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Startups could be affected by a prolonged government shutdown

https://techcrunch.com/2025/10/02/how-startups-could-be-affected-by-a-prolonged-government-shutdown/
1•rbanffy•43s ago•0 comments

Biohybrids for Sustainable Chemical Synthesis

https://www.maxapress.com/article/doi/10.48130/een-0025-0002
1•PaulHoule•1m ago•0 comments

Sunrun's 37,000 home batteries are bailing out Puerto Rico's grid

https://electrek.co/2025/07/21/sunrun-37000-home-batteries-are-bailing-out-puerto-ricos-grid/
1•JumpCrisscross•2m ago•0 comments

SaaS turbo-charged software spending tough for CIOs to control, says research

https://www.theregister.com/2025/10/02/saas_turbocharged_software_spending_tough/
1•rntn•2m ago•0 comments

Y'all are over-complicating these AI-risk arguments

https://dynomight.net/ai-risk/
1•bobbiechen•3m ago•0 comments

Scaling quantum computing even faster with Atlantic Quantum

https://blog.google/technology/research/scaling-quantum-computing-even-faster-with-atlantic-quantum/
2•mikece•3m ago•0 comments

The Mississippi Miracle Doesn't Scale; Building Implementation Capacity Does

https://www.governance.fyi/p/the-mississippi-miracle-doesnt-scale
1•toomuchtodo•4m ago•0 comments

Russ Vought's plan to deconstruct the government was years in the making

https://www.cnn.com/2025/10/02/politics/russ-vought-shutdown-architect
1•rbanffy•4m ago•0 comments

OpenServ – Lovable for AI Workflows

https://twitter.com/openservai/status/1973787073418350975
1•arbayi•4m ago•0 comments

How to align teams and get things done

https://www.hyperact.co.uk/blog/workshops-that-work
1•imjacobclark•7m ago•0 comments

Show HN: IndieDevs 2.0 – Developer community and Portfolio Builder

https://www.indiedevs.me/
1•emanueledpt•8m ago•1 comments

Don't Forget: Remote MCP Servers Are Just Curl Calls

https://www.joshbeckman.org/blog/practicing/dont-forget-remote-mcp-servers-are-just-curl-calls
2•bckmn•8m ago•0 comments

In a Sea of Tech Talent, Companies Can't Find the Workers They Want

https://tech.slashdot.org/story/25/10/02/1044234/in-a-sea-of-tech-talent-companies-cant-find-the-...
1•FreeQueso•9m ago•1 comments

UK makes new attempt to access Apple cloud data

https://www.ft.com/content/d101fd62-14f9-4f51-beff-ea41e8794265
2•frizlab•11m ago•1 comments

A new game "Take it Personal"

1•simpaticoder•11m ago•0 comments

Papertrail: You Used to Be Perfectly Ok

https://blog.greg.technology/2025/10/01/papertrail.html
2•gregsadetsky•11m ago•0 comments

Sophistical Refutations

https://en.wikipedia.org/wiki/Sophistical_Refutations
1•aaavl2821•11m ago•0 comments

Dxc4.com – Chess analysis where the game lives in the URL

https://dxc4.com
1•kohlhofer•12m ago•1 comments

Vendor Locked

https://stitcher.io/blog/vendor-locked
1•moebrowne•12m ago•0 comments

Claude Sonnet 4 vs. 4.5: A Real-World Comparison

https://www.cosmicjs.com/blog/claude-sonnet-4-vs-45-a-real-world-comparison
1•tonyspiro•15m ago•0 comments

Metallica Share '72 Seasons' Lyric Videos in 9 Different Languages

https://loudwire.com/metallica-lyric-videos-different-languages-72-seasons/
1•nomilk•15m ago•1 comments

3.7M breach notification letters set to flood North America's mailboxes

https://www.theregister.com/2025/10/01/north_american_data_breaches/
4•mrguyorama•15m ago•0 comments

Trunk Flaky Test is out of beta

https://trunk.io/blog/trunk-flaky-tests-is-out-of-beta
1•samgutentag•16m ago•1 comments

