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SST: Deploy everything your app needs with a single config

https://sst.dev/
1•sigalor•38s ago•1 comments

Larry Ellison, a Media Mogul Like No Other

https://www.nytimes.com/2025/09/23/technology/larry-ellison-oracle-tiktok.html
1•thm•3m ago•0 comments

Patriarchy and Me: Life in a Snow Globe

https://susanpickard.substack.com/p/patriarchy-and-me
1•binning•4m ago•0 comments

US uncovers 100k SIM cards that could have "shut down" NYC cell network

https://arstechnica.com/security/2025/09/us-uncovers-100000-sim-cards-that-could-have-shut-down-n...
1•Mindless2112•5m ago•1 comments

AMD's Inaugural Tech Day Ft. ROCm 7, Modular, and AMD Lab Tour

https://chipsandcheese.com/p/amds-inaugural-tech-day-ft-rocm-7
2•rbanffy•6m ago•0 comments

Ask HN: People are interested, now what?

1•libridev•8m ago•0 comments

The evolution of AI agents in finance

https://didierlopes.beehiiv.com/p/the-evolution-of-ai-agents-in-finance
1•sexy_year•10m ago•0 comments

To Save Bears from Florida Hunts, Activists Are Buying Up Bear Tags

https://cowboystatedaily.com/2025/09/21/to-save-bears-from-florida-hunts-activists-are-buying-up-...
4•Bender•10m ago•0 comments

AI's Dark Side: Hype Bubbles, Job Loss, and Control?

https://lightcapai.medium.com/technology-at-a-crossroads-abundance-hype-and-the-human-factor-64df...
1•WASDAai•10m ago•1 comments

A deep dive into memory allocation in Golang

https://nghiant3223.github.io/2025/06/03/memory_allocation_in_go.html
1•fanf2•10m ago•0 comments

Mainframed/ANSi2EBCDiC: convert ANSI art to EBCDIC/TN3270 art

https://github.com/mainframed/ANSi2EBCDiC
1•rbanffy•10m ago•0 comments

Certified Shovelware

https://justin.searls.co/shovelware/
1•searls•12m ago•1 comments

Accountant/CPA Search in Cali/Texas

1•chilitos97•12m ago•0 comments

Kabuki Quantum Fighter

http://www.hardcoregaming101.net/kabuki-quantum-fighter/
1•indigodaddy•13m ago•0 comments

Oracle gets to store US users' TikTok data

https://www.theregister.com/2025/09/23/oracle_gets_to_store_us/
2•Bender•14m ago•0 comments

GitHub moves to tighten NPM security amid phishing, malware plague

https://www.theregister.com/2025/09/23/github_npm_registry_security/
3•Bender•14m ago•1 comments

To Be Heard

https://seths.blog/2025/09/to-be-heard/
1•mooreds•15m ago•0 comments

Anthropic bans companies majority-controlled by China, Russia, Iran, North Korea

https://the-decoder.com/anthropic-bans-companies-majority-controlled-by-china-russia-iran-and-nor...
7•amai•16m ago•1 comments

Show HN: Kuvasz Uptime 3.1.0 – now with Status Pages

https://github.com/kuvasz-uptime/kuvasz/releases/tag/3.1.0
5•selfhst12•18m ago•0 comments

Xet powers 5M models and datasets on Hugging Face

https://twitter.com/ClementDelangue/status/1970512794303807724
1•clmnt•18m ago•1 comments

What if Humanity forgot how to make CPUs? [video]

https://www.youtube.com/watch?v=L2OJFqs8bUk
1•surprisetalk•20m ago•0 comments

Fractran Programming Language

https://en.wikipedia.org/wiki/FRACTRAN
2•KolmogorovComp•21m ago•0 comments

The influencer in this Vodafone ad isn't real

https://www.theverge.com/news/773567/vodafone-generative-ai-ad-presenter-tiktok
1•emreb•22m ago•0 comments

Show HN: Lost and Found Management Simplified

https://www.reclaimdesk.com/
4•truetaurus•23m ago•0 comments

I only know how to download and install apps. Make an EXE file and give it to me

https://old.reddit.com/r/github/comments/1at9br4/i_am_new_to_github_and_i_have_lots_to_say/
2•redbell•23m ago•0 comments

