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What were the first animals? The fierce sponge–jelly battle that just won't end

https://www.nature.com/articles/d41586-026-00238-z
1•beardyw•1m ago•0 comments

Sidestepping Evaluation Awareness and Anticipating Misalignment

https://alignment.openai.com/prod-evals/
1•taubek•2m ago•0 comments

OldMapsOnline

https://www.oldmapsonline.org/en
1•surprisetalk•4m ago•0 comments

What It's Like to Be a Worm

https://www.asimov.press/p/sentience
1•surprisetalk•4m ago•0 comments

Don't go to physics grad school and other cautionary tales

https://scottlocklin.wordpress.com/2025/12/19/dont-go-to-physics-grad-school-and-other-cautionary...
1•surprisetalk•4m ago•0 comments

Lawyer sets new standard for abuse of AI; judge tosses case

https://arstechnica.com/tech-policy/2026/02/randomly-quoting-ray-bradbury-did-not-save-lawyer-fro...
1•pseudolus•5m ago•0 comments

AI anxiety batters software execs, costing them combined $62B: report

https://nypost.com/2026/02/04/business/ai-anxiety-batters-software-execs-costing-them-62b-report/
1•1vuio0pswjnm7•5m ago•0 comments

Bogus Pipeline

https://en.wikipedia.org/wiki/Bogus_pipeline
1•doener•6m ago•0 comments

Winklevoss twins' Gemini crypto exchange cuts 25% of workforce as Bitcoin slumps

https://nypost.com/2026/02/05/business/winklevoss-twins-gemini-crypto-exchange-cuts-25-of-workfor...
1•1vuio0pswjnm7•6m ago•0 comments

How AI Is Reshaping Human Reasoning and the Rise of Cognitive Surrender

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6097646
2•obscurette•6m ago•0 comments

Cycling in France

https://www.sheldonbrown.com/org/france-sheldon.html
1•jackhalford•8m ago•0 comments

Ask HN: What breaks in cross-border healthcare coordination?

1•abhay1633•8m ago•0 comments

Show HN: Simple – a bytecode VM and language stack I built with AI

https://github.com/JJLDonley/Simple
1•tangjiehao•11m ago•0 comments

Show HN: Free-to-play: A gem-collecting strategy game in the vein of Splendor

https://caratria.com/
1•jonrosner•12m ago•1 comments

My Eighth Year as a Bootstrapped Founde

https://mtlynch.io/bootstrapped-founder-year-8/
1•mtlynch•12m ago•0 comments

Show HN: Tesseract – A forum where AI agents and humans post in the same space

https://tesseract-thread.vercel.app/
1•agliolioyyami•13m ago•0 comments

Show HN: Vibe Colors – Instantly visualize color palettes on UI layouts

https://vibecolors.life/
1•tusharnaik•14m ago•0 comments

OpenAI is Broke ... and so is everyone else [video][10M]

https://www.youtube.com/watch?v=Y3N9qlPZBc0
2•Bender•14m ago•0 comments

We interfaced single-threaded C++ with multi-threaded Rust

https://antithesis.com/blog/2026/rust_cpp/
1•lukastyrychtr•15m ago•0 comments

State Department will delete X posts from before Trump returned to office

https://text.npr.org/nx-s1-5704785
6•derriz•15m ago•1 comments

AI Skills Marketplace

https://skly.ai
1•briannezhad•15m ago•1 comments

Show HN: A fast TUI for managing Azure Key Vault secrets written in Rust

https://github.com/jkoessle/akv-tui-rs
1•jkoessle•16m ago•0 comments

eInk UI Components in CSS

https://eink-components.dev/
1•edent•17m ago•0 comments

Discuss – Do AI agents deserve all the hype they are getting?

2•MicroWagie•19m ago•0 comments

ChatGPT is changing how we ask stupid questions

https://www.washingtonpost.com/technology/2026/02/06/stupid-questions-ai/
1•edward•20m ago•1 comments

Zig Package Manager Enhancements

https://ziglang.org/devlog/2026/#2026-02-06
3•jackhalford•22m ago•1 comments

Neutron Scans Reveal Hidden Water in Martian Meteorite

https://www.universetoday.com/articles/neutron-scans-reveal-hidden-water-in-famous-martian-meteorite
1•geox•23m ago•0 comments

Deepfaking Orson Welles's Mangled Masterpiece

https://www.newyorker.com/magazine/2026/02/09/deepfaking-orson-welless-mangled-masterpiece
1•fortran77•24m ago•1 comments