Do you feel in control? Analysis of AWS CloudControl API as an attack tool

https://www.exaforce.com/blogs/feel-in-control-analysis-of-aws-cloudcontrol-api
1•ifoundanifty•19m ago•0 comments

Harvard Researchers Develop First Ever Continuously Operating Quantum Computer

https://www.thecrimson.com/article/2025/10/2/quantum-computing-breakthrough/
2•crazystar•20m ago•0 comments

Distracting software engineers is more harmful than most managers think

https://workweave.dev/blog/distracting-software-engineers-is-more-harmful-than-managers-think-eve...
4•AntonZ234•20m ago•0 comments

OpenAI Valuation Hits $500B

https://www.wsj.com/tech/ai/openai-valuation-hits-500-billion-while-altman-signs-more-deals-in-as...
2•bookofjoe•21m ago•1 comments

Anthropic announces "Built with Claude 4.5" challenge for developers

https://support.claude.com/en/articles/12450131-built-with-claude-contest-official-rules
2•gangtao•22m ago•2 comments

Trump's Drone Deal with Ukraine to Give U.S. Access to Battlefield Tech

https://www.wsj.com/world/europe/trumps-drone-deal-with-ukraine-to-give-u-s-access-to-battlefield...
5•JumpCrisscross•23m ago•1 comments

F Prime – A flight software and embedded systems framework

https://fprime.jpl.nasa.gov/
1•marklit•25m ago•0 comments
Open in hackernews

Does Big Pharma gouge Americans?

https://www.economist.com/business/2025/10/02/does-big-pharma-gouge-americans
19•cupola2030•1h ago

Comments

blindriver•47m ago
My friend’s daughter needs an eczema crème and was told the price was $1000 per tube and wasn’t covered under insurance.

The price in Canada is around $100. Yes, Big Pharma gouges Americans.

alephnerd•46m ago
That's your insurance provider that told you no - not "Big Pharma".

Which is what TFA points out as well:

"The bulk of the rents is captured instead by providers of health-care services such as hospitals and the system’s true money-makers: insurers, pharmacy-benefit managers and other middlemen taking advantage of its opacity. They have higher costs of capital than drugmakers, but they also clear our 10% hurdle much more comfortably (chart 3)"

tptacek•45m ago
Both are counterparties to negotiations that set price and availability, so it probably doesn't make sense to separate their role.
Analemma_•35m ago
Everyone is guilty here, because once one sector forms a monopoly, they have monopoly pricing power, and so their counterparty sectors have to form a monopoly as well to keep leverage in negotiations.

50 years ago, there were many more pharma companies, many more insurance companies, and many more hospitals under individual ownership. First the pharma companies consolidated, which give them monopoly pricing power over insurers. So then the insurance companies consolidated to they could negotiate on equal footing, but then they had monopoly pricing power over the hospitals. So then hospitals consolidated so they could negotiate. And now after decades of this, we're right back we're started, except for consumers, who can't consolidate and hence get fucked.

The two solutions here are either breaking up all the monopolies at the same time-- pharma, insurance, and hospitals-- so that everyone has market competition again, or letting health care consumers consolidate so they have pricing leverage-- i.e., forming a single-payer health-care system where the government negotiates deals on behalf of a 330+-million payer pool.

It does not make sense to either blame or spare one single sector: the pharmas, insurers and hospitals are all guilty, though in a sense all of their hands were forced by their counterparties. It's a coordination problem of exactly the kind government is supposed to solve, hence why government-run health care eventually seems like the only option.

SJC_Hacker•19m ago
> So then hospitals consolidated so they could negotiate. And now after decades of this, we're right back we're started, except for consumers, who can't consolidate and hence get fucked.

Consumer consolidation is called voting. Its too bad most consumers have voted in politicians who don't represent their best interests

thmsths•15m ago
I feel like you explained how we got there and our options to fix it perfectly. As you point out we have monopolies (or close to) at every single step. Whatever bandaid people and politician can come up with will quickly be neutralized by these conglomerates, at this point, any half measure is basically useless or has severe tradeoffs.
deadbabe•35m ago
So it should cost $550 in America and $550 in Canada.
tptacek•33m ago
It depends on your moral system. Equalizing costs across markets almost certainly reduces the number of people who can be served by a medication.
cpfohl•28m ago
I'd be really interested to see these costs averaged (like parent post) but then re-distributed by average income...
testing22321•28m ago
How do you know what their profit margins are in each country?