Brazil Lobbies EU, China to Join COP30 Carbon Market Coalition

https://www.bloomberg.com/news/articles/2025-09-23/brazil-lobbies-eu-china-to-join-cop30-carbon-m...
3•wslh•24m ago•1 comments

Show HN: BetterHN – Sleek and Clean HN Reader

https://betterhn.com/top
1•pacific01•24m ago•0 comments

Targetting specific characters with CSS rules

https://shkspr.mobi/blog/2025/09/targetting-specific-characters-with-css-rules/
2•mtlynch•25m ago•0 comments

Nominative Determinism

https://en.wikipedia.org/wiki/Nominative_determinism
3•ibobev•25m ago•1 comments

Openphone Rebrands to Quo, adds caller AI to all tiers, New $105M Funding

https://www.quo.com/new-chapter
2•ravetcofx•25m ago•1 comments
Open in hackernews

FDA takes action to make a treatment available for autism symptoms

https://www.fda.gov/news-events/press-announcements/fda-takes-action-make-treatment-available-autism-symptoms
47•amai•1h ago

Comments

tencentshill•1h ago
The cure is a simple pill, provided by a company with a long history of corruption, prosecuted for "promotion of drugs for unapproved uses, failure to report safety data and kickbacks to physicians in the United States".

A company that operates like that sees opportunity in this US administration.

https://en.wikipedia.org/wiki/GSK_plc

vkou•1h ago
If the adults ever return to the room, what exactly should be done by everyone responsible, to make nobody else even dream of doing this?
throwup238•1h ago
A never ending vigilance against corruption. That’s the only real solution — any other system or set of rules can be undone.
ryandrake•1h ago
If the electorate wants a circus, they'll elect clowns. There's really not much non-clowns can do about it if elections are to be maintained and fair.
mpalmer•1h ago
Until elections become something else entirely, and then the non-clowns can do even less.
atmavatar•1h ago
Practically speaking, no amount of punishment for fascists will ensure that another set of fascists won't rise up again in the future. There's far too much to gain by taking over political power for any deterrent to work effectively.

The best solution is to improve education to help people see through the bullshit that got us here. In particular, teach people that campaigning through memes, emotional appeals, and demonization of minority groups are big neon signs that the campaigning group does not have your best interests in mind.

cbeach•1h ago
Which "fascists" are we talking about, here?

Be careful around powerful words with meaning (see https://en.wikipedia.org/wiki/Fascism ). If we casually use these words to refer to people we simply disagree with - one day, when actual fascists start rising, we'll have taken all the meaning out of the language we rely on to identify them.

bongodongobob•1h ago
Trump and his cronies. Who the fuck do you think.
cbeach•1h ago
Trump doesn't pass the fascism test, I'm afraid:

* Dictatorial leader - Trump ceded power at the end of his last term, and the opposition had a term. That doesn't happen in a dictatorship.

* Centralised autocracy - Trump has maintained the US political system with its checks and balances.

* Militarism - As with his previous term, Trump is more interested in creating peace treaties (e.g. the Abraham Accords) than participating in wars.

* Forcible suppression of opposition - Democrats have not been suppressed

* Belief in a natural social hierarchy - Trump believes in meritocracy, not any other order.

* Subordination of individual interests for the perceived interest of the nation or race, and strong regimentation of society and the economy - Trump is the archetypal capitalist - he believes all people should strive to produce with free enterprise, and have an ownership stake in the means of production via the free market. Fascist regimes, on the other hand, have a top-down regimentation of the economy akin to socialism (which is no surprise, as Musollini and Hitler were both socialists before they developed fascism).

esseph•58m ago
Holy shit you really believe this don't you
imoverclocked•42m ago
Be careful with this type of argument. It can be easily employed by “both sides” since the information each side is working from supports their own view and simply polarizes each side further.
imoverclocked•45m ago
> Trump ceded power at the end of his last term

Jan 6th is a well known counterexample

> Trump has maintained the US political system with its checks and balances

Trump has used emergency powers to do almost everything since the start of this term. This includes tariffs.

> As with his previous term, Trump is more interested in creating peace treaties

He has increased funding to DHS and renamed the DoD to DoW (Defense vs War)

> Democrats have not been suppressed

Melissa and Mark Hortman were murdered by a right wing nut job. Charlie Kirk (a YouTuber) was given the honor of flags at half mast for a week.

