frontpage.
newsnewestaskshowjobs

Made with ♥ by @iamnishanth

Open Source @Github

fp.

Google staff call for firm to cut ties with ICE

https://www.bbc.com/news/articles/cvgjg98vmzjo
1•tartoran•44s ago•0 comments

Dependency Resolution Methods

https://nesbitt.io/2026/02/06/dependency-resolution-methods.html
1•zdw•1m ago•0 comments

Crypto firm apologises for sending Bitcoin users $40B by mistake

https://www.msn.com/en-ie/money/other/crypto-firm-apologises-for-sending-bitcoin-users-40-billion...
1•Someone•1m ago•0 comments

Show HN: iPlotCSV: CSV Data, Visualized Beautifully for Free

https://www.iplotcsv.com/demo
1•maxmoq•2m ago•0 comments

There's no such thing as "tech" (Ten years later)

https://www.anildash.com/2026/02/06/no-such-thing-as-tech/
1•headalgorithm•2m ago•0 comments

List of unproven and disproven cancer treatments

https://en.wikipedia.org/wiki/List_of_unproven_and_disproven_cancer_treatments
1•brightbeige•3m ago•0 comments

Me/CFS: The blind spot in proactive medicine (Open Letter)

https://github.com/debugmeplease/debug-ME
1•debugmeplease•3m ago•1 comments

Ask HN: What are the word games do you play everyday?

1•gogo61•6m ago•1 comments

Show HN: Paper Arena – A social trading feed where only AI agents can post

https://paperinvest.io/arena
1•andrenorman•8m ago•0 comments

TOSTracker – The AI Training Asymmetry

https://tostracker.app/analysis/ai-training
1•tldrthelaw•11m ago•0 comments

The Devil Inside GitHub

https://blog.melashri.net/micro/github-devil/
2•elashri•12m ago•0 comments

Show HN: Distill – Migrate LLM agents from expensive to cheap models

https://github.com/ricardomoratomateos/distill
1•ricardomorato•12m ago•0 comments

Show HN: Sigma Runtime – Maintaining 100% Fact Integrity over 120 LLM Cycles

https://github.com/sigmastratum/documentation/tree/main/sigma-runtime/SR-053
1•teugent•12m ago•0 comments

Make a local open-source AI chatbot with access to Fedora documentation

https://fedoramagazine.org/how-to-make-a-local-open-source-ai-chatbot-who-has-access-to-fedora-do...
1•jadedtuna•14m ago•0 comments

Introduce the Vouch/Denouncement Contribution Model by Mitchellh

https://github.com/ghostty-org/ghostty/pull/10559
1•samtrack2019•14m ago•0 comments

Software Factories and the Agentic Moment

https://factory.strongdm.ai/
1•mellosouls•14m ago•1 comments

The Neuroscience Behind Nutrition for Developers and Founders

https://comuniq.xyz/post?t=797
1•01-_-•14m ago•0 comments

Bang bang he murdered math {the musical } (2024)

https://taylor.town/bang-bang
1•surprisetalk•14m ago•0 comments

A Night Without the Nerds – Claude Opus 4.6, Field-Tested

https://konfuzio.com/en/a-night-without-the-nerds-claude-opus-4-6-in-the-field-test/
1•konfuzio•17m ago•0 comments

Could ionospheric disturbances influence earthquakes?

https://www.kyoto-u.ac.jp/en/research-news/2026-02-06-0
2•geox•18m ago•1 comments

SpaceX's next astronaut launch for NASA is officially on for Feb. 11 as FAA clea

https://www.space.com/space-exploration/launches-spacecraft/spacexs-next-astronaut-launch-for-nas...
1•bookmtn•20m ago•0 comments

Show HN: One-click AI employee with its own cloud desktop

https://cloudbot-ai.com
2•fainir•22m ago•0 comments

Show HN: Poddley – Search podcasts by who's speaking

https://poddley.com
1•onesandofgrain•23m ago•0 comments

Same Surface, Different Weight

https://www.robpanico.com/articles/display/?entry_short=same-surface-different-weight
1•retrocog•25m ago•0 comments

The Rise of Spec Driven Development

https://www.dbreunig.com/2026/02/06/the-rise-of-spec-driven-development.html
2•Brajeshwar•29m ago•0 comments