How much profit is enough?

megaman821•13m ago
Since most non-biological medicines don't cost very much to manufacture at all; enough profit is enough to cover that drug's R&D and the R&D of the 9 other drugs that didn't pan out. If the US market can cover all those costs, then whatever you get out of other countries is gravy. If that ceases to be true, then other countries will have to pony up more money or go without.
bradfa•15m ago
Population of the USA is about 340 million, population of Canada is about 42 million. Assuming similar statistics of people needing a given medicine, proper cost sharing to result in the same profits would put it much closer to the USA cost than the Canada cost.
newyankee•26m ago
Issue is more like 'the cure for high prices is high prices' does not seem to work in healthcare
BeepInABox•47m ago
Yes. /thread
tptacek•46m ago
https://archive.is/FFvWh
CapmCrackaWaka•43m ago
My wife and I recently decided to do IVF. The doctor specifically told us that we needed to order the medicine (menopur, Gonal F, etc) from an American pharmacy. That alone made me suspicious, so I looked at foreign options. Altogether, the medication required would have cost us about $5000 from American pharmacies. We found out that we can just buy the exact same stuff from a German pharmacy for about $1000. So yes, Americans get wrecked by drug prices.
deadbabe•39m ago
I think it’s even worse than this, perhaps America is subsidizing the rest of the world’s cheap medicines with its high prices. It makes sense to me. Extract everything you can from the American whales then throw out cheaper prices to the rest of the world long tail.

If America prohibited such gouging, would the rest of the world accept price increases on their drugs? If the current administration is so interested in inflicting harm on the rest of the world, maybe they should be convinced to lower drug prices.

badosu•31m ago
Seems like an interesting hypothesis to explore.

You didn't provide any context of why you think that could be the case or the mechanism through the alleged subsidies happen.

9question1•30m ago
The problem with this argument is that pharmaceutical companies are private businesses trying to make a profit, not charities. If it were truly unprofitable to sell drugs in, say, Canada or France, pharmaceutical companies would just not sell their drugs in those countries. It is _less_ profitable to sell drugs in those countries than America but still profitable, which is why they still try to capture those markets. If America fixed this imbalance by forcing a lowering of drug prices in the American market, there's no reason to believe that this would cause raising of prices elsewhere. The only way this would be possible is if it were truly unprofitable to sell the drugs elsewhere, which can't be the case since these are corporations not charities. The real impact would be to slow down new drug development, since existing drugs are already profitable to sell everywhere in the world even in countries with more regulation, but if America fixed its market by lowering drug prices for Americans, the total profitability of pharmaceuticals would decrease, decreasing the incentive to create new pharmaceuticals. That's a totally different and very plausible impact. Rising drug prices for existing drugs in other countries is not a plausible impact.
smallnix•19m ago
I think they are not saying it's unprofitable, but rather that the current government should shape the market so the environment levels more over US vs the rest. (of course please in a laissez-faire change the market style not the bad socialist stuff)
JumpCrisscross•19m ago
> If it were truly unprofitable to sell drugs in, say, Canada or France, pharmaceutical companies would just not sell their drugs in those countries

You’re confusing capital and operating costs. Once you’ve developed the drug, selling everywhere you can makes sense. When considering whether to develop a drug or invest in something else, America’s biotech market absolutely turns keys. (But not as uniquely as we think. Europe has a thriving R&D market, it’s just directly subsidised.)