The rest of your arguments also don’t jive with what I know about him.

cbeach•24m ago
> Jan 6th is a well known counterexample

Trump took to social media to denounce political violence on that day, but a small bunch of unorganised Trump supporters entered the Capitol during a protest. One person was tragically killed (a Trump supporter). The political transition happened.

> Trump has used emergency powers to do almost everything since the start of this term. This includes tariffs.

He's made a number of executive orders to achieve the actions he promised in the manifesto that got him democratically elected. Few politicians have been as true to their word as Trump, in terms of delivering the change that the people voted for.

Trump has not changed the political system. He has merely used its existing executive powers.

> He has increased funding to DHS and renamed the DoD to DoW (Defense vs War)

So what? What wars has he started? How does his record compare to the Democrat presidents that preceeded him?

> Melissa and Mark Hortman were murdered by a right wing nut job.

You found one incident of a nut job. That does not mean the Democrat opposition has been suppressed by Trump. And what do you say about the multiple assasination attempts on Trump?

It's clear where the political violence is coming from.

MSFT_Edging•1h ago
> when actual fascists start rising, we'll have taken all the meaning out of the language we rely on to identify them.

Isn't this a delightful Catch-22.

If you forewarn about a developing Fascist movement, you're simply taking away the meaning from the word until it's too late and the Fascists take power.

You cannot call anything Fascist, for there may be something more Fascist that may need the power of the word.

But ah! We couldn't call out their fledgling movement full of dog whistles and double speak so no one was aware enough to stop them as a fledgling movement!

esseph•58m ago
Nonsense.

We killed a bunch of Italian fascists and Nazis but never learned to deal with the ideology.

Modern Americans could look at many of Mussolini's policies today and wouldn't bat an eye.

imoverclocked•57m ago
We have lived in a period without significant fascism in power. Fascism doesn’t start with concentration camps and gas chambers, it builds up to them. It’s easy to dismiss because we were taught about just how bad it got but surely it’s not that bad _here_. The problem is, it’s only getting worse and ignoring it is how it got so bad in the past.

Fascists are continuing to rise right now. Googling “Hallmarks of fascism” gives us an AI overview:

Key hallmarks of fascism include fervent nationalism, authoritarian leadership, the suppression of opposition, and the use of violence to achieve national rejuvenation. …

We blatantly have all of those things from the current administration.

yibg•44m ago
Also fascism doesn't require concentration camps and gas chambers, it just has little to prevent them. There have been fascists that also didn't involve gas champers etc. So to say only when we get concentration camps is there fascism is also just wrong
cbeach•39m ago
> We blatantly have all of those things from the current administration. > fervent nationalism

I grant you, Trump supporters are heavily nationalist. Supporters of Winston Churchill in the UK were also fervently nationalist, when the UK was protecting Europe against actual fascists.

You cannot extrapolate fascism from nationalism.

> authoritarian leadership

An authoritarian regime grows the size of the state to cement its power. Trump is more of a libertarian, demonstrably reducing the scale and power of the state apparatus (DOGE)

> the suppression of opposition

Biden, and Biden-aligned judges weaponised the law against Trump, with spurious cases and fines. They tried to pin anything they could on Trump, in an attempt to prevent him becoming president.

Trump has not done anything similar against Harris, Clinton or Biden.

> the use of violence to achieve national rejuvenation

Nope.

Compare what happened in Democrat cities in the wake of George Floyd's death vs what's happening in Republican areas after Charlie Kirk's assasination. There was riots and looting, and Antifa intimidation of political opponents for Floyd. There are peaceful, respectful vigils for Kirk.

---

> Fascism doesn’t start with concentration camps and gas chambers, it builds up to them.

Trying to extrapolate a "fascist" future version of the current Trump regime is an example of the "Slippery Slope" logical fallacy.

imoverclocked•12m ago
> An authoritarian regime grows the size of the state to cement its power

| The OBBBA adds $170 billion for immigration enforcement agencies like Immigration and Customs Enforcement (ICE) and Customs and Border Protection (CBP) [1]

> Biden, and Biden-aligned judges weaponised the law against Trump, with spurious cases and fines

Trump has weaponized the DOJ [2]

Trump was convicted of felonies and other crimes; They were not spurious. He claims that he was targeted and a victim but he is also a well-known scam artist. "Accusation in a mirror" [3] fits much of his rhetoric.

> Trump has not done anything similar against Harris, Clinton or Biden

Does "Lock her up!" ring any bells?

