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Bay Area biotech Arsenal Bio lays off half its workers a yr after raising $325M

https://www.sfgate.com/tech/article/arsenal-biotech-lays-off-half-21061658.php
4•randycupertino•1h ago

Comments

duxup•1h ago
Bio tech and start up style ... failing fast seems like an incompatible thing.

Bio tech seems like it often requires tons of iterations on an idea that take a very long time. Meanwhile start up land is often "nope that first shot didn't get any uptake, guess we're done".

randycupertino•1h ago
Also BMS recently pulled out of their collaboration with Arsenal so in this case they were probably counting on more easy $$ from that partnership after burning through their previous $325m raise.
randycupertino•1h ago
Even if the science is strong, so many flash in the pan cell therapy startups just can't execute on clinical operations. They get through IPO on investor FOMO and promises of exciting times ahead but then the stock tanks tanks when the trials take forever, cost more than anticipated and no other drugs to fall back on.

Rough market for the 127 people laid off.

Microsoft microfluidic channels cool GPU 65%, outperform cold plates by up to 3x

https://www.tomshardware.com/pc-components/liquid-cooling/microsoft-develops-breakthrough-chip-co...
1•westurner•1m ago•1 comments

NFS at 40

https://nfs40.online/
1•fjarlq•2m ago•0 comments

Can Liberalism Be Saved?

https://www.newyorker.com/news/q-and-a/can-liberalism-be-saved
1•paulpauper•5m ago•0 comments

Do Soil Methanotrophs Remove About 5% of Atmospheric Methane?

https://www.mdpi.com/2073-445X/14/9/1864
1•PaulHoule•5m ago•0 comments

GitHub MCP Registry

https://github.com/mcp/
1•saikatsg•5m ago•0 comments

Build a Bear Success

https://www.washingtonpost.com/business/2025/09/22/build-a-bear-success-tariffs/
1•paulpauper•6m ago•0 comments

We should not auction off all H1B visas

https://marginalrevolution.com/marginalrevolution/2025/09/why-we-should-not-auction-off-all-h1-b-...
2•paulpauper•7m ago•0 comments

3D Printing of Magnesium-Containing Biomedical Materials for Bone Repair

https://www.frontiersin.org/journals/materials/articles/10.3389/fmats.2025.1682972/abstract
1•westurner•7m ago•0 comments

Suggestions for Increasing Trust in Automated Driving

https://www.aptiv.com/en/insights/article/increasing-trust-in-automated-driving
1•ohjeez•9m ago•0 comments

Why is Windows still tinkering with critical sections? – The Old New Thing

https://devblogs.microsoft.com/oldnewthing/20250924-00/?p=111624
2•OptionOfT•9m ago•0 comments

Supermicro server motherboards can be infected with unremovable malware

https://arstechnica.com/security/2025/09/supermicro-server-motherboards-can-be-infected-with-unre...
2•zdw•9m ago•0 comments

iOS 26.1 hints at iPhone adding support for third-party smartwatches

https://9to5mac.com/2025/09/24/ios-26-1-hints-at-iphone-adding-support-for-third-party-smartwatches/
1•alwillis•11m ago•0 comments

The Village and the Sewer – Behind the "Blueskyism" Debate

https://www.programmablemutter.com/p/the-village-and-the-sewer
2•verdverm•11m ago•0 comments

Tinder, Hinge, and Their Corporate Owner Keep Rape Under Wraps

https://themarkup.org/investigations/2025/02/13/dating-app-tinder-hinge-cover-up
7•rendaw•12m ago•0 comments

Day trading is about to get easier for smaller retail investors

https://www.cnbc.com/2025/09/24/day-trading-is-about-to-get-easier-for-smaller-retail-investors.html
1•OutOfHere•13m ago•0 comments

Who is that actor on the screen? Emacs/LLM/Fun Redux – Random Thoughts

https://lars.ingebrigtsen.no/2025/09/24/who-is-that-actor-on-the-screen-emacs-llm-fun-redux/
1•samtrack2019•13m ago•0 comments

Airbyte 2.0

https://airbyte.com/blog/airbyte-2-0
1•jamesriso•13m ago•0 comments

.faf – The JPEG for AI is YAML and noodles

https://www.faf.one/press-release
2•wolfejam•14m ago•0 comments

Show HN: tetradoom - from dos to desktop using only host system libraries

https://www.youtube.com/watch?v=QB8MpXEuA6k
1•Oxodao•15m ago•0 comments

YouTube will begin reinstating banned creators

https://apnews.com/article/youtube-reinstatement-covid-election-misinformation-5809a1da0afece53d6...
2•01-_-•17m ago•1 comments

LLMs can now generate 3D models (example)

https://i.imgur.com/WUiUzH9.png
1•addy999•18m ago•1 comments

Kimmel says attempt to "cancel" him "backfired"

https://www.complex.com/pop-culture/a/tracewilliamcowen/kimmel-says-effort-to-cancel-him-backfire...
3•01-_-•19m ago•0 comments

List of .gov.uk Domain Names

https://www.gov.uk/government/publications/list-of-gov-uk-domain-names
1•robin_reala•20m ago•0 comments

Show HN: Postgres-Backed Durable Workflows in Go

https://github.com/dbos-inc/dbos-transact-golang
3•KraftyOne•21m ago•1 comments

My Thoughts on Euruko

https://noteflakes.com/articles/2025-09-23-euruko
1•janpio•22m ago•0 comments

Solarpunk and the Way Out

https://old.anemon.es/notes/simondon.html
2•xk3•22m ago•0 comments

Show HN: CloudQA – TruRT: Regression Testing That Doesn't Break Every Sprint

1•ArunCQA•23m ago•0 comments

Introducing PrediBench – Leaderboard of LLMs Betting on Polymarket

https://predibench.com/
1•aubanel•23m ago•0 comments

How Innovative Companies Leverage Analyst Research Firms

https://guptadeepak.com/the-complete-guide-to-analyst-research-firms-how-innovative-companies-nav...
1•guptadeepak•24m ago•0 comments

Is Gen Z Unemployable?

https://www.wsj.com/opinion/is-gen-z-unemployable-288d2ec9
4•sandwichsphinx•24m ago•1 comments