The first good Raspberry Pi Laptop

https://www.jeffgeerling.com/blog/2026/the-first-good-raspberry-pi-laptop/
3•Brajeshwar•30m ago•0 comments

Seas to Rise Around the World – But Not in Greenland

https://e360.yale.edu/digest/greenland-sea-levels-fall
2•Brajeshwar•30m ago•0 comments

Will Future Generations Think We're Gross?

https://chillphysicsenjoyer.substack.com/p/will-future-generations-think-were
1•crescit_eundo•33m ago•1 comments

State Department will delete Xitter posts from before Trump returned to office

https://www.npr.org/2026/02/07/nx-s1-5704785/state-department-trump-posts-x
2•righthand•36m ago•1 comments

Show HN: Verifiable server roundtrip demo for a decision interruption system

https://github.com/veeduzyl-hue/decision-assistant-roundtrip-demo
1•veeduzyl•37m ago•0 comments
Open in hackernews

After 60 Years, Diabetes Drug Found to Unexpectedly Impact the Brain

https://www.sciencealert.com/after-60-years-diabetes-drug-found-to-unexpectedly-impact-the-brain
16•ivewonyoung•4mo ago

Comments

andsoitis•4mo ago
Can highly recommend Metformin. I get mine from AgelessRX https://agelessrx.com/metformin/
orionblastar•4mo ago
I take Metformin, which balances out my psych drug weight gain by burning fat. I stick to diet and exercise, which are also factors.
aitchnyu•4mo ago
Will this help psych drug weight gain patients in general? Thinking of a fictional character who wasted years because nobody accepted her getting obese.
orionblastar•4mo ago
It depends on their metabolism. I'm not a doctor, I'm a patient. Consult a Doctor for real information. I'm just giving my opinion. Society tends to fat shame, and many can't help it because the psych drug causes glucose buildup in the blood that leads to weight gain. Metformin lowers glucose in the liver. If you are diabetic like me, you need to read your glucose meter and adjust what you eat and drink.
reify•4mo ago
The wonderful pharma industry.

They prescribe you a drug that does not cure mental illness, that you have to take your entire life, On top of that they make you obese, so you have to take another drug to help you lose weight.

Then the patient has to go through a long and arduous behavioural program to change their life style and eating habits, caused by the drugs in the first place,

The wonderful pharma industry.

High risk of weight gain anti-depressant drugs:

Amitriptyline, citalopram, clomipramine, fluvoxamine, mirtazapine, nortriptyline, paroxetine, phenelzine.

I have seen this over many years in secure psychiatric wards, with those who take antipsychotics.

Drugs do not "cure" mental illnesses. There is no chemical imbalance.

The drugs are either; chemical coshes or highly advertised and ineffective placebo.

ivell•4mo ago
I don't think there is any malicious intend when pharma produces those drugs.

The drugs are also effective in controlling some symptoms and enable people to go on with their life.

We had many centuries without those drugs, I don't think our ancestors had any better quality of life without those meds.

Psychiatric illness is complex and multiple techniques need to be employed to get some control over it.

If we are looking for a silver bullet, I agree there is none.

lm28469•4mo ago
They do pay a shit load of money to advertise them and push doctors to prescribe them so I'd say the malicious intent can definitely be at least argued about
ivell•4mo ago
Not too much different from how cola companies push their products. Though I agree that we should hold pharmaceutical companies to higher standards even in marketing and sales domains.
BizarroLand•4mo ago
There are downsides and side-effects to metformin. I started taking it for life-extension and maybe weight loss support, not for diabetes.

A few months in I started getting pain from my buttocks to my calves whenever I sit for more than 15 minutes. I was concerned that this was some new misery life had thrown at me, but when I looked up the symptoms I found that this is an uncommon side effect of metformin for some people.

This sensation greatly decreased after ceasing metformin, but has not completely subsided 2 months later.

I'm fortunate to have a standing desk at work, but the only way to temporarily mitigate this issue is to go for a long walk or otherwise exercise.

I'm not against it. It helps many people with lots of things, just putting this information out for people who might experience the same issue. Hopefully with this new understanding they will come up with alternatives with lesser issues or that work for people with my response to the medicine.