mothballed•29m ago
You think pharma companies won't bill the rest of countries whatever the market can bear? I can't think of why they possibly would lower their prices even if the American government stops subsidizing their businesses via using their monopoly on violence to enforce our perverted IP regimes.
CharlesW•23m ago
For anyone reading not familiar with this, "America's drug prices are high because we're subsidizing the rest of the world" is MAGA propaganda, and is not based on logic. https://www.msn.com/en-us/news/politics/pfizer-agrees-to-dea...
carlosjobim•18m ago
What's the problem with talking points? Talking is the purpose of an open forum like this one. Let's argue against the points and not against the commenters.
CharlesW•9m ago
Fair point, I’ve corrected "talking point" to "propaganda" above. Not only does it not make any logical sense, but there is zero evidence that Big Pharma isn't pricing drugs to maximize profitability in every market in which they operate. Drug companies aren’t charities.
tedggh•8m ago
Europe is highly regulated. Other countries with nationalist governments if pushed too far will make their own generic versions. So no, increasing prices in other countries to offset the loses in the American market is not that simple.
Der_Einzige•26m ago
The sad reality is that if Americans stopped paying inflated prices the 40% of drugs discovered here would shrink to about 10% and world wide drug discovery would be massively reduced.

You literally have to get fucked or the world get fucked harder and drags you down with them. Same reason why NATO and the farm bill are good for America.

The greatest trick from the wealthy is to not just exploit you to get it, but to destroy any possibility of resistance to them. Even trying to resist does nothing but harms the under class even more than if you simply accept it.

“If you want a picture of the future, imagine a boot stamping on a human face—forever.“ - George Orwell, a communist/socialist

Edit: To the guy who claimed Orwell wasn't a communist, the POUM who he fought for in the Spanish Civil war was communist (https://en.wikipedia.org/wiki/POUM) and according to the soviet union was specifically trotskyist. If you fight for them you are a communist, even if and especially if you claim you weren't later in life.

tptacek•12m ago
Orwell was not a communist.
JumpCrisscross•16m ago
> doctor specifically told us that we needed to order the medicine (menopur, Gonal F, etc) from an American pharmacy

Why do they care? Referral bonus?

Did you report them?

tptacek•39m ago
The headline is terrible given the thesis of the short article.

The Economist's analysis creates a model that shows Pharma companies making "excess profits" (greater than 10% return on capital) second only to technology companies. In that sense, by the Economist's terms, they are in fact gouging.

But that's not really the point the Economist wants to make; rather, regardless of whatever profits Pharma is raking in, they're in fact a small component of overall health care spending. You could zero out Pharma profits (this is my point and not theirs) and not materially change US health spending.

In all these discussions about American health care, my first take is that everybody should go download the CMS National Health Expenditures, and make a beeline for "Expenditures by Type of Expenditure and Program" (it's just an Excel spreadsheet). It's an extremely intuitive breakdown of where all US health care spending goes, and who's paying for it, all on one sheet.

There are a lot of narratives about health care spending that do not survive first contact with that spreadsheet.

kspacewalk2•33m ago
Are you specifically referring to `Table 19 National Health Expenditures by Type of Expenditure and Program.xlsx` in the ZIP archive which can be downloaded at https://www.cms.gov/files/zip/nhe-tables.zip ?
tptacek•32m ago
Yeah the one I have hotlinked in Google Sheets is a "Table 19" but I didn't want to presume it's Table 19 every year.
dboreham•21m ago
Drug costs are contentious because they're easily visible and often no covered by insurance. The other costs are obfuscated in complex billing and hidden under principle/agent veils.

E.g. my son has a peanut allergy and so we need to buy EpiPens. They were hundreds of dollars, and the vendor played MBA-nonsense games like requiring two to be purchased at a time. Meanwhile I was able to drive to Canada and buy the exact same thing (and as many or as few as I needed) for tens of dollars.

tptacek•16m ago
We know where all the health spending in the system ends up, and while Pharma pricing is quite high and those companies are quite profitable, most of our health spending doesn't go to either Pharma or insurers.
megaman821•7m ago
That is annoying, but not a huge cost driver. If you son ended up in the ER it would cost multiple lifetimes of epipens (even at an inflated price).
abeppu•8m ago
I don't think the spending story alone is helpful because it doesn't acknowledge where there's room for actual improvement. Of the $1.5T spent on "Hospital Care", if almost all of it went to medical staff, facilities, equipment etc, and if good data suggested that people aren't in hospital unnecessarily, maybe that number isn't a problem. But if private hospitals have very fat margins, and some significant share of patients could be served just as well through less expensive clinical services, maybe that's too much.

