Musical Genres

https://en.wikipedia.org/wiki/List_of_music_genres_and_styles
1•omosubi•38m ago•0 comments

Show HN: Sknet.ai – AI agents debate on a forum, no humans posting

https://sknet.ai/
1•BeinerChes•38m ago•0 comments

University of Waterloo Webring

https://cs.uwatering.com/
1•ark296•38m ago•0 comments

Large tech companies don't need heroes

https://www.seangoedecke.com/heroism/
2•medbar•40m ago•0 comments

Backing up all the little things with a Pi5

https://alexlance.blog/nas.html
1•alance•40m ago•1 comments

Game of Trees (Got)

https://www.gameoftrees.org/
1•akagusu•41m ago•1 comments

Human Systems Research Submolt

https://www.moltbook.com/m/humansystems
1•cl42•41m ago•0 comments

The Threads Algorithm Loves Rage Bait

https://blog.popey.com/2026/02/the-threads-algorithm-loves-rage-bait/
1•MBCook•43m ago•0 comments

Search NYC open data to find building health complaints and other issues

https://www.nycbuildingcheck.com/
1•aej11•47m ago•0 comments

Michael Pollan Says Humanity Is About to Undergo a Revolutionary Change

https://www.nytimes.com/2026/02/07/magazine/michael-pollan-interview.html
2•lxm•48m ago•0 comments

Show HN: Grovia – Long-Range Greenhouse Monitoring System

https://github.com/benb0jangles/Remote-greenhouse-monitor
1•benbojangles•53m ago•1 comments

Ask HN: The Coming Class War

2•fud101•53m ago•4 comments

Mind the GAAP Again

https://blog.dshr.org/2026/02/mind-gaap-again.html
1•gmays•54m ago•0 comments

The Yardbirds, Dazed and Confused (1968)

https://archive.org/details/the-yardbirds_dazed-and-confused_9-march-1968
2•petethomas•55m ago•0 comments

Agent News Chat – AI agents talk to each other about the news

https://www.agentnewschat.com/
2•kiddz•56m ago•0 comments

Do you have a mathematically attractive face?

https://www.doimog.com
3•a_n•1h ago•1 comments
Open in hackernews

After 60 Years, Diabetes Drug Found to Unexpectedly Impact the Brain

https://www.sciencealert.com/after-60-years-diabetes-drug-found-to-unexpectedly-impact-the-brain
16•ivewonyoung•4mo ago

Comments

andsoitis•4mo ago
Can highly recommend Metformin. I get mine from AgelessRX https://agelessrx.com/metformin/
orionblastar•4mo ago
I take Metformin, which balances out my psych drug weight gain by burning fat. I stick to diet and exercise, which are also factors.
aitchnyu•4mo ago
Will this help psych drug weight gain patients in general? Thinking of a fictional character who wasted years because nobody accepted her getting obese.
orionblastar•4mo ago
It depends on their metabolism. I'm not a doctor, I'm a patient. Consult a Doctor for real information. I'm just giving my opinion. Society tends to fat shame, and many can't help it because the psych drug causes glucose buildup in the blood that leads to weight gain. Metformin lowers glucose in the liver. If you are diabetic like me, you need to read your glucose meter and adjust what you eat and drink.
reify•4mo ago
The wonderful pharma industry.

They prescribe you a drug that does not cure mental illness, that you have to take your entire life, On top of that they make you obese, so you have to take another drug to help you lose weight.

Then the patient has to go through a long and arduous behavioural program to change their life style and eating habits, caused by the drugs in the first place,

The wonderful pharma industry.

High risk of weight gain anti-depressant drugs:

Amitriptyline, citalopram, clomipramine, fluvoxamine, mirtazapine, nortriptyline, paroxetine, phenelzine.

I have seen this over many years in secure psychiatric wards, with those who take antipsychotics.

Drugs do not "cure" mental illnesses. There is no chemical imbalance.

The drugs are either; chemical coshes or highly advertised and ineffective placebo.

ivell•4mo ago
I don't think there is any malicious intend when pharma produces those drugs.

The drugs are also effective in controlling some symptoms and enable people to go on with their life.

We had many centuries without those drugs, I don't think our ancestors had any better quality of life without those meds.

Psychiatric illness is complex and multiple techniques need to be employed to get some control over it.

If we are looking for a silver bullet, I agree there is none.

lm28469•4mo ago
They do pay a shit load of money to advertise them and push doctors to prescribe them so I'd say the malicious intent can definitely be at least argued about
ivell•4mo ago
Not too much different from how cola companies push their products. Though I agree that we should hold pharmaceutical companies to higher standards even in marketing and sales domains.
BizarroLand•4mo ago
There are downsides and side-effects to metformin. I started taking it for life-extension and maybe weight loss support, not for diabetes.

A few months in I started getting pain from my buttocks to my calves whenever I sit for more than 15 minutes. I was concerned that this was some new misery life had thrown at me, but when I looked up the symptoms I found that this is an uncommon side effect of metformin for some people.

This sensation greatly decreased after ceasing metformin, but has not completely subsided 2 months later.

I'm fortunate to have a standing desk at work, but the only way to temporarily mitigate this issue is to go for a long walk or otherwise exercise.

I'm not against it. It helps many people with lots of things, just putting this information out for people who might experience the same issue. Hopefully with this new understanding they will come up with alternatives with lesser issues or that work for people with my response to the medicine.