Why doesn't Trump's "Hunter Biden" hunt register here?

> Compare what happened in Democrat cities in the wake of George Floyd's death vs what's happening in Republican areas after Charlie Kirk's assasination

It's telling that you say "death" vs "assassination" in the two cases; George Floyd was murdered. The "riots and looting" you speak of are contested as being a separate act unrelated to the original message through peaceful protest. Maybe choose a better example... and maybe one that isn't as recently charged ... and one that isn't being widely compared to Horst Wessel.

> Trying to extrapolate a "fascist" future version of the current Trump regime ...

I'm not; It's already fascist right here, right now.

[1] https://www.dhs.gov/news/2025/07/04/secretary-noem-commends-...

[2] https://www.google.com/search?q=trump+weaponized+the+doj

[3] https://en.wikipedia.org/wiki/Accusation_in_a_mirror

BizarroLand•38m ago
cbeach is espousing glowie talking points.

Safe to say they are not arguing in good faith or are a person expressing their own ideas, and can therefore be ignored.

xnx•1h ago
Educating people to resist fascism is at odds with educating them to be obedient/subservient worker bees.
RobRivera•1h ago
The first line of defense is the power of NO as a patient.

Easier said than done and requires staying on top of literature and sourcing multiple opinions.

Maybe trips abroad to get that alternative opinion for peace of mind?

All spoken from an understanding that the average person cannot afford the time or expense associated with this idea.

MSFT_Edging•1h ago
1: Police unions: Police in this country hold a monopoly on violence granted by the state. Police unions in turn have created a political bubble around the holders of this monopoly. By politicizing what should essentially be a public servant, we have made any accountability for these public servants very difficult to perform.

2: Breech of public trust can never be punished with a slap on the wrist. There cannot be "get out of jail free" sentencing for people of note. That deconstructs any trust anyone can have in the system, if there exists a class who cannot have the law applied to them.

3: A bill of Human rights, designed to encompass attempts to remove rights from certain people. A focus on positive rights, ie "the right to live", rather than negative rights "the right to cause damage to others via an existing right(property rights)".

4: Overturning of citizens united or the ability to punish corporations in an equivalent measure to how an individual can be punished. The fines must always be greater than what can be saved by exploitation via crime.

That's more or less a start. I'm no political scientist but to me these are big points of gridlock.

billy99k•1h ago
You mean the 'adults in the room' that pushed an unproven Covid vaccine from those same corrupt companies?

The Democrats wouldn't take the Covid vaccine when it first came out and called it the 'Trump vaccine' on CNN...until they came into power. Then they made a 180.

During the Covid era, you most likely lost your job and were censored from all major platforms if you had an opinion about the Covid vaccine that didn't match exactly what the government told us.

What would you think about getting this same treatment for this?

esseph•1h ago
The biggest block of voters in this country are independents, not Democrats or Republicans.
danorama•1h ago
“The Democrats wouldn't take the Covid vaccine when it first came out and called it the 'Trump vaccine' on CNN...until they came into power. Then they made a 180.”

[citation needed]

vkou•45m ago
> unproven Covid vaccine

Please inform yourself. Both approved vaccines were rigorously tested. Unlike other vaccines, multiple phases of those tests were done concurrently, which is why it shipped in 6 months, instead of 3 * 6 months.

> The Democrats wouldn't take the Covid vaccine when it first came out

This begins to cast doubt that you will inform yourself, but from day 1, vaccine uptake was much higher, and continues to be much higher in blue states.

The only person who flip-flopped on vaccines was Trump, because he realized that his base is far too stupid to appreciate what Operation Warp Speed did for them.

reissbaker•1h ago
GSK is one of the largest pharma companies in the world, created the malaria vaccine, the first HIV antiretroviral, amoxicillin, valacyclovir, and like a zillion other important drugs.

It's also not even an American company, despite your insinuation: it's British. This isn't some fly-by-night operation created by Trump or whatever.

How well will this pill work? I don't know. There is reasonably good research [1], (carried out during the Biden administration btw!) that a large percentage of autism is linked to folate deficiency due to autoantibodies that wreck your folate pathways, and that d,l-leucoverin bypasses those and restores folate to developing brains.

Complaining that it's "a simple pill" to me feels pretty anti-intellectual. So were antibiotics, so were antivirals, so were many other treatments for horrible diseases that just... are solved now. The fact that it's pill-shaped tells you nothing about the research it took to develop.