In the context of the cost of medication, the $449B on "prescription drugs" doesn't break out what goes to drug makers vs PBMs or anyone else. We can easily imagine a world without PBMs that still delivers drugs to patients, but someone has to actually make the drugs. We can also ask, are people on medications they don't actually need? Are we sometimes _causing_ later health issues when medicating (e.g. fueling a giant opioid crisis)? None of this is apparent in the top-line spending figures.

diego_moita•38m ago
I'm surprised on the comments here that go: "I had to pay $$$$ for a medication when I could buy that same medication somewhere else for a fraction of it. Therefore Big Pharma gouges America".

That is not evidence that "Big Pharma gouges America". It is evidence that Americans pay a lot more than other countries. Only that. The conclusion doesn't necessarily follow from the premises.

Want to understand why? Read the article's last paragraph:

> The bulk of the rents is captured instead by providers of health-care services such as hospitals and the system’s true money-makers: insurers, pharmacy-benefit managers and other middlemen taking advantage of its opacity.

As always, no one reads anything.

tptacek•37m ago
Insurers make even less money than Pharma companies do. To a first approximation essentially all health care spending goes to companies that deliver health services directly.
diego_moita•28m ago
> Insurers make even less money than Pharma companies do.

In the whole or in relative terms? Source, even if personal or anecdotal?

I am willing to consider your point because, to be fair, the article doesn't show any data that indicts the insurers. They just blame them at the end without any evidence.

> all health care spending goes to companies that deliver health services directly.

Well, that wouldn't explain why medication alone is more expensive in America, right?

But accepting your argument: is it because of greed and oligopolies, incompetence or excess of regulation?

tptacek•27m ago
Hah, I wouldn't need "personal" or "anecdotal" evidence for this; it's right there in black and white in the NHE data; literally in the first row of the sheet. I posted about this across the thread.
mothballed•26m ago
No, he's right. Insurance profits are legally capped, and this keeps them from representing an outsized fraction of spending even in cases when they might partially be the driver behind it. They have to spend N% of their income on actual health care benefits. They're not absurdly high, you could look them up, but I don't think it's possible to exceed something like 10% profit.

This means the only way for insurance companies to increase profits is to increase the price of healthcare, and they have zero incentive to try and lower the amount of money they pay out for healthcare which might otherwise have been split between profits and lower premiums.

tptacek•18m ago
My guess is that if you found NHE data from before the ACA cap insurance would remain a small component of overall health spending (the ACA was very important and I am in no way downplaying it).

Mostly I'm saying: you don't have to axiomatically derive why this is. Medicare collects and synthesizes this data.

mothballed•13m ago
How would you derive it from medicare? Isn't medicare supposed to be non-profit? They should occupy 0% of health care spending once you remove the pass-through transfer payments that go back into medical care, minus some administration overhead.
tptacek•10m ago
The CMS collects these statistics in the same way that the BLS collects labor statistics. It has nothing specifically to do with the part of CMS that directly administers Medicare. The point is that we have very high quality data on this stuff.
delfinom•27m ago
Yea in fact the ACA law caps insurers to a maximum of 15% profit. Anything extra must be rebated back to the customers.

The debatable part is the rebate is back to the employer who is allowed to simply pocket the money, though one could argue its returning the amount the employer is covering, often more than the employee. :shrug:

Believe or not, I get yearly notices from UHC about rebates for the prior year.

tptacek•17m ago
Whatever the reasons are, I don't need first principles to make this claim, because Medicare presents this particular data quite clearly.
gertlex•30m ago
>> The bulk of the rents is captured instead by providers of health-care services such as hospitals and the system’s true money-makers: insurers, pharmacy-benefit managers and other middlemen taking advantage of its opacity.

> As always, no one reads anything.

The implication of the article was the "bulk of the rents" applies to healthcare costs in total, not just to drug costs. I.e. drug costs are not a huge part of the healthcare costs.