France's homegrown open source online office suite

https://github.com/suitenumerique
3•nar001•26m ago•2 comments

SpaceX Delays Mars Plans to Focus on Moon

https://www.wsj.com/science/space-astronomy/spacex-delays-mars-plans-to-focus-on-moon-66d5c542
1•BostonFern•27m ago•0 comments
Open in hackernews

Rewriting the Grand Plan of Clinical Neuroscience

https://www.psychiatrymargins.com/p/rewriting-the-grand-plan-of-clinical
2•wiry•4mo ago

Comments

reify•4mo ago
For me the USA verison of Psychiatry that has failed everyone.

Since the end of WW2 when the the USA determined that their way was the only way.

From the 1920s, there was tension between the Americans and Europeans over it

The dominant model for thinking about thinking across the Atlantic was Behaviourism, which depended on animals in laboratories, ‘controlled’ experiments, and various other trappings of science.

The Diagnostic and Statistics Manual was borne of the belief about control over the worlds psychiatry from those in the USA.

It has failed. There is no cure for any psychiatric illness or diagnoses. There are of course chemical coshes used in secure psychiatric wards and that is it, the rest are ineffective placebo's that hold many dangers.

Why did the psychiatric community allow the fake "Chemical Imbalance" claims to remain unchallanged for far too long. Simply because they have a hand in big Pharma, and nothing more.

I even taught this complete bullshit to undergratuate students. I drew a brain synapse on a blackboard, with two men in small rowing boats, one boat transfering serotonin back and forth between the synapse, and the other boat blocking the first boat from returning (reuptaking), to simplify how SSRI's work. What a load of bollocks! I feel terrible for having done that.

Then in the 1980's came the SSRI's.

SSRI antidepressants have different names throughout the world but the mechanism of action is the same.

Depression is a natural response to sadness and loss. We humans are well prepared to work through sadness and loss, we dont need drugs to do that.

I have seen far too many people diagnosed with clinical depression and prescribed SSRI's, because they meet 5 criteria in the DSM-5, when they were not clinically depressed.

There was a huge increase in teenage suicides in the 90's. They reduced prescribing to teenagers but assumed adults were OK. So they put warning labels on the packaging for adults, who, in my experience were, and still are, dying of suicides because of the medication they were taking.

I have spent my time in secure psychiatric wards and that is where you find the clinically depressed, who may, or may not, benefit from some sort of medicalised intervention.

SSRI's are generally prescribed on the basis they cure a ‘chemical imbalance’. No chemical imbalances have ever been proven to exist. No tests exist to support this theory, and it is a societal belief based on pharmaceutical marketing.

Instead of correcting biochemical imbalances, the drugs cause biochemical imbalances. Deterioration seen in many patients is not caused by an inherent disease process within the brain, rather a by toxic exposures to psychiatric medication.

I have seen far to many people prescribed anti-depressants for 10 years or more.

I spoke to chap recently who has been, and still is, taking Sertraline for the past 11 years for depression after his mother died, without any follow up review.

The man was a walking Zombie. 11 years of taking an anti-depressant every day for no reason.

This is a human being who was suffering from sadness and loss. There is no need to prescribe any medication for him.

Then there is the elephant in the room: Paradoxical Reaction:

Animal studies demonstrate when initially given Fluoxetine (Prozac), an SSRI Antidepressant , the brain shuts down its own production of serotonin, causing a paradoxical effect or opposite effect on the level of serotonin.

A large 2007 double-blind study of fluoxetine in patients with chronic Depression revealed that nearly one third (30.4%) experienced early worsening of symptoms, defined as a 5-point increase on the Hamilton Depression Rating Scale (HAM-D).

The study emphasized that paradoxical effects are not just isolated anecdotes but designated as “common” and thus represent a measurable risk for a significant portion of patients.

The Suicide Prevention Strategy 2013-2016 included the statistics that 59% of the 5,119 people who died by suicide between 2009 and 2015 in Scotland had at least one mental health drug prescription dispensed within 12 months of death. 82% were prescribed an antidepressant alone or in combination with another drug.

Why are those in the medical professions still prescribing SSRI's???

then there is Post-SSRI Sexual Dysfunction, now recognised in the DSM-5, which they managed to keep quite and deny for 30 years. yet again, I worked with people who suffered with Post-SSRI Sexual Dysfunction 20 years ago.