1: https://pubmed.ncbi.nlm.nih.gov/34834493/

rdtsc•1h ago
Wondering which drug companies are trustworthy. Let's say if this was Eli Lilly or Pfizer, would that make the announcement blurb better? As in, we see it and say "oh wow, that's sounds great". I imagine if we insert any name in there it would still read just about the same?
formerly_proven•1h ago
I bet it’s a really good sign that the history section of Novo Nordisk on Wikipedia skips directly from the 1920s to the 1980s.
rdtsc•29m ago
Yikes, indeed
morkalork•1h ago
Apparently Dr Oz stands to profit from one of those approvals..
vasusen•1h ago
Like many things where what constitutes base data changes and hence graphs change pretty radically, this can be cleanly explained by diagnostic drift. Here's a detailed breakdown: https://www.cremieux.xyz/p/how-to-end-the-autism-epidemic
Glyptodon•1h ago
This isn't a serious article.

While it's true that parents and schools have a weird relationship with ASD, with some parents doing anything to refuse the label no matter how apt, at other times with officials and parents going out of their way to do things like label kids with symptoms of severe trauma as having ASD, along with a long tail of higher SES parents who see claiming various special ed needs (not just ASD ones) as a way to get more resources for their children, particularly in states where they can get additional vouchers or payments with a label, these things don't really change a ground truth: severe autism is not easy to hide or easy to fake, and cases are increasing.

IMO diagnostic drift is maybe a fine thing hem and haw about when it comes to mild cases.

But it's basically a form a bike shedding because the severe cases are so incontrovertible and so much more common than they used to be. You can't claim that kids with severe cases are okay and just out to get money because they're so obviously and clearly not well. And schools have gone from maybe having none to a couple per grade to needing whole classrooms or even schools to safely handle high severity autism over the last 50 years.

You could maybe instead claim that "when achieving any semblance of normalcy is impossible, society shouldn't spend so much effort," but that is usually not a well-received message because it sounds like the forced institutionalization or incarceration of the mentally ill or locking them in bedrooms to be forgotten.

Similarly, there are some situations where the repercussions of severe early childhood trauma get diagnosed as autism, but these are also situations where you'd still have a massive service need, so there's no cost reduction to be had, just a proportionally small chunk of misdiagnosis.

amanaplanacanal•1h ago
Are severe cases more common? Do you have some papers exploring this?
Glyptodon•46m ago
I will ask someone more knowledgeable than me about this when I have a chance, but I think it became common to look at the severe cohort under the label of "profound autism," a few years ago, but I think has a tendency to be listed as a % of overall ASD cases rather than a separate rate.
Glyptodon•1h ago
I'm surprised they didn't just "partner" with General Mills or some such to turn this into an advertisement for folate fortification in sugary breakfast cereals.

For those replying: I did not mean this would seriously work, but that it would be par for this administration to basically bring cereal ads from Saturday morning cartoons into the CDC.

incomingpain•1h ago
The typical folate in food or even the pregnant women folic acid supplement is good at preventing these birth defects; but for someone with NDD it would actually not help and depending on dose block up the pathways for it to heal.
trehalose•1h ago
Leucovorin works (at least for some cases of CFD) because it bypasses a folate transport protein that can be nonfunctional and fail to transport ordinary folic acid into the brain. I guess that doesn't necessarily mean they couldn't do what you're suggesting though.
reenorap•48m ago
The dose in the pill is very high, it's not something you can just let everyone take.
p_ing•1h ago
Zero references to medical studies.
cpncrunch•1h ago
https://pmc.ncbi.nlm.nih.gov/articles/PMC7477301/

https://pubmed.ncbi.nlm.nih.gov/34834493/

p_ing•1h ago
What does that have to do with the link page which contains zero references to medical studies?
lupusreal•1h ago
This pill is an obvious scam. Legos are the treatment. Give autistic kids more legos.
bobmcnamara•55m ago
No Lego. Only TRAAAAIIIINS
dsr_•1h ago
This is absolute corruption of the FDA's mission to accurately label and appropriately market drugs.

The evidence is from a study with N=40. Not 40,000. 40.

metalcrow•1h ago
Can you link to the study? The release implies there are multiple but doesn't link to any
bunderbunder•40m ago
Here's a PubMed search. https://pubmed.ncbi.nlm.nih.gov/?term=leucovorin+cerebral+fo...