That by itself doesn't guarantee an understanding of why specific medication costs are sometimes 10x or whatever of other 1st world countries.

(but I didn't read the article; just the rest of the comments)

gruez•38m ago
For people who only read the title, note that the article is actually about a slightly different point:

>America is a lucrative market for the world’s drug giants. Many pharma bosses admit that is where they make most of their profits. But are these profits really responsible for America’s ballooning health-care bill? The short answer is no.

I don't think the article is disputing that Americans pay more for drugs than other countries, only that the pharma industry isn't the top gouger (or even above average) in the healthcare industry.

tiahura•27m ago
https://www.ama-assn.org/sites/ama-assn.org/files/2025-04/20...
bearjaws•32m ago
I work for a large mail order pharmacy and I will tell you we make no money on over 90% of our prescriptions. Our margin is less than 4%. The space is hyper competitive and obviously consumers are price sensitive. We are incredibly lean - less than 50 staff to run the pharmacy and a fully robotic dispensing line doing the vast majority of the dispensing.

The drug manufacturers are making massive profits, and nobody is stopping them.

Hilariously the whole TrumpRx card is kind of a step in the right direction, I've screamed for years that manufacturers blatantly rip everyone off and if just use a made up discount card system all of a sudden the drug is 30-90% off.

Ideally the government just says the global price is the US price, and eliminates discount cards entirely.

tptacek•30m ago
You only get access to the government-negotiated discount, which is from the pharma company list price, if you buy without insurance. But your insurance company already negotiated a discount from that list price (they're not dumb, and any excess dollar they give to Pfizer is a dollar they don't get to deploy elsewhere). From what little we know of the government discount, it is likely in most cases to be a worse price than what you already have access to.
Der_Einzige•30m ago
Just gonna leave this here…

https://en.m.wikipedia.org/wiki/Betteridge's_law_of_headline...

abeppu•30m ago
> The bulk of the rents is captured instead by providers of health-care services such as hospitals and the system’s true money-makers: insurers, pharmacy-benefit managers and other middlemen taking advantage of its opacity.

This category of "providers of health-care services" is rather over-broad, and I wish they had split it up more. Shouldn't hospitals (which actually _provide health care_ and are necessary parts of the healthcare system) be in a separate bucket from the "middlemen"?

And within the hospital category, don't we need to draw some distinctions? Currently in the US there's been press about how recent funding changes are causing a bunch of rural hospitals to shut down. It seems that some hospitals are major money losers, though we as a society may want them to continue to exist (or else a rural person in a medical emergency has no chance of getting care in time). But what's happening at the hospitals that _are_ collecting "rents", esp since in more urban contexts there are often multiple hospitals and one might expect more competition?

tboyd47•29m ago
The answer: Well, that depends on how you define "Big Pharma."
tiahura•28m ago
Where does healthcare spending go?

https://www.ama-assn.org/sites/ama-assn.org/files/2025-04/20...

nineplay•20m ago
I'm intrigued by the premise - I have my own large burden of health care costs and my own suspicions about where it is going - but does anyone else find their charts unreadable? I'm trying to parse the first one and I keep trying to put the pieces together. "Health care services" is 60 out of 101bn ... excess profits?

The second one I can hardly start on, "health care services" is a medium circle ( circle size = combined market capitalization ) with the second highest "Aggregate return on invested capital" and in the middle of "median weighted-average cost of capital".

I know its called "the economist" but they usually make their articles readable by people without a econ degree. If I had a suspicious mind ( I do ) I'd think this was deliberate obfuscation.

Also "health care services ... such as hospitals and the system’s true money-makers: insurers, pharmacy-benefit managers and other middlemen taking advantage of its opacity"

That is a lot of different interests bundled together. How can they say insurers are the true money makers when they are not even broken out?

xnx•17m ago
Seems like net income margin for an average US company is about ~10% and for big pharm it's ~14%. Regulations are probably what keeps pharma unusually profitable.
ktosobcy•15m ago
Americans created "big-pharma", "big-medical" and "big-insurance" for themselves and now they are living the consequences...