It's worth noting that, in the absence of pre-registration, one should should assume that the body of literature (and any systematic review or meta-analysis that relies on it) could be significantly influenced by the file drawer effect.

Anyway, I looked at a recent systematic review from those search results (https://pmc.ncbi.nlm.nih.gov/articles/PMC8622150/), and it found exactly one double-blind RCT (https://pmc.ncbi.nlm.nih.gov/articles/PMC5794882/) that seemed to support what the FDA is saying here. It had a fairly short duration (12 weeks) and a small cohort (48). I'm not medical expert but I do read medical literature as an amateur, and I'm pretty sure this is nowhere close to the standard of evidence for establishing safety and efficacy that the FDA used to demand. It feels like we may be reverting all the way back to the evidentiary standards that allowed crap like thalidomide onto the market.

OkayPhysicist•53m ago
Sample size doesn't tell you everything about a study. You don't need to throw 40,000 people out of an airplane to determine it's safer with a parachute.
yibg•49m ago
This gets brought up often and while true isn't very useful. We know jumping out of plane is dangerous because we have a good understanding of the physics and we have many many comparable examples (jumping out of buildings etc). We understand the mechanism of action of parachutes, so we also know for example a tiny little parachute made of paper towel won't work, and we don't need to test it to know that.

Do we understand the cause of autism or how this supposed cure works?

OkayPhysicist•46m ago
The key is effect size. We didn't know the exact method of action when we started injecting comatose diabetic children with insulin, but when the coma patient sits up and starts chatting with you, you can establish that a drug is effective with very small sample sizes.
yibg•41m ago
Sure, but even there you need some reasonable sample size. i.e. a sample of 1 won't be sufficient and more importantly it needs to be reproducible. Inject 1 patient and they wake up, but if you inject 10 others and nothing happens and it may not be effective (not that it's definitely not effective). This would require a then a larger sample size.
bunderbunder•36m ago
It does tell you something. But that kind of sample size is arguably underpowered for anything but a preliminary study. It's the statistical equivalent of Hubble before it had its corrective optics installed: still fine for seeing big unsubtle things like whether parachutes are warranted when jumping from airplanes, but unable to resolve all the details you want to know before concluding that a medication is safe and effective.
thaw13579•6m ago
I reviewed the linked studies of folinic acid treatment in ASD, and they uniformly say that larger studies are needed before considering this as a widely available treatment. The main issues that need to be worked out are:

* who this applies to (some studies suggest genotype and autism subtype matter for getting positive outcomes)

* what the side effects are (12 week studies of <100 people are not enough to safely deploy this as a long-term treatment at scale)

* how this compares to behavioral treatment (ABA and sensory interventions have reliable positive outcomes as well)

I think there's a useful signal there, but we need to be cautious rolling things out at a national scale without bigger studies.

leakycap•1h ago
> "The U.S. Food and Drug Administration today initiated the approval of leucovorin calcium tablets for patients with cerebral folate deficiency (CFD) ... Individuals with cerebral folate deficiency have been observed to have developmental delays with autistic features (e.g., challenges with social communication, sensory processing, and repetitive behaviors), seizures, and problems with movement and coordination."

The wording, my emphasis added, certainly suggests this is a new med for CFD even though the title mentions Autism symptoms, not CFD

Search for the word autism in the release and tell me if you think this treats what they suggest in the title. It would be every other word if they believed it.

newobj•1h ago
I know they're not serious because they didn't recommend methylcobalamin.

Kinda funny how in all this chatter no one is talking about MTHFR etc.

malfist•1h ago
Perhaps because B12 supplementation isn't a cure for autism?
josefritzishere•1h ago
This is the Amway administration. I am running out of words.
silverquiet•1h ago
That was the last Trump administration, where the Secretary of Ed was married to the CEO of Amway. The current one is the former CEO of World Wrestling Entertainment, so I'd say it's more the Pro Wrestling administration.
kg•1h ago
I worry that once it turns out this doesn't actually work, there's going to be a revolving door of the 'next new Autism fix' and gradually kids with autism are going to be loaded up with more and more drugs of unproven effectiveness based on low-quality studies.
calebm•1h ago
So good to see them actually addressing the Autism epidemic. Some people are still parroting the "Autism has not increased - it's just a difference in diagnostic criteria" BS.
pklausler•1h ago
The next pandemic is going to be an epic disaster.
Mizza•1h ago
WashPo article on this was interesting: https://www.washingtonpost.com/health/2025/09/22/leucovorin-...

Seems like it works only for a very specific type of childhood autism, but if my child had this I would be kicking down doors to get it. The article has some good insight into how honest researchers feel about their work being trumpeted by the scientifically illiterate carnival barkers in charge of things.

ornornor•1h ago
Can you imagine if it had been a vaccine rather than a pill?
xkcd-sucks•1h ago
Based on the manufacturer's history, nothing good: https://en.wikipedia.org/wiki/GSK_plc#2010_Pandemrix_connect...
jmclnx•1h ago
Does anyone with knowledge still pays attention to .gov sites ? Seems they are all filling up at different rates with pseudo science, or in other cases, removing science facts.
jkaplowitz•1h ago
.gov is available to nonfederal US governmental entities as well. Those .gov sites run by states and cities which still believe in science are still worth paying attention to. Also even federal .gov sites remain reliable for certain topics like giving current statutory or regulatory text.
nineplay•1h ago
Looking for The Cause of autism and The Cure for autism is exactly as absurd as looking for The Cause of cancer and The Cure for cancer. I think most people understand that there are many causes of cancer and many treatments that cover a range of different use cases.

The whole concept of a cause and cure is really damaging to the autistic community and just flying in the face of any sort of intelligent diagnosis and treatment.

estimator7292•1h ago
I'm about 98% certain this is simply a ploy to put autistic people on a list for future abuses.

In today's political climate, nobody should be revealing their autism status to anyone remotely connected to any level of government. Nor should one trust any sort of medical advice or reporting from same. Our government is explicitly targeting minorities of all sorts for abuse and persecution.

Now is, unfortunately, the time to hide and weather the storm. That or flee to another country with a functioning society.

Please protect your autistic children and friends. Times are real, real bad for them right now.

incomingpain•6m ago
>I'm about 98% certain this is simply a ploy to put autistic people on a list for future abuses.

I'm a foreigner, not even in the USA. Your politics are melting down but I feel like the FDA isn't tracking or seeking to harm you.

>In today's political climate, nobody should be revealing their autism status to anyone remotely connected to any level of government. Nor should one trust any sort of medical advice or reporting from same. Our government is explicitly targeting minorities of all sorts for abuse and persecution.

Pretty strong argument against socialized medicine. Here in Canada the government actively tracks each of these. For example to get the covid shot, they wanted to know about my autism, non-binary/trans etc. They werent just asking everyone this, I didnt bring it up because why would it matter? I was in their system. I also happen to know this data is being transferred out of country to CDSI; ASN 23498.

>Now is, unfortunately, the time to hide and weather the storm. That or flee to another country with a functioning society.

I dont think you need to flee the usa. Canada has drastically reduced migration, you dont want to come here. Europe maybe?

tonmoy•59m ago
> The FDA has conducted a systematic analysis of literature published between 2009-2024, including published case reports with patient-level information, as well as mechanistic data, and has determined that the information supports a finding that leucovorin calcium can help individuals suffering from CFD.

I would have liked to see some citations. I’m mostly curious about the sample sizes

sys32768•54m ago
For the non-partisans who actually care more about autism in children than they do throwing ideological jabs, there are numerous interesting anecdotal reports from parents of children who have been trying leucovorin in the past year or so:

https://www.reddit.com/r/Autism_Parenting/search/?q=leucovor...

My hope is that this does lead to breakthroughs in understanding the mechanism for some types of autism, and perhaps even a "miracle" drug akin to how stimulants can radically transform the brains of many with ADHD.

yibg•52m ago
You can have anecdotal about anything in any direction. Not a great way to come to a scientific conclusion.
reissbaker•47m ago
Can you also have clinical trials performed under the Biden administration that "significantly improve communication with medium-to-large effect sizes and have a positive effect on core ASD symptoms and associated behaviors" about anything in any direction?

https://pubmed.ncbi.nlm.nih.gov/34834493/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7477301/

yibg•40m ago
I'm not sure how that's related. Some research is flawed and statistics provide misleading or incorrect data so we just... don't care about data?
reissbaker•19m ago
I am pointing out that your claim that this is just anecdotal is incorrect. There is published research showing medium-to-large effect sizes for exactly this treatment. Why do you think people were trying it on Reddit in the first place?